Matches in SemOpenAlex for { <https://semopenalex.org/work/W2784328305> ?p ?o ?g. }
- W2784328305 abstract "Elevated body mass index (BMI) is associated with increased risk of postmenopausal breast cancer. The underlying mechanisms, however, remain elusive.In a nested case-control study of 621 postmenopausal breast cancer case participants and 621 matched control participants, we measured 617 metabolites in prediagnostic serum. We calculated partial Pearson correlations between metabolites and BMI, and then evaluated BMI-associated metabolites (Bonferroni-corrected α level for 617 statistical tests = P < 8.10 × 10-5) in relation to invasive breast cancer. Odds ratios (ORs) of breast cancer comparing the 90th vs 10th percentile (modeled on a continuous basis) were estimated using conditional logistic regression while controlling for breast cancer risk factors, including BMI. Metabolites with the lowest P values (false discovery rate < 0.2) were mutually adjusted for one another to determine those independently associated with breast cancer risk.Of 67 BMI-associated metabolites, two were independently associated with invasive breast cancer risk: 16a-hydroxy-DHEA-3-sulfate (OR = 1.65, 95% confidence interval [CI] = 1.22 to 2.22) and 3-methylglutarylcarnitine (OR = 1.67, 95% CI = 1.21 to 2.30). Four metabolites were independently associated with estrogen receptor-positive (ER+) breast cancer risk: 16a-hydroxy-DHEA-3-sulfate (OR = 1.84, 95% CI = 1.27 to 2.67), 3-methylglutarylcarnitine (OR = 1.91, 95% CI = 1.23 to 2.96), allo-isoleucine (OR = 1.76, 95% CI = 1.23 to 2.51), and 2-methylbutyrylcarnitine (OR = 1.89, 95% CI = 1.22 to 2.91). In a model without metabolites, each 5 kg/m2 increase in BMI was associated with a 14% higher risk of breast cancer (OR = 1.14, 95% CI = 1.01 to 1.28), but adding 16a-hydroxy-DHEA-3-sulfate and 3-methylglutarylcarnitine weakened this association (OR = 1.06, 95% CI = 0.93 to 1.20), with the logOR attenuating by 57.6% (95% CI = 21.8% to 100.0+%).These four metabolites may signal metabolic pathways that contribute to breast carcinogenesis and that underlie the association of BMI with increased postmenopausal breast cancer risk. These findings warrant further replication efforts." @default.
- W2784328305 created "2018-01-26" @default.
- W2784328305 creator A5005351223 @default.
- W2784328305 creator A5009460223 @default.
- W2784328305 creator A5050104828 @default.
- W2784328305 creator A5050414089 @default.
- W2784328305 creator A5053374075 @default.
- W2784328305 creator A5054480104 @default.
- W2784328305 creator A5091281907 @default.
- W2784328305 date "2018-01-09" @default.
- W2784328305 modified "2023-10-04" @default.
- W2784328305 title "A Metabolomics Analysis of Body Mass Index and Postmenopausal Breast Cancer Risk" @default.
- W2784328305 cites W1219814361 @default.
- W2784328305 cites W1511930757 @default.
- W2784328305 cites W1540384934 @default.
- W2784328305 cites W1544070048 @default.
- W2784328305 cites W1551632868 @default.
- W2784328305 cites W1685808974 @default.
- W2784328305 cites W1813161579 @default.
- W2784328305 cites W1973198827 @default.
- W2784328305 cites W1975347641 @default.
- W2784328305 cites W1978281808 @default.
- W2784328305 cites W1988501594 @default.
- W2784328305 cites W1997747839 @default.
- W2784328305 cites W2007435247 @default.
- W2784328305 cites W2010768303 @default.
- W2784328305 cites W2017771330 @default.
- W2784328305 cites W2022537708 @default.
- W2784328305 cites W2026122583 @default.
- W2784328305 cites W2028996544 @default.
- W2784328305 cites W2032920995 @default.
- W2784328305 cites W2040147755 @default.
- W2784328305 cites W2041761779 @default.
- W2784328305 cites W2051693299 @default.
- W2784328305 cites W2052408325 @default.
- W2784328305 cites W2061071496 @default.
- W2784328305 cites W2067152194 @default.
- W2784328305 cites W2068256216 @default.
- W2784328305 cites W2069376956 @default.
- W2784328305 cites W2074073688 @default.
- W2784328305 cites W2074983857 @default.
- W2784328305 cites W2082917494 @default.
- W2784328305 cites W2083964309 @default.
- W2784328305 cites W2097259163 @default.
- W2784328305 cites W2104132854 @default.
- W2784328305 cites W2104309625 @default.
- W2784328305 cites W2105216337 @default.
- W2784328305 cites W2117692326 @default.
- W2784328305 cites W2119237938 @default.
- W2784328305 cites W2122367003 @default.
- W2784328305 cites W2123002438 @default.
- W2784328305 cites W2129392795 @default.
- W2784328305 cites W2132577252 @default.
- W2784328305 cites W2132617827 @default.
- W2784328305 cites W2138044466 @default.
- W2784328305 cites W2139566281 @default.
- W2784328305 cites W2149843865 @default.
- W2784328305 cites W2158958532 @default.
- W2784328305 cites W2165729145 @default.
- W2784328305 cites W2171427533 @default.
- W2784328305 cites W2202864399 @default.
- W2784328305 cites W2234203700 @default.
- W2784328305 cites W2252854900 @default.
- W2784328305 cites W2264167156 @default.
- W2784328305 cites W2288332502 @default.
- W2784328305 cites W2294143173 @default.
- W2784328305 cites W2341244791 @default.
- W2784328305 cites W2395626624 @default.
- W2784328305 cites W2404217920 @default.
- W2784328305 cites W2465888413 @default.
- W2784328305 cites W2476039382 @default.
- W2784328305 cites W2510411424 @default.
- W2784328305 cites W2513280988 @default.
- W2784328305 cites W2562984926 @default.
- W2784328305 cites W2568247792 @default.
- W2784328305 cites W2615073964 @default.
- W2784328305 cites W2616834435 @default.
- W2784328305 cites W2725832014 @default.
- W2784328305 cites W227779385 @default.
- W2784328305 doi "https://doi.org/10.1093/jnci/djx244" @default.
- W2784328305 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6279273" @default.
- W2784328305 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29325144" @default.
- W2784328305 hasPublicationYear "2018" @default.
- W2784328305 type Work @default.
- W2784328305 sameAs 2784328305 @default.
- W2784328305 citedByCount "45" @default.
- W2784328305 countsByYear W27843283052018 @default.
- W2784328305 countsByYear W27843283052019 @default.
- W2784328305 countsByYear W27843283052020 @default.
- W2784328305 countsByYear W27843283052021 @default.
- W2784328305 countsByYear W27843283052022 @default.
- W2784328305 countsByYear W27843283052023 @default.
- W2784328305 crossrefType "journal-article" @default.
- W2784328305 hasAuthorship W2784328305A5005351223 @default.
- W2784328305 hasAuthorship W2784328305A5009460223 @default.
- W2784328305 hasAuthorship W2784328305A5050104828 @default.
- W2784328305 hasAuthorship W2784328305A5050414089 @default.
- W2784328305 hasAuthorship W2784328305A5053374075 @default.
- W2784328305 hasAuthorship W2784328305A5054480104 @default.
- W2784328305 hasAuthorship W2784328305A5091281907 @default.