Matches in SemOpenAlex for { <https://semopenalex.org/work/W2805945793> ?p ?o ?g. }
- W2805945793 abstract "Abstract Robustness is a key system-level property of living organisms to maintain their functions while tolerating perturbations. We investigate here how a regulatory network controlling multiple virulence factors impacts phenotypic robustness of a bacterial plant pathogen. We reconstruct a cell-scale model of Ralstonia solanacearum connecting a genome-scale metabolic network, a virulence macromolecule network, and a virulence regulatory network, which includes 63 regulatory components. We develop in silico methods to quantify phenotypic robustness under a broad set of conditions in high-throughput simulation analyses. This approach reveals that the virulence regulatory network exerts a control of the primary metabolism to promote robustness upon infection. The virulence regulatory network plugs into the primary metabolism mainly through the control of genes likely acquired via horizontal gene transfer, which results in a functional overlay with ancestral genes. These results support the view that robustness may be a selected trait that promotes pathogenic fitness upon infection." @default.
- W2805945793 created "2018-06-13" @default.
- W2805945793 creator A5001473736 @default.
- W2805945793 creator A5030447174 @default.
- W2805945793 creator A5043000344 @default.
- W2805945793 creator A5074791227 @default.
- W2805945793 date "2018-01-29" @default.
- W2805945793 modified "2023-10-10" @default.
- W2805945793 title "Control of primary metabolism by a virulence regulatory network promotes robustness in a plant pathogen" @default.
- W2805945793 cites W1534101457 @default.
- W2805945793 cites W1587983189 @default.
- W2805945793 cites W1800858326 @default.
- W2805945793 cites W1915578613 @default.
- W2805945793 cites W1964344318 @default.
- W2805945793 cites W1965638459 @default.
- W2805945793 cites W1970764623 @default.
- W2805945793 cites W1971866274 @default.
- W2805945793 cites W1972304384 @default.
- W2805945793 cites W1973941177 @default.
- W2805945793 cites W1976024539 @default.
- W2805945793 cites W1977027195 @default.
- W2805945793 cites W1980751665 @default.
- W2805945793 cites W1984654391 @default.
- W2805945793 cites W1985432682 @default.
- W2805945793 cites W2000993970 @default.
- W2805945793 cites W2002449525 @default.
- W2805945793 cites W2003003919 @default.
- W2805945793 cites W2012600591 @default.
- W2805945793 cites W2018108454 @default.
- W2805945793 cites W2022589976 @default.
- W2805945793 cites W2030813675 @default.
- W2805945793 cites W2031849942 @default.
- W2805945793 cites W2033613462 @default.
- W2805945793 cites W2046268781 @default.
- W2805945793 cites W2051116946 @default.
- W2805945793 cites W2055611983 @default.
- W2805945793 cites W2057718174 @default.
- W2805945793 cites W2067258168 @default.
- W2805945793 cites W2068588530 @default.
- W2805945793 cites W2069614478 @default.
- W2805945793 cites W2077175850 @default.
- W2805945793 cites W2078355959 @default.
- W2805945793 cites W2081981294 @default.
- W2805945793 cites W2103328552 @default.
- W2805945793 cites W2105028012 @default.
- W2805945793 cites W2111647009 @default.
- W2805945793 cites W2121672428 @default.
- W2805945793 cites W2125963417 @default.
- W2805945793 cites W2126175129 @default.
- W2805945793 cites W2126176298 @default.
- W2805945793 cites W2129325583 @default.
- W2805945793 cites W2135413308 @default.
- W2805945793 cites W2136225763 @default.
- W2805945793 cites W2139647452 @default.
- W2805945793 cites W2142792710 @default.
- W2805945793 cites W2145435867 @default.
- W2805945793 cites W2146856248 @default.
- W2805945793 cites W2147814423 @default.
- W2805945793 cites W2150360867 @default.
- W2805945793 cites W2151655468 @default.
- W2805945793 cites W2152578038 @default.
- W2805945793 cites W2160378127 @default.
- W2805945793 cites W2160541874 @default.
- W2805945793 cites W2161602811 @default.
- W2805945793 cites W2168244801 @default.
- W2805945793 cites W2169641851 @default.
- W2805945793 cites W2169826788 @default.
- W2805945793 cites W2171580484 @default.
- W2805945793 cites W2210051933 @default.
- W2805945793 cites W2216418212 @default.
- W2805945793 cites W2291919195 @default.
- W2805945793 cites W2531281183 @default.
- W2805945793 cites W2553667667 @default.
- W2805945793 cites W2557290566 @default.
- W2805945793 cites W2594824548 @default.
- W2805945793 cites W2600333931 @default.
- W2805945793 cites W2604975207 @default.
- W2805945793 cites W2614867515 @default.
- W2805945793 cites W4211017114 @default.
- W2805945793 doi "https://doi.org/10.1038/s41467-017-02660-4" @default.
- W2805945793 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5788922" @default.
- W2805945793 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29379078" @default.
- W2805945793 hasPublicationYear "2018" @default.
- W2805945793 type Work @default.
- W2805945793 sameAs 2805945793 @default.
- W2805945793 citedByCount "27" @default.
- W2805945793 countsByYear W28059457932018 @default.
- W2805945793 countsByYear W28059457932019 @default.
- W2805945793 countsByYear W28059457932020 @default.
- W2805945793 countsByYear W28059457932021 @default.
- W2805945793 countsByYear W28059457932022 @default.
- W2805945793 countsByYear W28059457932023 @default.
- W2805945793 crossrefType "journal-article" @default.
- W2805945793 hasAuthorship W2805945793A5001473736 @default.
- W2805945793 hasAuthorship W2805945793A5030447174 @default.
- W2805945793 hasAuthorship W2805945793A5043000344 @default.
- W2805945793 hasAuthorship W2805945793A5074791227 @default.
- W2805945793 hasBestOaLocation W28059457931 @default.
- W2805945793 hasConcept C101810790 @default.
- W2805945793 hasConcept C104317684 @default.