FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2890529589> ?p ?o ?g. }

• W2890529589 endingPage "117693431879735" @default.
• W2890529589 startingPage "117693431879735" @default.
• W2890529589 abstract "With the daily release of data from whole genome sequencing projects, tools to facilitate comparative studies are hard-pressed to keep pace. Graphical software solutions can readily recognize synteny by measuring similarities between sequences. Nevertheless, regions of dissimilarity can prove to be equally informative; these regions may harbor genes acquired via lateral gene transfer (LGT), signify gene loss or gain, or include coding regions under strong selection. Previously, we developed the software S-plot. This tool employed an alignment-free approach for comparing bacterial genomes and generated a heatmap representing the genomes' similarities and dissimilarities in nucleotide usage. In prior studies, this tool proved valuable in identifying genome rearrangements as well as exogenous sequences acquired via LGT in several bacterial species. Herein, we present the next generation of this tool, S-plot2. Similar to its predecessor, S-plot2 creates an interactive, 2-dimensional heatmap capturing the similarities and dissimilarities in nucleotide usage between genomic sequences (partial or complete). This new version, however, includes additional metrics for analysis, new reporting options, and integrated BLAST query functionality for the user to interrogate regions of interest. Furthermore, S-plot2 can evaluate larger sequences, including whole eukaryotic chromosomes. To illustrate some of the applications of the tool, 2 case studies are presented. The first examines strain-specific variation across the Pseudomonas aeruginosa genome and strain-specific LGT events. In the second case study, corresponding human, chimpanzee, and rhesus macaque autosomes were studied and lineage specific contributions to divergence were estimated. S-plot2 provides a means to both visually and quantitatively compare nucleotide sequences, from microbial genomes to eukaryotic chromosomes. The case studies presented illustrate just 2 potential applications of the tool, highlighting its capability to identify and investigate the variation in molecular divergence rates across sequences. S-plot2 is freely available through https://bitbucket.org/lkalesinskas/splot and is supported on the Linux and MS Windows operating systems." @default.
• W2890529589 created "2018-09-27" @default.
• W2890529589 creator A5027121994 @default.
• W2890529589 creator A5033333203 @default.
• W2890529589 creator A5073753324 @default.
• W2890529589 creator A5082302003 @default.
• W2890529589 date "2018-01-01" @default.
• W2890529589 modified "2023-10-16" @default.
• W2890529589 title "S-plot2: Rapid Visual and Statistical Analysis of Genomic Sequences" @default.
• W2890529589 cites W1689369637 @default.
• W2890529589 cites W1849979647 @default.
• W2890529589 cites W1967843471 @default.
• W2890529589 cites W1970517964 @default.
• W2890529589 cites W1991330646 @default.
• W2890529589 cites W2000191164 @default.
• W2890529589 cites W2004391041 @default.
• W2890529589 cites W2040745248 @default.
• W2890529589 cites W2041257508 @default.
• W2890529589 cites W2041737819 @default.
• W2890529589 cites W2055043387 @default.
• W2890529589 cites W2062043949 @default.
• W2890529589 cites W2075319493 @default.
• W2890529589 cites W2076124986 @default.
• W2890529589 cites W2092857772 @default.
• W2890529589 cites W2100225159 @default.
• W2890529589 cites W2103225674 @default.
• W2890529589 cites W2103241734 @default.
• W2890529589 cites W2111097957 @default.
• W2890529589 cites W2112780227 @default.
• W2890529589 cites W2119158206 @default.
• W2890529589 cites W2136583046 @default.
• W2890529589 cites W2140560927 @default.
• W2890529589 cites W2143420371 @default.
• W2890529589 cites W2143699138 @default.
• W2890529589 cites W2151750549 @default.
• W2890529589 cites W2156273926 @default.
• W2890529589 cites W2158423461 @default.
• W2890529589 cites W215943697 @default.
• W2890529589 cites W2159757193 @default.
• W2890529589 cites W2164217177 @default.
• W2890529589 cites W2165891191 @default.
• W2890529589 cites W2167470356 @default.
• W2890529589 cites W2171963266 @default.
• W2890529589 cites W2175743436 @default.
• W2890529589 cites W2178845774 @default.
• W2890529589 cites W2233881958 @default.
• W2890529589 cites W2235699210 @default.
• W2890529589 cites W2253095351 @default.
• W2890529589 cites W2290216457 @default.
• W2890529589 cites W2315521535 @default.
• W2890529589 cites W2340497515 @default.
• W2890529589 cites W2432572080 @default.
• W2890529589 cites W2546819275 @default.
• W2890529589 cites W2951002538 @default.
• W2890529589 cites W4210539126 @default.
• W2890529589 doi "https://doi.org/10.1177/1176934318797354" @default.
• W2890529589 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6144591" @default.
• W2890529589 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30245567" @default.
• W2890529589 hasPublicationYear "2018" @default.
• W2890529589 type Work @default.
• W2890529589 sameAs 2890529589 @default.
• W2890529589 citedByCount "7" @default.
• W2890529589 countsByYear W28905295892019 @default.
• W2890529589 countsByYear W28905295892020 @default.
• W2890529589 countsByYear W28905295892021 @default.
• W2890529589 countsByYear W28905295892022 @default.
• W2890529589 countsByYear W28905295892023 @default.
• W2890529589 crossrefType "journal-article" @default.
• W2890529589 hasAuthorship W2890529589A5027121994 @default.
• W2890529589 hasAuthorship W2890529589A5033333203 @default.
• W2890529589 hasAuthorship W2890529589A5073753324 @default.
• W2890529589 hasAuthorship W2890529589A5082302003 @default.
• W2890529589 hasBestOaLocation W28905295891 @default.
• W2890529589 hasConcept C104317684 @default.
• W2890529589 hasConcept C105176652 @default.
• W2890529589 hasConcept C141231307 @default.
• W2890529589 hasConcept C189206191 @default.
• W2890529589 hasConcept C199360897 @default.
• W2890529589 hasConcept C2777904410 @default.
• W2890529589 hasConcept C41008148 @default.
• W2890529589 hasConcept C53702515 @default.
• W2890529589 hasConcept C54355233 @default.
• W2890529589 hasConcept C70721500 @default.
• W2890529589 hasConcept C86803240 @default.
• W2890529589 hasConceptScore W2890529589C104317684 @default.
• W2890529589 hasConceptScore W2890529589C105176652 @default.
• W2890529589 hasConceptScore W2890529589C141231307 @default.
• W2890529589 hasConceptScore W2890529589C189206191 @default.
• W2890529589 hasConceptScore W2890529589C199360897 @default.
• W2890529589 hasConceptScore W2890529589C2777904410 @default.
• W2890529589 hasConceptScore W2890529589C41008148 @default.
• W2890529589 hasConceptScore W2890529589C53702515 @default.
• W2890529589 hasConceptScore W2890529589C54355233 @default.
• W2890529589 hasConceptScore W2890529589C70721500 @default.
• W2890529589 hasConceptScore W2890529589C86803240 @default.
• W2890529589 hasLocation W28905295891 @default.
• W2890529589 hasLocation W28905295892 @default.
• W2890529589 hasLocation W28905295893 @default.

• next