FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2892087916> ?p ?o ?g. }

• W2892087916 endingPage "e0204514" @default.
• W2892087916 startingPage "e0204514" @default.
• W2892087916 abstract "Pre-eclampsia is a hypertensive disorder of pregnancy characterised by hypertension and sodium retention by the kidneys. To identify changes in sodium uptake proteins in the tubules of the distal nephron, we studied their expression in urinary extracellular vesicles or exosomes (uEVs). Urine was collected from women with pre-eclampsia or during normal pregnancy, and from healthy non-pregnant controls. uEVs were isolated by centrifugation and analyzed by Western blot. Expression, proteolytic cleavage and phosphorylation was determined by densitometric analysis normalized to the exosome marker CD9. Results showed a significant increase in phosphorylation of the activating S130 site in NKCC2, the drug target for frusemide, in women with pre-eclampsia compared with normal pregnant women. Phosphorylation of the activating sites T101/105 in NKCC2 was similar but the activating T60 site in NCC, the drug target for thiazide diuretics, showed significantly less phosphorylation in pre-eclampsia compared with normal pregnancy. Expression of the larger forms of the α subunit of ENaC, the drug target for amiloride, was significantly greater in pre-eclampsia, with more fragmentation of theγ subunit. The differences observed are predicted to increase the activity of NKCC2 and ENaC while reducing that of NCC. This will increase sodium reabsorption, and so contribute to hypertension in pre-eclampsia." @default.
• W2892087916 created "2018-09-27" @default.
• W2892087916 creator A5001643442 @default.
• W2892087916 creator A5010978049 @default.
• W2892087916 creator A5015150869 @default.
• W2892087916 creator A5019420275 @default.
• W2892087916 creator A5024058809 @default.
• W2892087916 creator A5030625217 @default.
• W2892087916 creator A5031768593 @default.
• W2892087916 creator A5041119905 @default.
• W2892087916 creator A5051487043 @default.
• W2892087916 creator A5063478843 @default.
• W2892087916 creator A5075517781 @default.
• W2892087916 date "2018-09-24" @default.
• W2892087916 modified "2023-10-10" @default.
• W2892087916 title "Pre-eclampsia is associated with altered expression of the renal sodium transporters NKCC2, NCC and ENaC in urinary extracellular vesicles" @default.
• W2892087916 cites W1505008375 @default.
• W2892087916 cites W1827729646 @default.
• W2892087916 cites W1877686344 @default.
• W2892087916 cites W1964337743 @default.
• W2892087916 cites W1983019832 @default.
• W2892087916 cites W1996856159 @default.
• W2892087916 cites W2004706099 @default.
• W2892087916 cites W2006522274 @default.
• W2892087916 cites W2020953798 @default.
• W2892087916 cites W2021407435 @default.
• W2892087916 cites W2021613039 @default.
• W2892087916 cites W2036954961 @default.
• W2892087916 cites W2041640014 @default.
• W2892087916 cites W2063621077 @default.
• W2892087916 cites W2078424563 @default.
• W2892087916 cites W2099603281 @default.
• W2892087916 cites W2106301231 @default.
• W2892087916 cites W2108579765 @default.
• W2892087916 cites W2111397256 @default.
• W2892087916 cites W2116215226 @default.
• W2892087916 cites W2122704962 @default.
• W2892087916 cites W2124663880 @default.
• W2892087916 cites W2129062330 @default.
• W2892087916 cites W2130327173 @default.
• W2892087916 cites W2141617464 @default.
• W2892087916 cites W2143180984 @default.
• W2892087916 cites W2147736218 @default.
• W2892087916 cites W2150551377 @default.
• W2892087916 cites W2169090946 @default.
• W2892087916 cites W2216243113 @default.
• W2892087916 cites W2230764365 @default.
• W2892087916 cites W2274714300 @default.
• W2892087916 cites W2314813180 @default.
• W2892087916 cites W2413333366 @default.
• W2892087916 cites W2465200336 @default.
• W2892087916 cites W2606303128 @default.
• W2892087916 cites W4300666291 @default.
• W2892087916 cites W2213193092 @default.
• W2892087916 doi "https://doi.org/10.1371/journal.pone.0204514" @default.
• W2892087916 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6152984" @default.
• W2892087916 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30248150" @default.
• W2892087916 hasPublicationYear "2018" @default.
• W2892087916 type Work @default.
• W2892087916 sameAs 2892087916 @default.
• W2892087916 citedByCount "29" @default.
• W2892087916 countsByYear W28920879162019 @default.
• W2892087916 countsByYear W28920879162020 @default.
• W2892087916 countsByYear W28920879162021 @default.
• W2892087916 countsByYear W28920879162022 @default.
• W2892087916 countsByYear W28920879162023 @default.
• W2892087916 crossrefType "journal-article" @default.
• W2892087916 hasAuthorship W2892087916A5001643442 @default.
• W2892087916 hasAuthorship W2892087916A5010978049 @default.
• W2892087916 hasAuthorship W2892087916A5015150869 @default.
• W2892087916 hasAuthorship W2892087916A5019420275 @default.
• W2892087916 hasAuthorship W2892087916A5024058809 @default.
• W2892087916 hasAuthorship W2892087916A5030625217 @default.
• W2892087916 hasAuthorship W2892087916A5031768593 @default.
• W2892087916 hasAuthorship W2892087916A5041119905 @default.
• W2892087916 hasAuthorship W2892087916A5051487043 @default.
• W2892087916 hasAuthorship W2892087916A5063478843 @default.
• W2892087916 hasAuthorship W2892087916A5075517781 @default.
• W2892087916 hasBestOaLocation W28920879161 @default.
• W2892087916 hasConcept C11960822 @default.
• W2892087916 hasConcept C126322002 @default.
• W2892087916 hasConcept C134018914 @default.
• W2892087916 hasConcept C170493617 @default.
• W2892087916 hasConcept C178790620 @default.
• W2892087916 hasConcept C185592680 @default.
• W2892087916 hasConcept C2778525890 @default.
• W2892087916 hasConcept C2779234561 @default.
• W2892087916 hasConcept C2781276381 @default.
• W2892087916 hasConcept C2908929049 @default.
• W2892087916 hasConcept C537181965 @default.
• W2892087916 hasConcept C54355233 @default.
• W2892087916 hasConcept C55493867 @default.
• W2892087916 hasConcept C6507245 @default.
• W2892087916 hasConcept C71924100 @default.
• W2892087916 hasConcept C86803240 @default.
• W2892087916 hasConceptScore W2892087916C11960822 @default.
• W2892087916 hasConceptScore W2892087916C126322002 @default.
• W2892087916 hasConceptScore W2892087916C134018914 @default.

• next