Matches in SemOpenAlex for { <https://semopenalex.org/work/W2887804511> ?p ?o ?g. }
- W2887804511 endingPage "317" @default.
- W2887804511 startingPage "305" @default.
- W2887804511 abstract "Despite the distinct advantages of poly(dimethylsiloxane) (PDMS) for biomedical applications, because of its hydrophobic nature, suffers from non-specific protein adsorption and platelet adhesion and activation when used as a blood-contacting material. To confer hydrophilicity and biomolecules repelling characteristics, well-defined and high-density poly(2-hydroxyethyl methacrylate) (PHEMA) brushes are synthesized via surface-initiated atom transfer radical polymerization (SI-ATRP) on the PDMS substrate. First, PDMS surface is activated using an ultraviolet/ozone (UVO) wet treatment in water media to introduce hydroxy moieties without scarifying the surface property resulting a crack-free SiO2 surface. Then, 3-(2-bromoisobutyramido)propyl(trimethoxy)silane (BrTMOS), the active ATRP initiator, is immobilized on the UVO-treated PDMS surface to prepare a thin layer of hydrophilic PHEMA brush on PDMS substrate exhibiting excellent protein and platelet resistance. PHEMA brushes supply a biomimetic feature by combining antifouling properties due to hydrophilic characteristic with bioactive properties resulted from the presence of a high density hydroxy groups, which are subsequently used for biomolecules conjugation. The results indicate that grafting of PHEMA chains on the PDMS surface enhances the surface wettability which leads to a decrease in non-specific protein adsorption and platelet adhesion compared to the bare PDMS substrate. The adhered platelets on the PHEMA-tethered PDMS substrate maintain their normal round morphology. Furthermore, the conjugated gelatin macromolecules onto the tethered PHEMA chains promote the adherence and growth of human umbilical vein endothelial cells via ligand-receptor interactions." @default.
- W2887804511 created "2018-08-22" @default.
- W2887804511 creator A5009750459 @default.
- W2887804511 creator A5028281603 @default.
- W2887804511 creator A5034559870 @default.
- W2887804511 creator A5043145928 @default.
- W2887804511 creator A5049683203 @default.
- W2887804511 creator A5058850416 @default.
- W2887804511 creator A5081484085 @default.
- W2887804511 date "2018-09-01" @default.
- W2887804511 modified "2023-09-30" @default.
- W2887804511 title "Biomimetic antifouling PDMS surface developed via well-defined polymer brushes for cardiovascular applications" @default.
- W2887804511 cites W138570360 @default.
- W2887804511 cites W1502534177 @default.
- W2887804511 cites W1563055217 @default.
- W2887804511 cites W1965194151 @default.
- W2887804511 cites W1966081825 @default.
- W2887804511 cites W1968129543 @default.
- W2887804511 cites W1968965037 @default.
- W2887804511 cites W1972278871 @default.
- W2887804511 cites W1973791641 @default.
- W2887804511 cites W1974352390 @default.
- W2887804511 cites W1974994744 @default.
- W2887804511 cites W1975985075 @default.
- W2887804511 cites W1978883932 @default.
- W2887804511 cites W1981791383 @default.
- W2887804511 cites W1982058920 @default.
- W2887804511 cites W1984633334 @default.
- W2887804511 cites W1985061395 @default.
- W2887804511 cites W1985227719 @default.
- W2887804511 cites W1985710997 @default.
- W2887804511 cites W1986263537 @default.
- W2887804511 cites W1991225846 @default.
- W2887804511 cites W1992396382 @default.
- W2887804511 cites W1994299103 @default.
- W2887804511 cites W1994695426 @default.
- W2887804511 cites W1995063875 @default.
- W2887804511 cites W1995927245 @default.
- W2887804511 cites W1997515846 @default.
- W2887804511 cites W2002654355 @default.
- W2887804511 cites W2005593738 @default.
- W2887804511 cites W2008651265 @default.
- W2887804511 cites W2009586206 @default.
- W2887804511 cites W2018244375 @default.
- W2887804511 cites W2019366993 @default.
- W2887804511 cites W2019668643 @default.
- W2887804511 cites W2021623392 @default.
- W2887804511 cites W2023418428 @default.
- W2887804511 cites W2023562421 @default.
- W2887804511 cites W2023734568 @default.
- W2887804511 cites W2024344043 @default.
- W2887804511 cites W2024397939 @default.
- W2887804511 cites W2025042378 @default.
- W2887804511 cites W2025226232 @default.
- W2887804511 cites W2026896696 @default.
- W2887804511 cites W2028339715 @default.
- W2887804511 cites W2031379133 @default.
- W2887804511 cites W2031732057 @default.
- W2887804511 cites W2034559321 @default.
- W2887804511 cites W2034724454 @default.
- W2887804511 cites W2037825918 @default.
- W2887804511 cites W2041218941 @default.
- W2887804511 cites W2045055557 @default.
- W2887804511 cites W2046425506 @default.
- W2887804511 cites W2047597192 @default.
- W2887804511 cites W2048526255 @default.
- W2887804511 cites W2051903431 @default.
- W2887804511 cites W2053699445 @default.
- W2887804511 cites W2057347415 @default.
- W2887804511 cites W2062642057 @default.
- W2887804511 cites W2063942934 @default.
- W2887804511 cites W2067018811 @default.
- W2887804511 cites W2068565992 @default.
- W2887804511 cites W2080881601 @default.
- W2887804511 cites W2084711027 @default.
- W2887804511 cites W2084888647 @default.
- W2887804511 cites W2085816307 @default.
- W2887804511 cites W2087177903 @default.
- W2887804511 cites W2089511414 @default.
- W2887804511 cites W2089624427 @default.
- W2887804511 cites W2093173771 @default.
- W2887804511 cites W2100530157 @default.
- W2887804511 cites W2101876314 @default.
- W2887804511 cites W2115304881 @default.
- W2887804511 cites W2119961090 @default.
- W2887804511 cites W2120257336 @default.
- W2887804511 cites W2121440289 @default.
- W2887804511 cites W2128392700 @default.
- W2887804511 cites W2130093942 @default.
- W2887804511 cites W2131414785 @default.
- W2887804511 cites W2135350520 @default.
- W2887804511 cites W2138431756 @default.
- W2887804511 cites W2139974724 @default.
- W2887804511 cites W2154452493 @default.
- W2887804511 cites W2314155051 @default.
- W2887804511 cites W2317581951 @default.
- W2887804511 cites W2317700521 @default.
- W2887804511 cites W2319276481 @default.