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• W2801470111 abstract "The woodchuck hepatitis virus (WHV) is closely related to human hepatitis Bvirus (HBV), the prototypic member of the Hepanaviridae family. Toll-like receptors(TLRs) may play an important role in the pathogenesis of hepadnaviral hepatitis,however, little is known about their expression during the course of hepadnaviralinfection. In this study, woodchuck TLRs1-10 gene exon fragments were identified andtheir transcriptional profiles investigated in livers, hepatocytes isolated from these livers,and peripheral blood mononuclear cells (PBMCs) from healthy woodchucks andanimals with different stages of experimental WHV infection. Overall expressionanalysis revealed that livers from woodchucks with acute hepatitis (AH) and chronichepatitis (CH) had significantly upregulated expression of TLRs2-10 when compared tothe livers of healthy animals and those with self-limited acute hepatitis (SLAH) andprimary occult infection (POI). This was likely due to intrahepatic immune cellinfiltration. In contrast, a significant downregulation of TLR3, TLR5, TLR7, TLR8, andTLR10 expression was identified in hepatocytes of woodchucks with CH whencompared to hepatocytes from healthy animals and those with pre-acute hepatitis(PreAH), SLAH and POI. This may suggest WHV active suppression of the innateimmune response in these cells. Upregulated transcription of the majority of TLRs wasfound in PBMCs during CH but not in other stages of infection. In summary, this studyuncovered that TLR expression is significantly modulated depending on the stage ofWHV infection and form of hepatitis. Treatments designed to restore hepatocyte TLRexpression may allow for better control of the virus through activation of a strongerintrahepatocyte immune response during CH." @default.
• W2801470111 created "2018-05-17" @default.
• W2801470111 creator A5015065243 @default.
• W2801470111 date "2017-05-01" @default.
• W2801470111 modified "2023-09-22" @default.
• W2801470111 title "Identification of woodchuck toll-like receptors and their expression during the course of hepadnaviral infection in the woodchuck model of hepatitis B" @default.
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