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- W2789435600 abstract "Specific regions of the cerebral cortex are highly plastic in an organism’s lifetime. It is thought that perineuronal nets (PNNs) regulate plasticity, but labeling for Wisteria floribunda agglutinin (WFA), which is widely used to detect PNNs, is observed throughout the cortex. The aggrecan molecule—a PNN component—may regulate plasticity, and may also be involved in determining region-specific vulnerability to stress. To clarify cortical region-specific plasticity and vulnerability, we qualitatively analyzed aggrecan-positive and glycosylated aggrecan-positive PNNs in the mature mouse cerebral cortex. Our findings revealed the selective expression of both aggrecan-positive and glycosylated aggrecan-positive PNNs in the cortex. WFA-positive PNNs expressed aggrecan in a region-specific manner in the cortex. Furthermore, we observed variable distributions of PNNs containing WFA- and aggrecan-positive molecules. Together, our findings suggest that PNN components and their function differ depending on the cortical region, and that aggrecan molecules may be involved in determining region-specific plasticity and vulnerability in the cortex." @default.
- W2789435600 created "2018-03-29" @default.
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- W2789435600 date "2018-06-01" @default.
- W2789435600 modified "2023-09-29" @default.
- W2789435600 title "Expression of aggrecan components in perineuronal nets in the mouse cerebral cortex" @default.
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- W2789435600 doi "https://doi.org/10.1016/j.ibror.2018.01.002" @default.
- W2789435600 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6084874" @default.