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• W2795573669 abstract "The genetic, molecular and neuronal mechanism underlying circadian activity rhythms is well characterized in the brain of Drosophila. The small ventrolateral neurons (s-LNVs) and pigment dispersing factor (PDF) expressed by them are especially important for regulating circadian locomotion. Here we describe a novel gene, Dstac, which is similar to the stac genes found in vertebrates that encode adaptor proteins, which bind and regulate L-type voltage-gated Ca2+ channels (CaChs). We show that Dstac is coexpressed with PDF by the s-LNVs and regulates circadian activity. Furthermore, the L-type CaCh, Dmca1D, appears to be expressed by the s-LNVs. Since vertebrate Stac3 regulates an L-type CaCh we hypothesize that Dstac regulates Dmca1D in s-LNVs and circadian activity." @default.
• W2795573669 created "2018-04-13" @default.
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• W2795573669 date "2018-04-05" @default.
• W2795573669 modified "2023-09-24" @default.
• W2795573669 title "<i>Dstac</i>is required for normal circadian activity rhythms in<i>Drosophila</i>" @default.
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• W2795573669 doi "https://doi.org/10.1080/07420528.2018.1454937" @default.
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