FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2802367710> ?p ?o ?g. }

• W2802367710 endingPage "919" @default.
• W2802367710 startingPage "904" @default.
• W2802367710 abstract "Genome-wide association studies (GWASs) have successfully identified thousands of genetic variants for many complex diseases; however, these variants explain only a small fraction of the heritability. Recently, genetic association studies that leverage external transcriptome data have received much attention and shown promise for discovering novel variants. One such approach, PrediXcan, is to use predicted gene expression through genetic regulation. However, there are limitations in this approach. The predicted gene expression may be biased, resulting from regularized regression applied to moderately sample-sized reference studies. Further, some variants can individually influence disease risk through alternative functional mechanisms besides expression. Thus, testing only the association of predicted gene expression as proposed in PrediXcan will potentially lose power. To tackle these challenges, we consider a unified mixed effects model that formulates the association of intermediate phenotypes such as imputed gene expression through fixed effects, while allowing residual effects of individual variants to be random. We consider a set-based score testing framework, MiST (mixed effects score test), and propose two data-driven combination approaches to jointly test for the fixed and random effects. We establish the asymptotic distributions, which enable rapid calculation of p values for genome-wide analyses, and provide p values for fixed and random effects separately to enhance interpretability over GWASs. Extensive simulations demonstrate that our approaches are more powerful than existing ones. We apply our approach to a large-scale GWAS of colorectal cancer and identify two genes, POU5F1B and ATF1, which would have otherwise been missed by PrediXcan, after adjusting for all known loci." @default.
• W2802367710 created "2018-05-17" @default.
• W2802367710 creator A5016377624 @default.
• W2802367710 creator A5020564648 @default.
• W2802367710 creator A5022350262 @default.
• W2802367710 creator A5023667273 @default.
• W2802367710 creator A5023746352 @default.
• W2802367710 creator A5025110284 @default.
• W2802367710 creator A5034883098 @default.
• W2802367710 creator A5035274153 @default.
• W2802367710 creator A5036777611 @default.
• W2802367710 creator A5037851771 @default.
• W2802367710 creator A5041567188 @default.
• W2802367710 creator A5042390536 @default.
• W2802367710 creator A5043636252 @default.
• W2802367710 creator A5044867785 @default.
• W2802367710 creator A5048280160 @default.
• W2802367710 creator A5048819576 @default.
• W2802367710 creator A5049975246 @default.
• W2802367710 creator A5053074659 @default.
• W2802367710 creator A5053681099 @default.
• W2802367710 creator A5066410308 @default.
• W2802367710 creator A5068274938 @default.
• W2802367710 creator A5073098968 @default.
• W2802367710 creator A5073774490 @default.
• W2802367710 creator A5075165389 @default.
• W2802367710 creator A5076040901 @default.
• W2802367710 creator A5077206620 @default.
• W2802367710 creator A5078559681 @default.
• W2802367710 creator A5079082650 @default.
• W2802367710 creator A5082578863 @default.
• W2802367710 creator A5083672487 @default.
• W2802367710 creator A5084496654 @default.
• W2802367710 creator A5086460310 @default.
• W2802367710 creator A5086740139 @default.
• W2802367710 creator A5090508414 @default.
• W2802367710 creator A5091653870 @default.
• W2802367710 date "2018-05-01" @default.
• W2802367710 modified "2023-10-17" @default.
• W2802367710 title "A Mixed-Effects Model for Powerful Association Tests in Integrative Functional Genomics" @default.
• W2802367710 cites W1533942137 @default.
• W2802367710 cites W1844405070 @default.
• W2802367710 cites W1959032726 @default.
• W2802367710 cites W1989568128 @default.
• W2802367710 cites W2000262021 @default.
• W2802367710 cites W2001528153 @default.
• W2802367710 cites W2010789111 @default.
• W2802367710 cites W2015845481 @default.
• W2802367710 cites W2019983262 @default.
• W2802367710 cites W2023155906 @default.
• W2802367710 cites W2026373901 @default.
• W2802367710 cites W2029387902 @default.
• W2802367710 cites W2054344444 @default.
• W2802367710 cites W2055705596 @default.
• W2802367710 cites W2058148991 @default.
• W2802367710 cites W2059744149 @default.
• W2802367710 cites W2076154138 @default.
• W2802367710 cites W2078059415 @default.
• W2802367710 cites W2100909778 @default.
• W2802367710 cites W2101505979 @default.
• W2802367710 cites W2105502933 @default.
• W2802367710 cites W2108797218 @default.
• W2802367710 cites W2113594760 @default.
• W2802367710 cites W2121323687 @default.
• W2802367710 cites W2122698311 @default.
• W2802367710 cites W2133107210 @default.
• W2802367710 cites W2138162444 @default.
• W2802367710 cites W2144961623 @default.
• W2802367710 cites W2147297736 @default.
• W2802367710 cites W2152505144 @default.
• W2802367710 cites W2156714600 @default.
• W2802367710 cites W2158272128 @default.
• W2802367710 cites W2160995259 @default.
• W2802367710 cites W2163953557 @default.
• W2802367710 cites W2198606573 @default.
• W2802367710 cites W2209106767 @default.
• W2802367710 cites W2259938310 @default.
• W2802367710 cites W2264585211 @default.
• W2802367710 cites W2315138803 @default.
• W2802367710 cites W2334877168 @default.
• W2802367710 cites W2519527699 @default.
• W2802367710 cites W2619347383 @default.
• W2802367710 cites W2765253743 @default.
• W2802367710 cites W2768587352 @default.
• W2802367710 cites W278413204 @default.
• W2802367710 cites W2809045255 @default.
• W2802367710 cites W2953051599 @default.
• W2802367710 cites W4213327946 @default.
• W2802367710 doi "https://doi.org/10.1016/j.ajhg.2018.03.019" @default.
• W2802367710 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5986723" @default.
• W2802367710 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29727690" @default.
• W2802367710 hasPublicationYear "2018" @default.
• W2802367710 type Work @default.
• W2802367710 sameAs 2802367710 @default.
• W2802367710 citedByCount "28" @default.
• W2802367710 countsByYear W28023677102018 @default.
• W2802367710 countsByYear W28023677102019 @default.
• W2802367710 countsByYear W28023677102020 @default.

• next