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- W2887903669 abstract "Microtubule stabilizing agents are among the most clinically useful chemotherapeutic drugs. Mostly, they act to stabilize microtubules and inhibit cell division. While not without side effects, new generations of these compounds display improved pharmacokinetic properties and brain penetrance. Neurological disorders are intrinsically associated with microtubule defects, and efforts to reposition microtubule-targeting chemotherapeutic agents for treatment of neurodegenerative and psychiatric illnesses are underway. Here we catalogue microtubule regulators that are associated with Alzheimer’s and Parkinson’s disease, amyotrophic lateral sclerosis, schizophrenia and mood disorders. We outline the classes of microtubule stabilizing agents used for cancer treatment, their brain penetrance properties and neuropathy side effects, and describe efforts to apply these agents for treatment of brain disorders. Finally, we summarize the current state of clinical trials for microtubule stabilizing agents under evaluation for central nervous system disorders." @default.
- W2887903669 created "2018-08-22" @default.
- W2887903669 creator A5041454607 @default.
- W2887903669 creator A5063451537 @default.
- W2887903669 creator A5073811582 @default.
- W2887903669 date "2018-08-08" @default.
- W2887903669 modified "2023-10-04" @default.
- W2887903669 title "Repositioning Microtubule Stabilizing Drugs for Brain Disorders" @default.
- W2887903669 cites W128425973 @default.
- W2887903669 cites W141471325 @default.
- W2887903669 cites W1496314348 @default.
- W2887903669 cites W1526197602 @default.
- W2887903669 cites W1584899905 @default.
- W2887903669 cites W1944052538 @default.
- W2887903669 cites W1964959041 @default.
- W2887903669 cites W1965782412 @default.
- W2887903669 cites W1965785026 @default.
- W2887903669 cites W1969129718 @default.
- W2887903669 cites W1969529487 @default.
- W2887903669 cites W1971353582 @default.
- W2887903669 cites W1971423558 @default.
- W2887903669 cites W1975586358 @default.
- W2887903669 cites W1977100803 @default.
- W2887903669 cites W1978698505 @default.
- W2887903669 cites W1978799642 @default.
- W2887903669 cites W1979302187 @default.
- W2887903669 cites W1984573641 @default.
- W2887903669 cites W1984939118 @default.
- W2887903669 cites W1994345832 @default.
- W2887903669 cites W1995783411 @default.
- W2887903669 cites W1996316175 @default.
- W2887903669 cites W1998420327 @default.
- W2887903669 cites W2001077544 @default.
- W2887903669 cites W2005402647 @default.
- W2887903669 cites W2009843455 @default.
- W2887903669 cites W2011142100 @default.
- W2887903669 cites W2013627836 @default.
- W2887903669 cites W2013908628 @default.
- W2887903669 cites W2015377426 @default.
- W2887903669 cites W2016231557 @default.
- W2887903669 cites W2017856054 @default.
- W2887903669 cites W2021404217 @default.
- W2887903669 cites W2022435711 @default.
- W2887903669 cites W2024314776 @default.
- W2887903669 cites W2030430356 @default.
- W2887903669 cites W2030641075 @default.
- W2887903669 cites W2032212474 @default.
- W2887903669 cites W2032396306 @default.
- W2887903669 cites W2032588521 @default.
- W2887903669 cites W2035752371 @default.
- W2887903669 cites W2036878135 @default.
- W2887903669 cites W2037490361 @default.
- W2887903669 cites W2037804097 @default.
- W2887903669 cites W2039291773 @default.
- W2887903669 cites W2044695226 @default.
- W2887903669 cites W2045063195 @default.
- W2887903669 cites W2045100800 @default.
- W2887903669 cites W2046917278 @default.
- W2887903669 cites W2048839541 @default.
- W2887903669 cites W2049570656 @default.
- W2887903669 cites W2049971831 @default.
- W2887903669 cites W2050084837 @default.
- W2887903669 cites W2050490738 @default.
- W2887903669 cites W2056991512 @default.
- W2887903669 cites W2057249855 @default.
- W2887903669 cites W2060071458 @default.
- W2887903669 cites W2060602451 @default.
- W2887903669 cites W2064199931 @default.
- W2887903669 cites W2066694751 @default.
- W2887903669 cites W2070116427 @default.
- W2887903669 cites W2072986748 @default.
- W2887903669 cites W2073374817 @default.
- W2887903669 cites W2078775260 @default.
- W2887903669 cites W2079820299 @default.
- W2887903669 cites W2081406767 @default.
- W2887903669 cites W2081938650 @default.
- W2887903669 cites W2083119026 @default.
- W2887903669 cites W2083217982 @default.
- W2887903669 cites W2083306074 @default.
- W2887903669 cites W2084247881 @default.
- W2887903669 cites W2084328300 @default.
- W2887903669 cites W2084963741 @default.
- W2887903669 cites W2087386228 @default.
- W2887903669 cites W2088110780 @default.
- W2887903669 cites W2089136119 @default.
- W2887903669 cites W2089428712 @default.
- W2887903669 cites W2089893897 @default.
- W2887903669 cites W2091265794 @default.
- W2887903669 cites W2091970266 @default.
- W2887903669 cites W2091982343 @default.
- W2887903669 cites W2095165627 @default.
- W2887903669 cites W2096526911 @default.
- W2887903669 cites W2097496333 @default.
- W2887903669 cites W2103741076 @default.
- W2887903669 cites W2104326963 @default.
- W2887903669 cites W2107607807 @default.
- W2887903669 cites W2108485077 @default.
- W2887903669 cites W2110079555 @default.
- W2887903669 cites W2111371725 @default.
- W2887903669 cites W2112001901 @default.