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- W2891857920 endingPage "177" @default.
- W2891857920 startingPage "168" @default.
- W2891857920 abstract "Biliary tract cancers (BTCs), including cholangiocarcinoma, gallbladder cancer and ampullary cancers, are poor-prognosis malignancies. Most patients are diagnosed with advanced disease, when treatment is limited to palliative chemotherapy. First line chemotherapy is usually administered in the form of cisplatin and gemcitabine. Benefit from second line chemotherapy is still to be confirmed. Even though new systemic treatment targets have been recognised, especially in patients with intrahepatic cholangiocarcinoma (e.g. IDH and FGFR), there is an urgent need for novel treatment strategies. Genomic profiling of BTC is progressively becoming a reality which allows a better understanding of their biology and potential new targets. This review provides an insight into DNA Damage Repair (DDR) mechanisms, prevalence of DDR-deficient tumours in BTC, and the potential role of DDR in cancer development. Some form of DDR deficiency is expected to be present in around 25% of patients with BTC, and this knowledge could be exploited to potentially increase response to currently-available treatment strategies (chemotherapy, radiotherapy or immunotherapy). For patients with DDR-proficient tumours, drug inhibition of DDR could be instituted." @default.
- W2891857920 created "2018-09-27" @default.
- W2891857920 creator A5003454059 @default.
- W2891857920 creator A5041768679 @default.
- W2891857920 creator A5060729173 @default.
- W2891857920 creator A5087850177 @default.
- W2891857920 date "2018-11-01" @default.
- W2891857920 modified "2023-10-18" @default.
- W2891857920 title "Biliary Tract Cancer: State of the Art and potential role of DNA Damage Repair" @default.
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