Matches in SemOpenAlex for { <https://semopenalex.org/work/W2803441129> ?p ?o ?g. }
- W2803441129 endingPage "6" @default.
- W2803441129 startingPage "1" @default.
- W2803441129 abstract "Numerous genetic alterations of HSA 11q13 are found frequently in several cancer types, including breast cancer (BC). The 11q13 locus harbors FADS2 encoding Δ6 desaturation which is not functional in several cancer cell lines, including hormone positive MCF7 BC cells. In vitro, the non-functional FADS2 activity unmasks 18:2n-6 elongation to 20:2n-6 and Δ5 desaturation by FADS1 to yield 5Z,11Z,14Z-20:3 (sciadonic acid) rather than 5Z,8Z,11Z,14Z-20:4 (arachidonic acid). In this pilot study we aimed to determine whether 5,11,14-20:3 appears in vivo in hormone positive human BC tissue. Fatty acids were profiled in surgically removed human breast tumor and adjacent normal tissue (n = 9). Sciadonic acid was detected in three of nine breast tumor samples and was below detect limits in normal breast tissue. The internal Δ8 double bond of arachidonic acid is required for normal eicosanoid synthesis but is missing in sciadonic acid. This pilot study demonstrates for the first time in vivo sciadonic acid in hormone positive BC tissue, warranting a larger survey study to further evaluate its appearance and the functional implications." @default.
- W2803441129 created "2018-06-01" @default.
- W2803441129 creator A5005044274 @default.
- W2803441129 creator A5005312959 @default.
- W2803441129 creator A5005372369 @default.
- W2803441129 creator A5010241495 @default.
- W2803441129 creator A5016963833 @default.
- W2803441129 creator A5019965559 @default.
- W2803441129 creator A5028758511 @default.
- W2803441129 creator A5034896031 @default.
- W2803441129 creator A5064539052 @default.
- W2803441129 creator A5070821158 @default.
- W2803441129 date "2018-07-01" @default.
- W2803441129 modified "2023-09-27" @default.
- W2803441129 title "A rare eicosanoid precursor analogue, sciadonic acid (5Z,11Z,14Z–20:3), detected in vivo in hormone positive breast cancer tissue" @default.
- W2803441129 cites W1437839308 @default.
- W2803441129 cites W1483795718 @default.
- W2803441129 cites W1520870796 @default.
- W2803441129 cites W1541830479 @default.
- W2803441129 cites W1573912538 @default.
- W2803441129 cites W1600294598 @default.
- W2803441129 cites W1605022478 @default.
- W2803441129 cites W1818048492 @default.
- W2803441129 cites W1975397632 @default.
- W2803441129 cites W1980861196 @default.
- W2803441129 cites W1982561172 @default.
- W2803441129 cites W1987556047 @default.
- W2803441129 cites W1988662722 @default.
- W2803441129 cites W1996856207 @default.
- W2803441129 cites W1997148726 @default.
- W2803441129 cites W2002668908 @default.
- W2803441129 cites W2005156019 @default.
- W2803441129 cites W2009368934 @default.
- W2803441129 cites W2009826571 @default.
- W2803441129 cites W2011298649 @default.
- W2803441129 cites W2013862513 @default.
- W2803441129 cites W2014001512 @default.
- W2803441129 cites W2014349355 @default.
- W2803441129 cites W2015224186 @default.
- W2803441129 cites W2020471584 @default.
- W2803441129 cites W2026251993 @default.
- W2803441129 cites W2026643194 @default.
- W2803441129 cites W2028691872 @default.
- W2803441129 cites W2039219561 @default.
- W2803441129 cites W2039844838 @default.
- W2803441129 cites W2051745134 @default.
- W2803441129 cites W2051819770 @default.
- W2803441129 cites W2057910997 @default.
- W2803441129 cites W2058616596 @default.
- W2803441129 cites W2062181868 @default.
- W2803441129 cites W2064635464 @default.
- W2803441129 cites W2069758725 @default.
- W2803441129 cites W2071744304 @default.
- W2803441129 cites W2072000048 @default.
- W2803441129 cites W2072105173 @default.
- W2803441129 cites W2073338663 @default.
- W2803441129 cites W2075356083 @default.
- W2803441129 cites W2075595785 @default.
- W2803441129 cites W2078847990 @default.
- W2803441129 cites W2081466642 @default.
- W2803441129 cites W2084322369 @default.
- W2803441129 cites W2088545470 @default.
- W2803441129 cites W2095242052 @default.
- W2803441129 cites W2097195427 @default.
- W2803441129 cites W2098522451 @default.
- W2803441129 cites W2112187558 @default.
- W2803441129 cites W2136499331 @default.
- W2803441129 cites W2317934215 @default.
- W2803441129 cites W2323078563 @default.
- W2803441129 cites W2339959472 @default.
- W2803441129 cites W2469416225 @default.
- W2803441129 cites W2500377063 @default.
- W2803441129 cites W2560322684 @default.
- W2803441129 cites W2570618306 @default.
- W2803441129 cites W2582623762 @default.
- W2803441129 cites W2593659162 @default.
- W2803441129 cites W2727357760 @default.
- W2803441129 cites W4302997885 @default.
- W2803441129 doi "https://doi.org/10.1016/j.plefa.2018.05.002" @default.
- W2803441129 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5999340" @default.
- W2803441129 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29886893" @default.
- W2803441129 hasPublicationYear "2018" @default.
- W2803441129 type Work @default.
- W2803441129 sameAs 2803441129 @default.
- W2803441129 citedByCount "7" @default.
- W2803441129 countsByYear W28034411292021 @default.
- W2803441129 countsByYear W28034411292022 @default.
- W2803441129 countsByYear W28034411292023 @default.
- W2803441129 crossrefType "journal-article" @default.
- W2803441129 hasAuthorship W2803441129A5005044274 @default.
- W2803441129 hasAuthorship W2803441129A5005312959 @default.
- W2803441129 hasAuthorship W2803441129A5005372369 @default.
- W2803441129 hasAuthorship W2803441129A5010241495 @default.
- W2803441129 hasAuthorship W2803441129A5016963833 @default.
- W2803441129 hasAuthorship W2803441129A5019965559 @default.
- W2803441129 hasAuthorship W2803441129A5028758511 @default.
- W2803441129 hasAuthorship W2803441129A5034896031 @default.
- W2803441129 hasAuthorship W2803441129A5064539052 @default.