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• W2899243374 endingPage "273" @default.
• W2899243374 startingPage "259" @default.
• W2899243374 abstract "Osteoporosis is a common bone disorder that increases susceptibility to fragility bone fractures. The clinical and public health repercussions of osteoporosis are huge due to the morbidity, mortality, and cost of medical care linked with fragility fractures. Clinical assessment of osteoporotic risk factors can help to identify candidates at an early stage that will benefit from medical intervention and potentially lowering the morbidity and mortality seen with fractures and complications. Given this, research is ongoing to evaluate the association of osteoporosis with some novel or less well-studied risk factors/bio-markers such as uric acid (UA).Uric acid's antioxidant activity has been proposed to be one of the factors responsible for increasing longevity and lowering rates of age-related cancers during primate evolution, the level of which increased markedly due to loss of uricase enzyme activity (mutational silencing). Accumulated evidence shows that oxidative stress is the fundamental mechanism of age-related bone loss and acts via enhancing osteoclastic activity and increasing bone resorption. Antioxidant substances such as ascorbic acid scavenge free radicals are positively related to bone health. Thus, it is hypothesized that uric acid holds bone-protective potential owing to its potent antioxidative property. Several correlation studies have been conducted globally to investigate the relationship between serum uric acid with bone mineral density and osteoporosis. Few pre-clinical studies have tried to investigate the interaction between uric acid and bone mineral density and reported important role played via Runt-related transcription factor 2 (RUNX2)/core-binding factor subunit alpha-1 (CBF-alpha-1), Wingless-related integration site (Wnt)-3a/β-catenin signaling pathway and 11β Hydroxysteroid Dehydrogenase type 1.In this review, the authors provided a comprehensive summary of the literature related to association studies reported in humans as well work done until date to understand the potential cellular and molecular mechanisms that interplay between uric acid and bone metabolism." @default.
• W2899243374 created "2018-11-09" @default.
• W2899243374 creator A5019144480 @default.
• W2899243374 creator A5026864393 @default.
• W2899243374 creator A5033026219 @default.
• W2899243374 creator A5066685517 @default.
• W2899243374 date "2019-04-15" @default.
• W2899243374 modified "2023-10-16" @default.
• W2899243374 title "Review of the Literature Examining the Association of Serum Uric Acid with Osteoporosis and Mechanistic Insights into Its Effect on Bone Metabolism" @default.
• W2899243374 cites W1490030379 @default.
• W2899243374 cites W1524751812 @default.
• W2899243374 cites W1550524498 @default.
• W2899243374 cites W1599893459 @default.
• W2899243374 cites W1849034309 @default.
• W2899243374 cites W1872893906 @default.
• W2899243374 cites W1921722497 @default.
• W2899243374 cites W1932658676 @default.
• W2899243374 cites W1965524557 @default.
• W2899243374 cites W1966078997 @default.
• W2899243374 cites W1967357831 @default.
• W2899243374 cites W1969938702 @default.
• W2899243374 cites W1973370399 @default.
• W2899243374 cites W1975097555 @default.
• W2899243374 cites W1980762988 @default.
• W2899243374 cites W1984047972 @default.
• W2899243374 cites W1984486405 @default.
• W2899243374 cites W1985969855 @default.
• W2899243374 cites W1988721981 @default.
• W2899243374 cites W1991231767 @default.
• W2899243374 cites W1997812904 @default.
• W2899243374 cites W1999869967 @default.
• W2899243374 cites W2000166484 @default.
• W2899243374 cites W2002373438 @default.
• W2899243374 cites W2007261776 @default.
• W2899243374 cites W2007934093 @default.
• W2899243374 cites W2010393347 @default.
• W2899243374 cites W2012191117 @default.
• W2899243374 cites W2013015810 @default.
• W2899243374 cites W2015536677 @default.
• W2899243374 cites W2017418759 @default.
• W2899243374 cites W2018552952 @default.
• W2899243374 cites W2019196925 @default.
• W2899243374 cites W2020879886 @default.
• W2899243374 cites W2022570935 @default.
• W2899243374 cites W2025372788 @default.
• W2899243374 cites W2028472066 @default.
• W2899243374 cites W2031094699 @default.
• W2899243374 cites W2033831247 @default.
• W2899243374 cites W2039044326 @default.
• W2899243374 cites W2041425125 @default.
• W2899243374 cites W2044363593 @default.
• W2899243374 cites W2048553024 @default.
• W2899243374 cites W2048995421 @default.
• W2899243374 cites W2051041477 @default.
• W2899243374 cites W2051761022 @default.
• W2899243374 cites W2053516334 @default.
• W2899243374 cites W2056885783 @default.
• W2899243374 cites W2057373408 @default.
• W2899243374 cites W2067573703 @default.
• W2899243374 cites W2072473425 @default.
• W2899243374 cites W2073133712 @default.
• W2899243374 cites W2074206215 @default.
• W2899243374 cites W2077612318 @default.
• W2899243374 cites W2086101465 @default.
• W2899243374 cites W2087298134 @default.
• W2899243374 cites W2089158127 @default.
• W2899243374 cites W2101861123 @default.
• W2899243374 cites W2102154385 @default.
• W2899243374 cites W2102308076 @default.
• W2899243374 cites W2103913904 @default.
• W2899243374 cites W2106362601 @default.
• W2899243374 cites W2107177524 @default.
• W2899243374 cites W2107419879 @default.
• W2899243374 cites W2110768118 @default.
• W2899243374 cites W2113205707 @default.
• W2899243374 cites W2114651971 @default.
• W2899243374 cites W2117280294 @default.
• W2899243374 cites W2118044258 @default.
• W2899243374 cites W2118576106 @default.
• W2899243374 cites W2119962765 @default.
• W2899243374 cites W2120923270 @default.
• W2899243374 cites W2123346255 @default.
• W2899243374 cites W2128986278 @default.
• W2899243374 cites W2133331882 @default.
• W2899243374 cites W2133911598 @default.
• W2899243374 cites W2134315845 @default.
• W2899243374 cites W2137120147 @default.
• W2899243374 cites W2138223387 @default.
• W2899243374 cites W2144635750 @default.
• W2899243374 cites W2148265612 @default.
• W2899243374 cites W2149786401 @default.
• W2899243374 cites W2153101639 @default.
• W2899243374 cites W2158021558 @default.
• W2899243374 cites W2160507302 @default.
• W2899243374 cites W2162514978 @default.
• W2899243374 cites W2165201727 @default.
• W2899243374 cites W2171699178 @default.
• W2899243374 cites W2173192337 @default.

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