Matches in SemOpenAlex for { <https://semopenalex.org/work/W2890920005> ?p ?o ?g. }
- W2890920005 endingPage "e0204356" @default.
- W2890920005 startingPage "e0204356" @default.
- W2890920005 abstract "Over 1 million metal-on-metal hip replacements were implanted. Even well-functioning implants produce wear debris that can cause tissue damage, disseminate and cause DNA damage. We aimed to establish if there was an association between metal-on-metal hip replacement and the risk of subsequently developing cancer compared with alternative hip replacements.We performed a population based prospective longitudinal cohort study using data from the National Joint Registry linked to Hospital Episode Statistics (n = 403,881 patients). We examined the incidence of a new diagnosis of cancer in patients who received a metal-on-metal bearing in comparison with those who received a non metal-on-metal bearing. Kaplan-Meier estimates of time to first cancer diagnosis were used with Cox proportional hazards regression models to assess the effect on the time to cancer diagnosis for all cancer types, haematological, malignant melanoma, urinary tract cancers or prostate cancer in men.The maximum follow up available was 11.8 years with 25% of patients followed up for more than 6.8 years (mean follow up 4.6 years; median 4.3; IQR 2.1-6.8; range 0.01-11.8). Analyses by gender that adjusted for age at primary and presence or absence of linked Welsh (PEDW) records showed no increase in the risk of developing cancer according to the bearing surface implanted for all cancers, haematological cancers, malignant melanoma, urinary tract cancers or prostate cancer in men. For patients receiving a second hip replacement, there was also no difference.We have demonstrated that there is currently no evidence of an increase in the risk of cancer following primary hip replacement according to the type of bearing material used. Although the risk of revision in metal-on-metal bearing hip replacements is higher, it is reassuring that the risk of a new diagnosis of cancer is not currently increased. Despite the long term follow up available in this study, the latency period for some cancers is very long and therefore continued monitoring is required to ensure no new patterns emerge that may indicate need for universal screening." @default.
- W2890920005 created "2018-09-27" @default.
- W2890920005 creator A5031306008 @default.
- W2890920005 creator A5067611937 @default.
- W2890920005 creator A5071306973 @default.
- W2890920005 creator A5072210649 @default.
- W2890920005 creator A5072895418 @default.
- W2890920005 date "2018-09-20" @default.
- W2890920005 modified "2023-10-18" @default.
- W2890920005 title "The risk of developing cancer following metal-on-metal hip replacement compared with non metal-on-metal hip bearings: Findings from a prospective national registry “The National Joint Registry of England, Wales, Northern Ireland and the Isle of Man”" @default.
- W2890920005 cites W1521836421 @default.
- W2890920005 cites W1546626815 @default.
- W2890920005 cites W1919665665 @default.
- W2890920005 cites W1987654721 @default.
- W2890920005 cites W2009466569 @default.
- W2890920005 cites W2029863590 @default.
- W2890920005 cites W2031647622 @default.
- W2890920005 cites W2035499342 @default.
- W2890920005 cites W2038981426 @default.
- W2890920005 cites W2054893537 @default.
- W2890920005 cites W2057503698 @default.
- W2890920005 cites W2058951377 @default.
- W2890920005 cites W2060392326 @default.
- W2890920005 cites W2080583768 @default.
- W2890920005 cites W2083636405 @default.
- W2890920005 cites W2105843439 @default.
- W2890920005 cites W2106733825 @default.
- W2890920005 cites W2109072509 @default.
- W2890920005 cites W2130830103 @default.
- W2890920005 cites W2131205777 @default.
- W2890920005 cites W2152785980 @default.
- W2890920005 cites W2153251751 @default.
- W2890920005 cites W2157568020 @default.
- W2890920005 cites W2167245867 @default.
- W2890920005 cites W2171106642 @default.
- W2890920005 cites W2171990013 @default.
- W2890920005 cites W2203539912 @default.
- W2890920005 cites W2267792456 @default.
- W2890920005 cites W2339483145 @default.
- W2890920005 cites W2548201432 @default.
- W2890920005 cites W2567606864 @default.
- W2890920005 cites W2781561625 @default.
- W2890920005 cites W2781678883 @default.
- W2890920005 cites W2782048185 @default.
- W2890920005 cites W2790694307 @default.
- W2890920005 cites W2792546015 @default.
- W2890920005 cites W2809574322 @default.
- W2890920005 doi "https://doi.org/10.1371/journal.pone.0204356" @default.
- W2890920005 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6147563" @default.
- W2890920005 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30235326" @default.
- W2890920005 hasPublicationYear "2018" @default.
- W2890920005 type Work @default.
- W2890920005 sameAs 2890920005 @default.
- W2890920005 citedByCount "16" @default.
- W2890920005 countsByYear W28909200052019 @default.
- W2890920005 countsByYear W28909200052020 @default.
- W2890920005 countsByYear W28909200052021 @default.
- W2890920005 countsByYear W28909200052022 @default.
- W2890920005 countsByYear W28909200052023 @default.
- W2890920005 crossrefType "journal-article" @default.
- W2890920005 hasAuthorship W2890920005A5031306008 @default.
- W2890920005 hasAuthorship W2890920005A5067611937 @default.
- W2890920005 hasAuthorship W2890920005A5071306973 @default.
- W2890920005 hasAuthorship W2890920005A5072210649 @default.
- W2890920005 hasAuthorship W2890920005A5072895418 @default.
- W2890920005 hasBestOaLocation W28909200051 @default.
- W2890920005 hasConcept C120665830 @default.
- W2890920005 hasConcept C121332964 @default.
- W2890920005 hasConcept C121608353 @default.
- W2890920005 hasConcept C126322002 @default.
- W2890920005 hasConcept C141071460 @default.
- W2890920005 hasConcept C188816634 @default.
- W2890920005 hasConcept C2778527826 @default.
- W2890920005 hasConcept C2780192828 @default.
- W2890920005 hasConcept C2908647359 @default.
- W2890920005 hasConcept C50382708 @default.
- W2890920005 hasConcept C61511704 @default.
- W2890920005 hasConcept C71924100 @default.
- W2890920005 hasConcept C99454951 @default.
- W2890920005 hasConceptScore W2890920005C120665830 @default.
- W2890920005 hasConceptScore W2890920005C121332964 @default.
- W2890920005 hasConceptScore W2890920005C121608353 @default.
- W2890920005 hasConceptScore W2890920005C126322002 @default.
- W2890920005 hasConceptScore W2890920005C141071460 @default.
- W2890920005 hasConceptScore W2890920005C188816634 @default.
- W2890920005 hasConceptScore W2890920005C2778527826 @default.
- W2890920005 hasConceptScore W2890920005C2780192828 @default.
- W2890920005 hasConceptScore W2890920005C2908647359 @default.
- W2890920005 hasConceptScore W2890920005C50382708 @default.
- W2890920005 hasConceptScore W2890920005C61511704 @default.
- W2890920005 hasConceptScore W2890920005C71924100 @default.
- W2890920005 hasConceptScore W2890920005C99454951 @default.
- W2890920005 hasFunder F4320319990 @default.
- W2890920005 hasIssue "9" @default.
- W2890920005 hasLocation W28909200051 @default.
- W2890920005 hasLocation W28909200052 @default.
- W2890920005 hasLocation W28909200053 @default.
- W2890920005 hasLocation W28909200054 @default.