Matches in SemOpenAlex for { <https://semopenalex.org/work/W2897570149> ?p ?o ?g. }
- W2897570149 endingPage "505" @default.
- W2897570149 startingPage "488" @default.
- W2897570149 abstract "Abstract Locoregional recurrence negatively impacts both long‐term survival and quality of life for several malignancies. For appropriate‐risk patients with an isolated, resectable, local recurrence, surgery represents the only potentially curative therapy. However, oncologic outcomes remain inferior for patients with locally recurrent disease even after macroscopically complete resection. Unfortunately, these operations are often extensive, with significant perioperative morbidity and mortality. This review highlights selected malignancies (mesothelioma, sarcoma, lung cancer, breast cancer, rectal cancer, and peritoneal surface malignancies) in which surgical resection is a key treatment modality and local recurrence plays a significant role in overall oncologic outcome with regard to survival and quality of life. For each type of cancer, the current, state‐of‐the‐art treatment strategies and their outcomes are assessed. The need for additional therapeutic options is presented given the limitations of the current standard therapies. New and emerging treatment modalities, including polymer films and nanoparticles, are highlighted as potential future solutions for both prevention and treatment of locally recurrent cancers. Finally, the authors identify additional clinical and research opportunities and propose future research strategies based on the various patterns of local recurrence among the different cancers." @default.
- W2897570149 created "2018-10-26" @default.
- W2897570149 creator A5016461513 @default.
- W2897570149 creator A5018636031 @default.
- W2897570149 creator A5034925727 @default.
- W2897570149 creator A5056266239 @default.
- W2897570149 creator A5067693820 @default.
- W2897570149 date "2018-10-17" @default.
- W2897570149 modified "2023-10-16" @default.
- W2897570149 title "Local Cancer Recurrence: The Realities, Challenges, and Opportunities for New Therapies" @default.
- W2897570149 cites W1135720400 @default.
- W2897570149 cites W1503350484 @default.
- W2897570149 cites W1529985444 @default.
- W2897570149 cites W1650741782 @default.
- W2897570149 cites W1774507721 @default.
- W2897570149 cites W1948261638 @default.
- W2897570149 cites W1954070773 @default.
- W2897570149 cites W1969230931 @default.
- W2897570149 cites W1972827121 @default.
- W2897570149 cites W1975727847 @default.
- W2897570149 cites W1977376622 @default.
- W2897570149 cites W1981396218 @default.
- W2897570149 cites W1982623790 @default.
- W2897570149 cites W1986993149 @default.
- W2897570149 cites W1988071238 @default.
- W2897570149 cites W1989589777 @default.
- W2897570149 cites W1994210154 @default.
- W2897570149 cites W1994936258 @default.
- W2897570149 cites W2000687665 @default.
- W2897570149 cites W2009097203 @default.
- W2897570149 cites W2009903688 @default.
- W2897570149 cites W2009906157 @default.
- W2897570149 cites W2017527202 @default.
- W2897570149 cites W2022617644 @default.
- W2897570149 cites W2024944973 @default.
- W2897570149 cites W2025363647 @default.
- W2897570149 cites W2027147390 @default.
- W2897570149 cites W2027387219 @default.
- W2897570149 cites W2032152459 @default.
- W2897570149 cites W2036311740 @default.
- W2897570149 cites W2042210669 @default.
- W2897570149 cites W2043276864 @default.
- W2897570149 cites W2044411373 @default.
- W2897570149 cites W2044601095 @default.
- W2897570149 cites W2044679247 @default.
- W2897570149 cites W2045839111 @default.
- W2897570149 cites W2046940607 @default.
- W2897570149 cites W2047835406 @default.
- W2897570149 cites W2052847721 @default.
- W2897570149 cites W2057604474 @default.
- W2897570149 cites W2058002784 @default.
- W2897570149 cites W2058147567 @default.
- W2897570149 cites W2060760531 @default.
- W2897570149 cites W2064543762 @default.
- W2897570149 cites W2064638989 @default.
- W2897570149 cites W2066364033 @default.
- W2897570149 cites W2066940652 @default.
- W2897570149 cites W2067420088 @default.
- W2897570149 cites W2069111865 @default.
- W2897570149 cites W2070544966 @default.
- W2897570149 cites W2074817750 @default.
- W2897570149 cites W2077428858 @default.
- W2897570149 cites W2077513695 @default.
- W2897570149 cites W2080737046 @default.
- W2897570149 cites W2086941176 @default.
- W2897570149 cites W2096785769 @default.
- W2897570149 cites W2097198751 @default.
- W2897570149 cites W2098225751 @default.
- W2897570149 cites W2100025800 @default.
- W2897570149 cites W2101603546 @default.
- W2897570149 cites W2102627969 @default.
- W2897570149 cites W2103006031 @default.
- W2897570149 cites W2104142393 @default.
- W2897570149 cites W2104440842 @default.
- W2897570149 cites W2107710830 @default.
- W2897570149 cites W2113220153 @default.
- W2897570149 cites W2113817061 @default.
- W2897570149 cites W2114323833 @default.
- W2897570149 cites W2116683035 @default.
- W2897570149 cites W2120901491 @default.
- W2897570149 cites W2127231441 @default.
- W2897570149 cites W2129825983 @default.
- W2897570149 cites W2131719808 @default.
- W2897570149 cites W2132314250 @default.
- W2897570149 cites W2136344041 @default.
- W2897570149 cites W2137049867 @default.
- W2897570149 cites W2137205222 @default.
- W2897570149 cites W2140169871 @default.
- W2897570149 cites W2140282699 @default.
- W2897570149 cites W2142818315 @default.
- W2897570149 cites W2144713193 @default.
- W2897570149 cites W2147329481 @default.
- W2897570149 cites W2149273511 @default.
- W2897570149 cites W2152023523 @default.
- W2897570149 cites W2152969899 @default.
- W2897570149 cites W2156062771 @default.
- W2897570149 cites W2156196788 @default.
- W2897570149 cites W2158408253 @default.