FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2893229687> ?p ?o ?g. }

• W2893229687 endingPage "149" @default.
• W2893229687 startingPage "137" @default.
• W2893229687 abstract "Abstract Context Altered expression of the insulin receptor (IR) in adipose tissue (AT) could contribute to gestational diabetes mellitus (GDM) etiopathogenesis. Transcriptional regulation via epigenetic mechanisms (e.g., DNA methylation) may play a critical role. However, the human IR promoter DNA methylation patterns and involvement in gene expression are unknown. Objective We evaluated IR mRNA and protein expression accompanied by targeted DNA methylation analyses in AT and blood cells of women with GDM and their offspring. Design Prospective observational study. Setting Academic clinic and research unit. Participants GDM-affected (n = 25) and matched control (n = 30) mother-child dyads. Main Outcome Measures Maternal IR gene and protein expression in paired subcutaneous (SAT) and visceral adipose tissue samples (VAT). DNA methylation levels in IR promoter and intronic regions in maternal AT and blood cells of mother-offspring pairs. Results In SAT and VAT, IR mRNA/protein expressions were significantly reduced in women with GDMs (P &lt; 0.05). The decrease in VAT was more pronounced and independent of maternal body mass index. VAT IR protein levels were inversely associated with key maternal and neonatal anthropometric and metabolic parameters (P &lt; 0.05). DNA methylation patterns were similar across tissues, with significant yet small size alterations between groups in mothers and offspring (P &lt; 0.05). Conclusion Decreased IR levels in AT may be a relevant pathogenic factor in GDM, affecting materno-fetal metabolism. Further investigation of causal factors for IR dysregulation is necessary, especially in VAT. Potential functional and/or clinical roles of altered DNA methylation also should be evaluated." @default.
• W2893229687 created "2018-10-05" @default.
• W2893229687 creator A5003903724 @default.
• W2893229687 creator A5009392053 @default.
• W2893229687 creator A5021248782 @default.
• W2893229687 creator A5023771313 @default.
• W2893229687 creator A5057771485 @default.
• W2893229687 creator A5068954166 @default.
• W2893229687 creator A5082232751 @default.
• W2893229687 creator A5085309504 @default.
• W2893229687 date "2018-09-26" @default.
• W2893229687 modified "2023-10-03" @default.
• W2893229687 title "Reduced Insulin Receptor Expression and Altered DNA Methylation in Fat Tissues and Blood of Women With GDM and Offspring" @default.
• W2893229687 cites W1515512355 @default.
• W2893229687 cites W1543414397 @default.
• W2893229687 cites W1551182844 @default.
• W2893229687 cites W1769940351 @default.
• W2893229687 cites W1965359249 @default.
• W2893229687 cites W1966198968 @default.
• W2893229687 cites W1978667553 @default.
• W2893229687 cites W1997113758 @default.
• W2893229687 cites W2002497778 @default.
• W2893229687 cites W2012037560 @default.
• W2893229687 cites W2051051060 @default.
• W2893229687 cites W2074076323 @default.
• W2893229687 cites W2079577144 @default.
• W2893229687 cites W2100701743 @default.
• W2893229687 cites W2101648470 @default.
• W2893229687 cites W2104476055 @default.
• W2893229687 cites W2112752274 @default.
• W2893229687 cites W2114377124 @default.
• W2893229687 cites W2114819974 @default.
• W2893229687 cites W2118456958 @default.
• W2893229687 cites W2119552042 @default.
• W2893229687 cites W2123032740 @default.
• W2893229687 cites W2125767272 @default.
• W2893229687 cites W2125852509 @default.
• W2893229687 cites W2128016314 @default.
• W2893229687 cites W2141810686 @default.
• W2893229687 cites W2154970636 @default.
• W2893229687 cites W2156877200 @default.
• W2893229687 cites W2160234571 @default.
• W2893229687 cites W2166256210 @default.
• W2893229687 cites W2169580912 @default.
• W2893229687 cites W2529659365 @default.
• W2893229687 cites W2531363533 @default.
• W2893229687 cites W2600840322 @default.
• W2893229687 cites W2607375504 @default.
• W2893229687 cites W2808721932 @default.
• W2893229687 doi "https://doi.org/10.1210/jc.2018-01659" @default.
• W2893229687 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30260402" @default.
• W2893229687 hasPublicationYear "2018" @default.
• W2893229687 type Work @default.
• W2893229687 sameAs 2893229687 @default.
• W2893229687 citedByCount "24" @default.
• W2893229687 countsByYear W28932296872019 @default.
• W2893229687 countsByYear W28932296872020 @default.
• W2893229687 countsByYear W28932296872021 @default.
• W2893229687 countsByYear W28932296872022 @default.
• W2893229687 countsByYear W28932296872023 @default.
• W2893229687 crossrefType "journal-article" @default.
• W2893229687 hasAuthorship W2893229687A5003903724 @default.
• W2893229687 hasAuthorship W2893229687A5009392053 @default.
• W2893229687 hasAuthorship W2893229687A5021248782 @default.
• W2893229687 hasAuthorship W2893229687A5023771313 @default.
• W2893229687 hasAuthorship W2893229687A5057771485 @default.
• W2893229687 hasAuthorship W2893229687A5068954166 @default.
• W2893229687 hasAuthorship W2893229687A5082232751 @default.
• W2893229687 hasAuthorship W2893229687A5085309504 @default.
• W2893229687 hasBestOaLocation W28932296871 @default.
• W2893229687 hasConcept C101762097 @default.
• W2893229687 hasConcept C104317684 @default.
• W2893229687 hasConcept C112672928 @default.
• W2893229687 hasConcept C126322002 @default.
• W2893229687 hasConcept C134018914 @default.
• W2893229687 hasConcept C150194340 @default.
• W2893229687 hasConcept C151730666 @default.
• W2893229687 hasConcept C171089720 @default.
• W2893229687 hasConcept C190727270 @default.
• W2893229687 hasConcept C2779234561 @default.
• W2893229687 hasConcept C2779343474 @default.
• W2893229687 hasConcept C2779434492 @default.
• W2893229687 hasConcept C33288867 @default.
• W2893229687 hasConcept C41091548 @default.
• W2893229687 hasConcept C46973012 @default.
• W2893229687 hasConcept C54355233 @default.
• W2893229687 hasConcept C71924100 @default.
• W2893229687 hasConcept C86803240 @default.
• W2893229687 hasConceptScore W2893229687C101762097 @default.
• W2893229687 hasConceptScore W2893229687C104317684 @default.
• W2893229687 hasConceptScore W2893229687C112672928 @default.
• W2893229687 hasConceptScore W2893229687C126322002 @default.
• W2893229687 hasConceptScore W2893229687C134018914 @default.
• W2893229687 hasConceptScore W2893229687C150194340 @default.
• W2893229687 hasConceptScore W2893229687C151730666 @default.
• W2893229687 hasConceptScore W2893229687C171089720 @default.
• W2893229687 hasConceptScore W2893229687C190727270 @default.
• W2893229687 hasConceptScore W2893229687C2779234561 @default.

• next