Matches in SemOpenAlex for { <https://semopenalex.org/work/W2892282900> ?p ?o ?g. }
- W2892282900 endingPage "1046" @default.
- W2892282900 startingPage "1035" @default.
- W2892282900 abstract "Chronic wounds are a significant health care problem with serious implications for quality of life because they do not properly heal and often require therapeutic intervention. Amniotic membrane allografts have been successfully used as a biologic therapy to promote soft tissue healing; however, the umbilical cord, another placental-derived tissue, has also recently garnered interest because of its unique composition but similar placental tissue origin. The aim of this study was to characterize PURION® PLUS Processed dehydrated human umbilical cord (dHUC) and evaluate the biological properties of this tissue that contribute to healing. This was performed through the characterization of the tissue composition, evaluation of in vitro cellular response to dHUC treatment, and in vivo bioresorption and tissue response in a rat model. It was observed that dHUC contains collagen I, hyaluronic acid, laminin, and fibronectin. Additionally, 461 proteins that consist of growth factors and cytokines, inflammatory modulators, chemokines, proteases and inhibitors, adhesion molecules, signaling receptors, membrane-bound proteins, and other soluble regulators were detected. Cell-based assays demonstrated an increase in adipose-derived stem cell and mesenchymal stem cell proliferation, fibroblast migration and endothelial progenitor cell vessel formation in a dose-dependent manner after dHUC treatment. Lastly, rat subcutaneous implantation demonstrated biocompatibility since dHUC allografts were resorbed without fibrous encapsulation. These findings establish that dHUC possesses biological properties that stimulate cellular responses important for soft tissue healing. © 2018 The Authors. Journal Of Biomedical Materials Research Part B: Applied Biomaterials Published By Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 107B: 1035-1046, 2019." @default.
- W2892282900 created "2018-09-27" @default.
- W2892282900 creator A5019104197 @default.
- W2892282900 creator A5025485973 @default.
- W2892282900 creator A5046932964 @default.
- W2892282900 creator A5056961606 @default.
- W2892282900 creator A5063420325 @default.
- W2892282900 creator A5070906069 @default.
- W2892282900 date "2018-09-10" @default.
- W2892282900 modified "2023-10-10" @default.
- W2892282900 title "Evaluation of dehydrated human umbilical cord biological properties for wound care and soft tissue healing" @default.
- W2892282900 cites W1548205289 @default.
- W2892282900 cites W1576283994 @default.
- W2892282900 cites W1593599570 @default.
- W2892282900 cites W1938683170 @default.
- W2892282900 cites W1949832432 @default.
- W2892282900 cites W1953519918 @default.
- W2892282900 cites W1965917470 @default.
- W2892282900 cites W1970964721 @default.
- W2892282900 cites W1990386050 @default.
- W2892282900 cites W1995857537 @default.
- W2892282900 cites W2005101455 @default.
- W2892282900 cites W2013322971 @default.
- W2892282900 cites W2018845229 @default.
- W2892282900 cites W2028543411 @default.
- W2892282900 cites W2030160629 @default.
- W2892282900 cites W2032619835 @default.
- W2892282900 cites W2046596640 @default.
- W2892282900 cites W2057055923 @default.
- W2892282900 cites W2084334139 @default.
- W2892282900 cites W2084740377 @default.
- W2892282900 cites W2095212309 @default.
- W2892282900 cites W2103876799 @default.
- W2892282900 cites W2103984819 @default.
- W2892282900 cites W2104330540 @default.
- W2892282900 cites W2106440605 @default.
- W2892282900 cites W2110659551 @default.
- W2892282900 cites W2114425621 @default.
- W2892282900 cites W2118414375 @default.
- W2892282900 cites W2126067465 @default.
- W2892282900 cites W2137832464 @default.
- W2892282900 cites W2142605112 @default.
- W2892282900 cites W2144612234 @default.
- W2892282900 cites W2153608588 @default.
- W2892282900 cites W2157503206 @default.
- W2892282900 cites W2159435955 @default.
- W2892282900 cites W2227277616 @default.
- W2892282900 cites W2261152580 @default.
- W2892282900 cites W2315246287 @default.
- W2892282900 cites W2402202411 @default.
- W2892282900 cites W2436183129 @default.
- W2892282900 cites W2470534966 @default.
- W2892282900 cites W2526492619 @default.
- W2892282900 cites W2551937465 @default.
- W2892282900 cites W2595834205 @default.
- W2892282900 cites W2761355671 @default.
- W2892282900 doi "https://doi.org/10.1002/jbm.b.34196" @default.
- W2892282900 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6585686" @default.
- W2892282900 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30199609" @default.
- W2892282900 hasPublicationYear "2018" @default.
- W2892282900 type Work @default.
- W2892282900 sameAs 2892282900 @default.
- W2892282900 citedByCount "22" @default.
- W2892282900 countsByYear W28922829002018 @default.
- W2892282900 countsByYear W28922829002020 @default.
- W2892282900 countsByYear W28922829002021 @default.
- W2892282900 countsByYear W28922829002022 @default.
- W2892282900 countsByYear W28922829002023 @default.
- W2892282900 crossrefType "journal-article" @default.
- W2892282900 hasAuthorship W2892282900A5019104197 @default.
- W2892282900 hasAuthorship W2892282900A5025485973 @default.
- W2892282900 hasAuthorship W2892282900A5046932964 @default.
- W2892282900 hasAuthorship W2892282900A5056961606 @default.
- W2892282900 hasAuthorship W2892282900A5063420325 @default.
- W2892282900 hasAuthorship W2892282900A5070906069 @default.
- W2892282900 hasBestOaLocation W28922829001 @default.
- W2892282900 hasConcept C136229726 @default.
- W2892282900 hasConcept C181199279 @default.
- W2892282900 hasConcept C182220744 @default.
- W2892282900 hasConcept C189165786 @default.
- W2892282900 hasConcept C192562407 @default.
- W2892282900 hasConcept C198826908 @default.
- W2892282900 hasConcept C203014093 @default.
- W2892282900 hasConcept C2780269544 @default.
- W2892282900 hasConcept C28328180 @default.
- W2892282900 hasConcept C49892992 @default.
- W2892282900 hasConcept C55493867 @default.
- W2892282900 hasConcept C71924100 @default.
- W2892282900 hasConcept C86492073 @default.
- W2892282900 hasConcept C86803240 @default.
- W2892282900 hasConcept C95444343 @default.
- W2892282900 hasConceptScore W2892282900C136229726 @default.
- W2892282900 hasConceptScore W2892282900C181199279 @default.
- W2892282900 hasConceptScore W2892282900C182220744 @default.
- W2892282900 hasConceptScore W2892282900C189165786 @default.
- W2892282900 hasConceptScore W2892282900C192562407 @default.
- W2892282900 hasConceptScore W2892282900C198826908 @default.
- W2892282900 hasConceptScore W2892282900C203014093 @default.