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- W2808049474 abstract "Start domain-containing protein 3 (Stard3) plays roles in intracellular cholesterol distribution, however, the role of Stard3 in the adipogenesis of 3T3-L1 preadipocytes remains unclear. We demonstrated that Stard3 expression was significantly increased during the adipogenesis of 3T3-L1 preadipocytes, accompanied by an increase of mitochondrial Reactive oxygen species (ROS). Stard3 knocking-down inhibited 3T3-L1 preadipocyte adipogenesis with decreased mitochondrial ROS levels, while ROS inducer rescued the stard3 silencing 3T3 cells with increased ROS. Moreover, Stard3 silencing reduced the expression of peroxisome proliferator-activated receptor-γ (PPARγ) and CCAAT/enhancer binding protein (C/EBP)α in 3T3- L1 cells. In conclusion, Stard3 enhanced the adipogenesis of preadipocytes by enhancement of cholesterol redistribution to the mitochondrial, increasing mitochondrial ROS production. These results suggest that Stard3 is an essential factor for the 3T3-L1 cells' differentiation." @default.
- W2808049474 created "2018-06-21" @default.
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- W2808049474 date "2018-10-01" @default.
- W2808049474 modified "2023-10-15" @default.
- W2808049474 title "Knocking down Stard3 decreases adipogenesis with decreased mitochondrial ROS in 3T3-L1 cells" @default.
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- W2808049474 doi "https://doi.org/10.1016/j.bbrc.2018.06.030" @default.
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