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- W2897948395 abstract "The endoplasmic reticulum (ER) is critical in protein processing and particularly in ensuring that proteins undergo their correct folding to exert their functionality. What is becoming increasingly clear is that the ER may undergo increasing stress brought about by nutrient deprivation, hypoxia, oxidized lipids, point mutations in secreted proteins, cellular differentiation or significant deviation from metabolic set points, and loss of Ca2+ homeostasis, with detrimental effects on ER-resident calcium-dependent chaperones, alone or in combination. This results in the unfolded protein response (UPR) that is a repair mechanism to limit the formation of newly damaged proteins until ER homeostasis is restored, though may result in increased cell death. ER stress has been shown to be implicated in a variety of diseases. Statins are well-known cholesterol-lowering drugs and have been extensively reported to possess beneficial cholesterol-independent effects in a variety of human diseases. This review focuses on the concept of ER stress, the underlying molecular mechanisms and their relationship to the pathophysiology and, finally, the role of statins in moderating ER stress and UPR." @default.
- W2897948395 created "2018-10-26" @default.
- W2897948395 creator A5012961676 @default.
- W2897948395 creator A5022387451 @default.
- W2897948395 creator A5023255400 @default.
- W2897948395 creator A5036163332 @default.
- W2897948395 creator A5055297639 @default.
- W2897948395 creator A5074208520 @default.
- W2897948395 date "2018-11-01" @default.
- W2897948395 modified "2023-09-23" @default.
- W2897948395 title "The effect of statin therapy on endoplasmic reticulum stress" @default.
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