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- W2808889454 abstract "Essential oils show important biological activities, which account for the development of aromatherapy used in complementary and alternative medicine. The aim of this study was to evaluate the chemical composition and the antioxidant, anti-melanogenic, and anti-inflammatory properties of Glechoma hederacea essential oil (GH-EO). The essential oil composition was analyzed by gas chromatography and mass spectrometry. The most abundant compound in GH-EO was trans-3-pinanone (41.4%), and other major compounds were 4,5,6,7-Tetrahydro-5-isopropenyl-3,6-beta-dimethyl-6-alpha-vinylbenzofuran (10.8%), β-caryophyllene (10.2%), and spathulenol (4.3%). Our results indicated that GH-EO shows strong lipid peroxidation inhibitory activity for the moderation of β-carotene bleaching. GH-EO can markedly decrease melanin production and tyrosinase activity in α-melanin-stimulating-hormone (α-MSH)-stimulated B16 cells. The results also demonstrated that the activity of GH-EO on melanogenesis might be the result of its potent antioxidative ability (P < 0.05), which was reflected in the decreased cellular oxidant and malondialdehyde (MDA) levels and in the recovered activities of glutathione peroxidase (GPX) and superoxide dismutase (SOD) in α-MSH stimulated B16 cells. GH-EO may suppress the inflammatory responses of LPS-stimulated RAW 264.7 macrophages, including nitric oxide (NO) production, by regulating the expression of the inflammation-related enzymes inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), and heme oxygenase-1 (HO-1), and the inflammatory cytokine tumor necrosis factor-α (TNF-α), which decreases LPS-induced MDA levels and DNA damage." @default.
- W2808889454 created "2018-06-29" @default.
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- W2808889454 date "2018-10-01" @default.
- W2808889454 modified "2023-09-25" @default.
- W2808889454 title "Chemical composition, antioxidant, anti-melanogenic and anti-inflammatory activities of Glechoma hederacea (Lamiaceae) essential oil" @default.
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- W2808889454 doi "https://doi.org/10.1016/j.indcrop.2018.06.032" @default.
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