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• W2894365725 abstract "Glomerular immunoglobulin A (IgA) deposition is a common finding in hepatic glomerulosclerosis; thus, this disease is also called hepatic IgA nephropathy. However, only a small number of patients with hepatic IgA nephropathy have active glomerular lesions, so functional decline is slow in most cases. In this report, we describe a 60-year-old man who developed nephrotic syndrome and progressive renal impairment during follow-up for alcoholic liver cirrhosis. A renal biopsy showed a membranoproliferative glomerulonephritis-like pattern; diffuse double-contours of the glomerular basement membrane and focal active glomerular lesions with moderate-to-severe endocapillary proliferation and fibrocellular crescents. Immunofluorescence findings revealed granular staining for monoclonal IgA1- κ and C3 on the peripheral capillary walls. Laboratory examinations did not reveal any definitive evidence of myeloproliferative disorders. Therefore, this case may represent a previously unrecognized etiology of renal injury in relation to liver cirrhosis that is characterized by monoclonal IgA1- κ deposits and proliferative glomerulonephritis." @default.
• W2894365725 created "2018-10-05" @default.
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• W2894365725 date "2018-10-01" @default.
• W2894365725 modified "2023-10-16" @default.
• W2894365725 title "A Case of Hepatic Glomerulosclerosis with Monoclonal IgA1-κ Deposits" @default.
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• W2894365725 doi "https://doi.org/10.1155/2018/4748357" @default.
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