FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2820797251> ?p ?o ?g. }

• W2820797251 endingPage "31" @default.
• W2820797251 startingPage "25" @default.
• W2820797251 abstract "Background and purpose In recent decades, outcomes of patients with head and neck cancer (HNC) have improved as a result of implementing several strategies, such as chemoradiation. However, these improvements were achieved at the cost of increased toxicity. One way to reduce radiation-related toxicity is by reducing the margins. Materials and methods Between 2013 and 2016, 206 consecutive patients were treated with CTV-PTV margin of 5 mm and subsequently 208 patients with 3 mm margin. This study evaluates the impact of reducing clinical target volume (CTV) to planning target volume (PTV) margin on outcome and toxicity. Results All patients were treated with volumetric modulated arc therapy (VMAT) with daily-image guidance using cone-beam CT (CBCT). Overall acute grade 3 toxicity was significantly lower in 3 mm-group, compared to 5 mm-group (53.8% vs. 65%, respectively, p = 0.032). The same was true for acute grade 3 mucositis (30.8% vs. 42.2%, p = 0.008) and for acute grade 3 dysphagia (feeding tube-dependence) (22.1% vs. 33.5%, p = 0.026). The incidence of ongoing feeding tube-dependence after 3 months of radiotherapy was 11.1% and 20.4%, respectively (p = 0.012). The 2-year incidence of late grade ≥2 xerostomia was 15.8% and 19.4% (p = 0.8). The 2-year loco-regional control rates of patients treated in 3 mm and 5 mm-groups were 79.9% and 79.2% (p = 1.0). The figures for disease-free survival were 71.5% and 72.7 (p = 0.6) and for overall survival were 75.2% and 75.1% (p = 0.9). Conclusion Reducing the CTV-PTV margin from 5 to 3 mm combined with daily CBCT-guided VMAT reduced the severity, frequency, and duration of radiation-related toxicity without jeopardizing outcome." @default.
• W2820797251 created "2018-07-19" @default.
• W2820797251 creator A5012310620 @default.
• W2820797251 creator A5019743332 @default.
• W2820797251 creator A5022999007 @default.
• W2820797251 creator A5027012956 @default.
• W2820797251 creator A5041177696 @default.
• W2820797251 creator A5044517920 @default.
• W2820797251 creator A5048369598 @default.
• W2820797251 creator A5063155328 @default.
• W2820797251 creator A5080806192 @default.
• W2820797251 creator A5087851185 @default.
• W2820797251 date "2019-01-01" @default.
• W2820797251 modified "2023-10-18" @default.
• W2820797251 title "The impact of margin reduction on outcome and toxicity in head and neck cancer patients treated with image-guided volumetric modulated arc therapy (VMAT)" @default.
• W2820797251 cites W1504613168 @default.
• W2820797251 cites W1975544605 @default.
• W2820797251 cites W1989207107 @default.
• W2820797251 cites W2020066330 @default.
• W2820797251 cites W2030671730 @default.
• W2820797251 cites W2067910869 @default.
• W2820797251 cites W2076797886 @default.
• W2820797251 cites W2081365004 @default.
• W2820797251 cites W2085813356 @default.
• W2820797251 cites W2088021312 @default.
• W2820797251 cites W2089257078 @default.
• W2820797251 cites W2089664967 @default.
• W2820797251 cites W2091753311 @default.
• W2820797251 cites W2099156085 @default.
• W2820797251 cites W2107919790 @default.
• W2820797251 cites W2140110477 @default.
• W2820797251 cites W2148754315 @default.
• W2820797251 cites W2159533511 @default.
• W2820797251 cites W2163750179 @default.
• W2820797251 cites W2166005406 @default.
• W2820797251 cites W2169496348 @default.
• W2820797251 cites W2523243607 @default.
• W2820797251 cites W2645116524 @default.
• W2820797251 cites W2734485989 @default.
• W2820797251 cites W2772467824 @default.
• W2820797251 cites W2793139049 @default.
• W2820797251 doi "https://doi.org/10.1016/j.radonc.2018.06.032" @default.
• W2820797251 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30005953" @default.
• W2820797251 hasPublicationYear "2019" @default.
• W2820797251 type Work @default.
• W2820797251 sameAs 2820797251 @default.
• W2820797251 citedByCount "55" @default.
• W2820797251 countsByYear W28207972512019 @default.
• W2820797251 countsByYear W28207972512020 @default.
• W2820797251 countsByYear W28207972512021 @default.
• W2820797251 countsByYear W28207972512022 @default.
• W2820797251 countsByYear W28207972512023 @default.
• W2820797251 crossrefType "journal-article" @default.
• W2820797251 hasAuthorship W2820797251A5012310620 @default.
• W2820797251 hasAuthorship W2820797251A5019743332 @default.
• W2820797251 hasAuthorship W2820797251A5022999007 @default.
• W2820797251 hasAuthorship W2820797251A5027012956 @default.
• W2820797251 hasAuthorship W2820797251A5041177696 @default.
• W2820797251 hasAuthorship W2820797251A5044517920 @default.
• W2820797251 hasAuthorship W2820797251A5048369598 @default.
• W2820797251 hasAuthorship W2820797251A5063155328 @default.
• W2820797251 hasAuthorship W2820797251A5080806192 @default.
• W2820797251 hasAuthorship W2820797251A5087851185 @default.
• W2820797251 hasConcept C116263406 @default.
• W2820797251 hasConcept C120665830 @default.
• W2820797251 hasConcept C121332964 @default.
• W2820797251 hasConcept C126322002 @default.
• W2820797251 hasConcept C141071460 @default.
• W2820797251 hasConcept C2776530083 @default.
• W2820797251 hasConcept C2778045676 @default.
• W2820797251 hasConcept C2778496288 @default.
• W2820797251 hasConcept C2780596822 @default.
• W2820797251 hasConcept C29730261 @default.
• W2820797251 hasConcept C2989005 @default.
• W2820797251 hasConcept C3018411727 @default.
• W2820797251 hasConcept C509974204 @default.
• W2820797251 hasConcept C61511704 @default.
• W2820797251 hasConcept C71924100 @default.
• W2820797251 hasConceptScore W2820797251C116263406 @default.
• W2820797251 hasConceptScore W2820797251C120665830 @default.
• W2820797251 hasConceptScore W2820797251C121332964 @default.
• W2820797251 hasConceptScore W2820797251C126322002 @default.
• W2820797251 hasConceptScore W2820797251C141071460 @default.
• W2820797251 hasConceptScore W2820797251C2776530083 @default.
• W2820797251 hasConceptScore W2820797251C2778045676 @default.
• W2820797251 hasConceptScore W2820797251C2778496288 @default.
• W2820797251 hasConceptScore W2820797251C2780596822 @default.
• W2820797251 hasConceptScore W2820797251C29730261 @default.
• W2820797251 hasConceptScore W2820797251C2989005 @default.
• W2820797251 hasConceptScore W2820797251C3018411727 @default.
• W2820797251 hasConceptScore W2820797251C509974204 @default.
• W2820797251 hasConceptScore W2820797251C61511704 @default.
• W2820797251 hasConceptScore W2820797251C71924100 @default.
• W2820797251 hasLocation W28207972511 @default.
• W2820797251 hasLocation W28207972512 @default.
• W2820797251 hasOpenAccess W2820797251 @default.
• W2820797251 hasPrimaryLocation W28207972511 @default.
• W2820797251 hasRelatedWork W1974239774 @default.

• next