Matches in SemOpenAlex for { <https://semopenalex.org/work/W2883990417> ?p ?o ?g. }
- W2883990417 endingPage "550" @default.
- W2883990417 startingPage "541" @default.
- W2883990417 abstract "This study investigated the angiotensin I-converting enzyme (ACE)-inhibitory activity and antihypertensive effect of alcalase-, flavourzyme-, and protease N-digested porcine brain hydrolysates (PBHs) on spontaneously hypertensive rats (SHRs) after their oral administration. In addition, we investigated whether a peptide fraction with a molecular weight of less than 3 000 Da inhibits ACE in vitro and lowers arterial blood pressure. The results revealed that PBHs obtained after 4 h of hydrolysis with protease N (PBP4H) yielded peptides enriched with ACE-inhibitory activity (86.29 ± 5.76%). Furthermore, PBP4H had the lowest ACE-inhibitory activity IC50 value (1.945 mg/mL). Oral administration of PBP4H-100 (100 mg/kg bw/day) and low-molecular-weight peptide fractions, PBP4H < 3 000 Da (50 mg/kg bw/d) reduced the systolic blood pressure (−30 mmHg) in SHRs. Moreover, the long-term administration of PBP4H-100 and PBP4H < 3 000 Da significantly suppressed hypertension. In addition, results of the plasma ACE activity was positively related with the SBP lowering effects of PBP4Hs. Overall, these results reveal the antihypertensive effect of PBH and as a functional supplement for suppressing hypertension." @default.
- W2883990417 created "2018-08-03" @default.
- W2883990417 creator A5012706476 @default.
- W2883990417 creator A5018730787 @default.
- W2883990417 creator A5029670240 @default.
- W2883990417 creator A5042619326 @default.
- W2883990417 creator A5050820291 @default.
- W2883990417 creator A5057591079 @default.
- W2883990417 creator A5086871164 @default.
- W2883990417 date "2018-01-01" @default.
- W2883990417 modified "2023-10-06" @default.
- W2883990417 title "Production, Analysis and <i>in Vivo</i> Antihypertensive Evaluation of Novel Angiotensin-I-converting Enzyme Inhibitory Peptides from Porcine Brain" @default.
- W2883990417 cites W17038625 @default.
- W2883990417 cites W1975630793 @default.
- W2883990417 cites W1976179916 @default.
- W2883990417 cites W1978389916 @default.
- W2883990417 cites W1987000855 @default.
- W2883990417 cites W1992530337 @default.
- W2883990417 cites W2001408043 @default.
- W2883990417 cites W2010510947 @default.
- W2883990417 cites W2014482403 @default.
- W2883990417 cites W2017560704 @default.
- W2883990417 cites W2021840805 @default.
- W2883990417 cites W2028238448 @default.
- W2883990417 cites W2034569261 @default.
- W2883990417 cites W2050138289 @default.
- W2883990417 cites W2053286287 @default.
- W2883990417 cites W2054530987 @default.
- W2883990417 cites W2057474364 @default.
- W2883990417 cites W2070776705 @default.
- W2883990417 cites W2075342193 @default.
- W2883990417 cites W2075819111 @default.
- W2883990417 cites W2075882202 @default.
- W2883990417 cites W2076932143 @default.
- W2883990417 cites W2079924190 @default.
- W2883990417 cites W2080456946 @default.
- W2883990417 cites W2105278239 @default.
- W2883990417 cites W2111729861 @default.
- W2883990417 cites W2115896899 @default.
- W2883990417 cites W2149098516 @default.
- W2883990417 cites W2154176941 @default.
- W2883990417 cites W2155196578 @default.
- W2883990417 cites W2156121263 @default.
- W2883990417 cites W2156203505 @default.
- W2883990417 cites W2221487527 @default.
- W2883990417 cites W2282588792 @default.
- W2883990417 doi "https://doi.org/10.3136/fstr.24.541" @default.
- W2883990417 hasPublicationYear "2018" @default.
- W2883990417 type Work @default.
- W2883990417 sameAs 2883990417 @default.
- W2883990417 citedByCount "1" @default.
- W2883990417 countsByYear W28839904172019 @default.
- W2883990417 crossrefType "journal-article" @default.
- W2883990417 hasAuthorship W2883990417A5012706476 @default.
- W2883990417 hasAuthorship W2883990417A5018730787 @default.
- W2883990417 hasAuthorship W2883990417A5029670240 @default.
- W2883990417 hasAuthorship W2883990417A5042619326 @default.
- W2883990417 hasAuthorship W2883990417A5050820291 @default.
- W2883990417 hasAuthorship W2883990417A5057591079 @default.
- W2883990417 hasAuthorship W2883990417A5086871164 @default.
- W2883990417 hasBestOaLocation W28839904171 @default.
- W2883990417 hasConcept C126322002 @default.
- W2883990417 hasConcept C134018914 @default.
- W2883990417 hasConcept C150903083 @default.
- W2883990417 hasConcept C181199279 @default.
- W2883990417 hasConcept C185592680 @default.
- W2883990417 hasConcept C198710026 @default.
- W2883990417 hasConcept C202751555 @default.
- W2883990417 hasConcept C207001950 @default.
- W2883990417 hasConcept C27016395 @default.
- W2883990417 hasConcept C2776714187 @default.
- W2883990417 hasConcept C2777056448 @default.
- W2883990417 hasConcept C2777752497 @default.
- W2883990417 hasConcept C2779281246 @default.
- W2883990417 hasConcept C2779611605 @default.
- W2883990417 hasConcept C28800991 @default.
- W2883990417 hasConcept C2908929049 @default.
- W2883990417 hasConcept C55493867 @default.
- W2883990417 hasConcept C71924100 @default.
- W2883990417 hasConcept C84393581 @default.
- W2883990417 hasConcept C86803240 @default.
- W2883990417 hasConcept C94412978 @default.
- W2883990417 hasConcept C98274493 @default.
- W2883990417 hasConceptScore W2883990417C126322002 @default.
- W2883990417 hasConceptScore W2883990417C134018914 @default.
- W2883990417 hasConceptScore W2883990417C150903083 @default.
- W2883990417 hasConceptScore W2883990417C181199279 @default.
- W2883990417 hasConceptScore W2883990417C185592680 @default.
- W2883990417 hasConceptScore W2883990417C198710026 @default.
- W2883990417 hasConceptScore W2883990417C202751555 @default.
- W2883990417 hasConceptScore W2883990417C207001950 @default.
- W2883990417 hasConceptScore W2883990417C27016395 @default.
- W2883990417 hasConceptScore W2883990417C2776714187 @default.
- W2883990417 hasConceptScore W2883990417C2777056448 @default.
- W2883990417 hasConceptScore W2883990417C2777752497 @default.
- W2883990417 hasConceptScore W2883990417C2779281246 @default.
- W2883990417 hasConceptScore W2883990417C2779611605 @default.
- W2883990417 hasConceptScore W2883990417C28800991 @default.