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• W2894413552 abstract "Porphyromonas gingivalis is considered the principal etiologic agent and keystone pathogen of chronic periodontitis. As an auxotrophic bacterium, it must acquire heme to survive and multiply at the infection site. P. gingivalis HmuY is the first member of a novel family of hemophore-like proteins. Bacterial heme-binding proteins usually use histidine-methionine or histidine-tyrosine residues to ligate heme-iron, whereas P. gingivalis HmuY uses two histidine residues. We hypothesized that other ‘red complex’ members, i.e. Tannerella forsythia and Treponema denticola might utilize similar heme uptake mechanisms to the P. gingivalis HmuY. Comparative and phylogenetic analyses suggested differentiation of HmuY homologs and low conservation of heme-coordinating histidine residues present in HmuY. The homologs were subjected to duplication before divergence of Bacteroidetes lineages, which could facilitate evolution of functional diversification. We found that T. denticola does not code an HmuY homolog. T. forsythia protein, termed as Tfo, binds heme, but preferentially in the ferrous form, and sequesters heme from the albumin–heme complex under reducing conditions. In agreement with that, the 3D structure of Tfo differs from that of HmuY in the folding of heme-binding pocket, containing two methionine residues instead of two histidine residues coordinating heme in HmuY. Heme binding to apo-HmuY is accompanied by movement of the loop carrying the His166 residue, closing the heme-binding pocket. Molecular dynamics simulations (MD) demonstrated that this conformational change also occurs in Tfo. In conclusion, our findings suggest that HmuY-like family might comprise proteins subjected during evolution to significant diversification, resulting in different heme-binding properties." @default.
• W2894413552 created "2018-10-05" @default.
• W2894413552 creator A5002308171 @default.
• W2894413552 creator A5011897079 @default.
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• W2894413552 creator A5086095536 @default.
• W2894413552 date "2018-10-23" @default.
• W2894413552 modified "2023-09-27" @default.
• W2894413552 title "<i>Tannerella forsythia</i> Tfo belongs to <i>Porphyromonas gingivalis</i> HmuY-like family of proteins but differs in heme-binding properties" @default.
• W2894413552 cites W1031578623 @default.
• W2894413552 cites W1539796472 @default.
• W2894413552 cites W1566515137 @default.
• W2894413552 cites W1599479604 @default.
• W2894413552 cites W1753315648 @default.
• W2894413552 cites W1855914786 @default.
• W2894413552 cites W1861622576 @default.
• W2894413552 cites W1895718854 @default.
• W2894413552 cites W1900702673 @default.
• W2894413552 cites W1964079055 @default.
• W2894413552 cites W1968271177 @default.
• W2894413552 cites W1972001117 @default.
• W2894413552 cites W1976819810 @default.
• W2894413552 cites W1988160707 @default.
• W2894413552 cites W1993426964 @default.
• W2894413552 cites W1994967847 @default.
• W2894413552 cites W1997725099 @default.
• W2894413552 cites W2000524912 @default.
• W2894413552 cites W2000749448 @default.
• W2894413552 cites W2004075830 @default.
• W2894413552 cites W2005877813 @default.
• W2894413552 cites W2008294135 @default.
• W2894413552 cites W2009798288 @default.
• W2894413552 cites W2022361901 @default.
• W2894413552 cites W2029667189 @default.
• W2894413552 cites W2030768253 @default.
• W2894413552 cites W2035353182 @default.
• W2894413552 cites W2035503835 @default.
• W2894413552 cites W2035687084 @default.
• W2894413552 cites W2041089815 @default.
• W2894413552 cites W2045623041 @default.
• W2894413552 cites W2058226623 @default.
• W2894413552 cites W2060182219 @default.
• W2894413552 cites W2062072956 @default.
• W2894413552 cites W2064228141 @default.
• W2894413552 cites W2067020332 @default.
• W2894413552 cites W206775021 @default.
• W2894413552 cites W2068222694 @default.
• W2894413552 cites W2071877589 @default.
• W2894413552 cites W2072378500 @default.
• W2894413552 cites W2073429226 @default.
• W2894413552 cites W2077124327 @default.
• W2894413552 cites W2081693079 @default.
• W2894413552 cites W2083510026 @default.
• W2894413552 cites W2086953830 @default.
• W2894413552 cites W2087091587 @default.
• W2894413552 cites W2092558155 @default.
• W2894413552 cites W2098448352 @default.
• W2894413552 cites W2098621162 @default.
• W2894413552 cites W2110808180 @default.
• W2894413552 cites W2111211467 @default.
• W2894413552 cites W2111647009 @default.
• W2894413552 cites W2113776769 @default.
• W2894413552 cites W2119158447 @default.
• W2894413552 cites W2119978331 @default.
• W2894413552 cites W2120772351 @default.
• W2894413552 cites W2121491059 @default.
• W2894413552 cites W2122339645 @default.
• W2894413552 cites W2124026197 @default.
• W2894413552 cites W2126470914 @default.
• W2894413552 cites W2133312664 @default.
• W2894413552 cites W2139134537 @default.
• W2894413552 cites W2139796302 @default.
• W2894413552 cites W2143254097 @default.
• W2894413552 cites W2143996952 @default.
• W2894413552 cites W2144362290 @default.
• W2894413552 cites W2147307434 @default.
• W2894413552 cites W2148698435 @default.
• W2894413552 cites W2153544371 @default.
• W2894413552 cites W2157107389 @default.
• W2894413552 cites W2159211495 @default.
• W2894413552 cites W2160378127 @default.
• W2894413552 cites W2168170465 @default.
• W2894413552 cites W2169490506 @default.
• W2894413552 cites W2169732730 @default.
• W2894413552 cites W2170400151 @default.
• W2894413552 cites W2192030661 @default.
• W2894413552 cites W2275032145 @default.
• W2894413552 cites W2316646952 @default.
• W2894413552 cites W2327990018 @default.
• W2894413552 cites W2339807897 @default.
• W2894413552 cites W2614081736 @default.
• W2894413552 cites W4246448952 @default.
• W2894413552 cites W4248872320 @default.
• W2894413552 doi "https://doi.org/10.1042/bsr20181325" @default.
• W2894413552 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6200708" @default.

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