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- W2895979896 abstract "Theionbrunonines A and B (1 and 2), the first examples of monoterpene bisindole alkaloids linked by a thioether bridge, were isolated from the stems of Mostuea brunonis, guided by a molecular networking-based dereplication strategy. Their structures were elucidated by a combination of spectroscopic data and ECD calculations. A plausible biosynthetic pathway for 1 and 2 was postulated. Theionbrunonines A and B (1 and 2) showed moderate antiplasmodial activities in the micromolar range against the strain FcB1 of Plasmodium falciparum and no cytotoxic activity against the MRC-5 cell line at 20 μM." @default.
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- W2895979896 date "2018-10-10" @default.
- W2895979896 modified "2023-09-26" @default.
- W2895979896 title "Theionbrunonines A and B: Dimeric Vobasine Alkaloids Tethered by a Thioether Bridge from <i>Mostuea brunonis</i>" @default.
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- W2895979896 doi "https://doi.org/10.1021/acs.orglett.8b02961" @default.
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