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- W2802641570 startingPage "164" @default.
- W2802641570 abstract "Alzheimer’s disease (AD) is a chronic neurodegenerative disease, which is considered as one of the most intractable medical problems with heavy social and economic costs. The current drugs for AD, including acetylcholinesterase inhibitors (AChEIs) and memantine, a NMDA receptor antagonist, only temporarily ameliorate cognitive decline, but are unable to stop or reverse the progression of dementia. This paper reviewed the recent advance in AD drug development. The drug discovery programs under clinical trials targeting cholinergic system, α7 nicotinic acetylcholine receptors (nAChRs), N-methyl-d-aspartate receptor (NMDAR), β-secretase, γ-secretase modulators, tau, inflammatory mediators and glucagon-like peptide-1 (GLP-1) were discussed. Though several drug discovery programs are ongoing, the high failure rate is an outstanding issue. Novel techniques and strategies are desperately needed to significantly accelerate this process." @default.
- W2802641570 created "2018-05-17" @default.
- W2802641570 creator A5007967304 @default.
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- W2802641570 creator A5077690878 @default.
- W2802641570 creator A5079969251 @default.
- W2802641570 date "2018-06-20" @default.
- W2802641570 modified "2023-10-06" @default.
- W2802641570 title "Drug development for Alzheimer’s disease: review" @default.
- W2802641570 cites W1447565288 @default.
- W2802641570 cites W1522284801 @default.
- W2802641570 cites W1566065415 @default.
- W2802641570 cites W1746708220 @default.
- W2802641570 cites W1825826250 @default.
- W2802641570 cites W1841850981 @default.
- W2802641570 cites W1934667138 @default.
- W2802641570 cites W1967359815 @default.
- W2802641570 cites W1973830433 @default.
- W2802641570 cites W197587746 @default.
- W2802641570 cites W1978281908 @default.
- W2802641570 cites W1991794361 @default.
- W2802641570 cites W1991993391 @default.
- W2802641570 cites W1995839193 @default.
- W2802641570 cites W1996715055 @default.
- W2802641570 cites W2000075190 @default.
- W2802641570 cites W2001436176 @default.
- W2802641570 cites W2001868890 @default.
- W2802641570 cites W2003159754 @default.
- W2802641570 cites W2004535959 @default.
- W2802641570 cites W2010046611 @default.
- W2802641570 cites W2013146608 @default.
- W2802641570 cites W2015484447 @default.
- W2802641570 cites W2016193774 @default.
- W2802641570 cites W2026970282 @default.
- W2802641570 cites W2027462994 @default.
- W2802641570 cites W2036755018 @default.
- W2802641570 cites W2047420624 @default.
- W2802641570 cites W2049451196 @default.
- W2802641570 cites W2055379425 @default.
- W2802641570 cites W2055659156 @default.
- W2802641570 cites W2056790763 @default.
- W2802641570 cites W2057679568 @default.
- W2802641570 cites W2058614488 @default.
- W2802641570 cites W2060851420 @default.
- W2802641570 cites W2062307561 @default.
- W2802641570 cites W2065469785 @default.
- W2802641570 cites W2066494697 @default.
- W2802641570 cites W2070837551 @default.
- W2802641570 cites W2073618542 @default.
- W2802641570 cites W2073977687 @default.
- W2802641570 cites W2083556882 @default.
- W2802641570 cites W2087451417 @default.
- W2802641570 cites W2089337215 @default.
- W2802641570 cites W2089765958 @default.
- W2802641570 cites W2090968981 @default.
- W2802641570 cites W2098035383 @default.
- W2802641570 cites W2113690827 @default.
- W2802641570 cites W2115776368 @default.
- W2802641570 cites W2116456562 @default.
- W2802641570 cites W2118559415 @default.
- W2802641570 cites W2118935254 @default.
- W2802641570 cites W2124536609 @default.
- W2802641570 cites W2124852816 @default.
- W2802641570 cites W2127370803 @default.
- W2802641570 cites W2128124856 @default.
- W2802641570 cites W2129085204 @default.
- W2802641570 cites W2130629200 @default.
- W2802641570 cites W2131479776 @default.
- W2802641570 cites W2135780456 @default.
- W2802641570 cites W2136623897 @default.
- W2802641570 cites W2138206059 @default.
- W2802641570 cites W2139481638 @default.
- W2802641570 cites W2154755614 @default.
- W2802641570 cites W2157064933 @default.
- W2802641570 cites W2158854213 @default.
- W2802641570 cites W2166070786 @default.
- W2802641570 cites W2166109990 @default.
- W2802641570 cites W2256482421 @default.
- W2802641570 cites W2258663952 @default.
- W2802641570 cites W2261777694 @default.
- W2802641570 cites W2289661106 @default.
- W2802641570 cites W2293608890 @default.
- W2802641570 cites W2302662614 @default.
- W2802641570 cites W2329336071 @default.
- W2802641570 cites W2331696045 @default.
- W2802641570 cites W2385703614 @default.
- W2802641570 cites W2467749231 @default.
- W2802641570 cites W2507955117 @default.
- W2802641570 cites W2517534055 @default.
- W2802641570 cites W2534984889 @default.
- W2802641570 cites W2548224030 @default.
- W2802641570 cites W2553725768 @default.
- W2802641570 cites W2553774099 @default.
- W2802641570 cites W2559946394 @default.
- W2802641570 cites W2565340265 @default.
- W2802641570 cites W2589440020 @default.