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- W2891232912 abstract "A series of novel S-substituted 1H-3-R-5-mercapto-1,2,4-triazoles, obtained by docking based virtual screening (DBVS) of a previous constructed compound library, were synthesized and evaluated for their biological activities on a colorectal cancer cell line, HT-29. Among all synthesized compounds, TZ55.7, which was retained as a possible PDK1 (phospholipid-dependent kinase 1) inhibitor, exhibited the most significant cytotoxic activity against HT-29 tumor cell line. The same compound alongside other two, TZ53.7 and TZ3a.7, led to a significant cell cycle arrest in both sub G0/G1 and G0/G1 phase. This study provides future perspectives for the development of new agents containing the 1,2,4-mercapto triazole scaffold with antiproliferative activities in colorectal cancer." @default.
- W2891232912 created "2018-09-27" @default.
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- W2891232912 date "2018-08-23" @default.
- W2891232912 modified "2023-10-18" @default.
- W2891232912 title "Design, Synthesis and Biological Activity Evaluation of S-Substituted 1H-5-Mercapto-1,2,4-Triazole Derivatives as Antiproliferative Agents in Colorectal Cancer" @default.
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- W2891232912 doi "https://doi.org/10.3389/fchem.2018.00373" @default.
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