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- W2790282984 abstract "Currently, the multifaceted role of the extracellular matrix (ECM) in tumourigenesis has been realized. One ECM macromolecule exhibiting potent oncosuppressive actions in tumourigenesis is decorin, the prototype of the small leucine-rich proteoglycan gene family. The actions of decorin include its ability to function as an endogenous pan-receptor tyrosine kinase inhibitor, a regulator of both autophagy and mitophagy, as well as a modulator of the immune system. In this review, we will discuss these topics in more detail. We also provide a summary of preclinical studies exploring the value of decorin-mediated oncosuppression, as a potential future adjuvant therapy for epithelial cancers. Linked Articles This article is part of a themed section on Translating the Matrix. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v176.1/issuetoc" @default.
- W2790282984 created "2018-03-29" @default.
- W2790282984 creator A5038119547 @default.
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- W2790282984 date "2018-04-02" @default.
- W2790282984 modified "2023-10-06" @default.
- W2790282984 title "Decorin-mediated oncosuppression - a potential future adjuvant therapy for human epithelial cancers" @default.
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- W2790282984 doi "https://doi.org/10.1111/bph.14180" @default.
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