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• W281322245 abstract "Abstract Background Genome‐wide association studies ( GWAS ) have identified single nucleotide polymorphisms ( SNPs ) associated with type 2 diabetes ( T2D ), mainly among individuals of E uropean ancestry. In the present study, we examined the frequency of these SNPs and their association with T2D ‐related traits in an A laska N ative study population with a historically low prevalence of T2D . We also investigated whether dietary characteristics that may protect against T2D , such as n‐3 polyunsaturated fatty acid ( PUFA ) intake, modify these associations. Methods In 1144 Y up'ik people, we examined 17 SNPs repeatedly identified in GWAS for individual and cumulative associations with T2D ‐related traits. Cumulative associations were evaluated using a genetic risk score ( GRS ) calculated by summing risk alleles. Associations were tested for interactions with sex, body mass index ( BMI ), and n‐3 PUFA intake. Results The rs7754840 SNP in CDKAL1 is significantly associated with HbA1c ( P = 0.00091). The rs5015480 SNP near HHEX is significantly associated (in opposite direction to that in Europeans) with a combined fasting glucose ( FG ) and HbA1c measure ( P = 0.00046) and with homeostatic model assessment of β‐cell function ( HOMA ‐ B ; P = 0.0014). The GRS is significantly associated with FG and combined FG and HbA1c only when the HHEX SNP is dropped from the GRS . Associations are not modified by BMI or n‐3 PUFA intake. Conclusion Our results highlight the potential importance of CDKAL1 and HHEX in glucose homeostasis in this A laska N ative population with a low prevalence of T2D , and suggest that these loci should be examined in greater detail in this population." @default.
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• W281322245 date "2013-10-29" @default.
• W281322245 modified "2023-10-17" @default.
• W281322245 title "<i>CDKAL1</i>and<i>HHEX</i>are associated with type 2 diabetes-related traits among Yup'ik people (在尤皮克人群中<i>CDKAL1</i>和<i>HHEX</i>与2型糖尿病相关特征有关)" @default.
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• W281322245 doi "https://doi.org/10.1111/1753-0407.12093" @default.
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