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- W2896667558 abstract "SNARE proteins constitute the core of the exocytotic membrane fusion machinery. Fusion occurs when vesicle-associated and target membrane-associated SNAREs zipper into trans-SNARE complexes ('SNAREpins'), but the number required is controversial and the mechanism of cooperative fusion is poorly understood. We developed a highly coarse-grained molecular dynamics simulation to access the long fusion timescales, which revealed a two-stage process. First, zippering energy was dissipated and cooperative entropic forces assembled the SNAREpins into a ring; second, entropic forces expanded the ring, pressing membranes together and catalyzing fusion. We predict that any number of SNAREs fuses membranes, but fusion is faster with more SNAREs." @default.
- W2896667558 created "2018-10-26" @default.
- W2896667558 creator A5011948483 @default.
- W2896667558 creator A5021694109 @default.
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- W2896667558 date "2018-11-01" @default.
- W2896667558 modified "2023-10-16" @default.
- W2896667558 title "SNARE-mediated membrane fusion is a two-stage process driven by entropic forces" @default.
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- W2896667558 doi "https://doi.org/10.1002/1873-3468.13277" @default.
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