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- W2790708367 endingPage "487" @default.
- W2790708367 startingPage "449" @default.
- W2790708367 abstract "Transmucosal drug delivery routes offer an attractive alternative to injectable drugs because of their ease of administration and increased patient compliance. Many strategies have been developed to overcome the inherent barriers to drug delivery across mucosal routes. Among these, nanocarrier-mediated mucosal delivery has received great attention over the last years. Rationally designed nanocarriers could protect the associated drugs and establish contact with the mucosal tissue for efficient delivery. Within this context, the interaction of nanoparticles with the mucus layer that protects the underlying epithelium is a complex process, and the understanding of this interaction is a critical factor for the rational design of efficient nanocarriers. In addition, the fact that the different administration routes such as oral, nasal, ocular, or pulmonary have their own set of favorable and unfavorable properties, which should also be considered for successful transmucosal delivery. In this chapter, we summarize the specific anatomical features and biological barriers associated with different mucosal administration routes. We also provide an overview of the more relevant experimental techniques developed to understand the behavior of colloidal drug carriers on their contact with mucosal surfaces. Finally, we also present herein the current state of the art of mucosal delivery strategies, based on the rational design of functionalized nanocarriers." @default.
- W2790708367 created "2018-03-29" @default.
- W2790708367 creator A5007989476 @default.
- W2790708367 creator A5016230351 @default.
- W2790708367 creator A5052296555 @default.
- W2790708367 creator A5078855912 @default.
- W2790708367 date "2018-01-01" @default.
- W2790708367 modified "2023-10-17" @default.
- W2790708367 title "Functionalized Polymeric Nanostructures for Mucosal Drug Delivery" @default.
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