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- W2900187612 abstract "The Hedgehog (Hh) pathway is a signaling cascade that plays a crucial role in many fundamental processes, including embryonic development and tissue homeostasis. Moreover, emerging evidence has suggested that aberrant activation of Hh is associated with neoplastic transformations, malignant tumors, and drug resistance of a multitude of cancers. At the molecular level, it has been shown that Hh signaling drives the progression of cancers by regulating cancer cell proliferation, malignancy, metastasis, and the expansion of cancer stem cells (CSCs). Thus, a comprehensive understanding of Hh signaling during tumorigenesis and development of chemoresistance is necessary in order to identify potential therapeutic strategies to target various human cancers and their relapse. In this review, we discuss the molecular basis of the Hh signaling pathway and its abnormal activation in several types of human cancers. We also highlight the clinical development of Hh signaling inhibitors for cancer therapy as well as CSC-targeted therapy." @default.
- W2900187612 created "2018-11-16" @default.
- W2900187612 creator A5005523440 @default.
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- W2900187612 creator A5050866789 @default.
- W2900187612 creator A5079070649 @default.
- W2900187612 creator A5084941334 @default.
- W2900187612 date "2018-11-10" @default.
- W2900187612 modified "2023-10-14" @default.
- W2900187612 title "Hedgehog Signaling in Cancer: A Prospective Therapeutic Target for Eradicating Cancer Stem Cells" @default.
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