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- W2900203670 abstract "Omalizumab was the first, and for a long time the only available monoclonal antibody for the add-on treatment of severe allergic asthma. In particular, omalizumab selectively targets human immunoglobulin (Ig)E, forming small-size immune complexes that inhibit IgE binding to its high- and low-affinity receptors. Therefore, omalizumab effectively blunts the immune response in atopic asthmatic patients, thus significantly improving the control of asthma symptoms and successfully preventing disease exacerbations. These very positive effects of omalizumab make it possible to drastically decrease both referrals to the emergency room and hospitalizations for asthma exacerbations. Such important therapeutic actions of omalizumab have been documented by several randomized clinical trials, and especially by more than 10 years of real-life experience in daily clinical practice. Omalizumab can also interfere with airway remodelling by inhibiting the activation of IgE receptors located on structural cells such as bronchial epithelial cells and airway smooth muscle cells. Moreover, omalizumab is characterized by a very good safety and tolerability profile. Hence, omalizumab represents a valuable therapeutic option for the add-on biological treatment of severe allergic asthma." @default.
- W2900203670 created "2018-11-16" @default.
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- W2900203670 date "2018-01-01" @default.
- W2900203670 modified "2023-10-14" @default.
- W2900203670 title "Omalizumab, the first available antibody for biological treatment of severe asthma: more than a decade of real-life effectiveness" @default.
- W2900203670 cites W1494211513 @default.
- W2900203670 cites W1541345074 @default.
- W2900203670 cites W1547456763 @default.
- W2900203670 cites W158821231 @default.
- W2900203670 cites W1605522372 @default.
- W2900203670 cites W1655614253 @default.
- W2900203670 cites W1676650238 @default.
- W2900203670 cites W1835232554 @default.
- W2900203670 cites W1876031798 @default.
- W2900203670 cites W1887965535 @default.
- W2900203670 cites W1949221250 @default.
- W2900203670 cites W1967215794 @default.
- W2900203670 cites W1967776297 @default.
- W2900203670 cites W1970594645 @default.
- W2900203670 cites W1975696541 @default.
- W2900203670 cites W1977639139 @default.
- W2900203670 cites W1982141273 @default.
- W2900203670 cites W1985017750 @default.
- W2900203670 cites W1986966401 @default.
- W2900203670 cites W1987444459 @default.
- W2900203670 cites W1988223366 @default.
- W2900203670 cites W1990367169 @default.
- W2900203670 cites W1993931609 @default.
- W2900203670 cites W1994268130 @default.
- W2900203670 cites W1995682991 @default.
- W2900203670 cites W2000167866 @default.
- W2900203670 cites W2002338137 @default.
- W2900203670 cites W2004145744 @default.
- W2900203670 cites W2005749129 @default.
- W2900203670 cites W2008669313 @default.
- W2900203670 cites W2008931469 @default.
- W2900203670 cites W2009933260 @default.
- W2900203670 cites W2010946738 @default.
- W2900203670 cites W2015082452 @default.
- W2900203670 cites W2015409726 @default.
- W2900203670 cites W2016429975 @default.
- W2900203670 cites W2017754261 @default.
- W2900203670 cites W2017866305 @default.
- W2900203670 cites W2025232743 @default.
- W2900203670 cites W2027541305 @default.
- W2900203670 cites W2029319906 @default.
- W2900203670 cites W2029587541 @default.
- W2900203670 cites W2030415090 @default.
- W2900203670 cites W2031029516 @default.
- W2900203670 cites W2031117019 @default.
- W2900203670 cites W2031161541 @default.
- W2900203670 cites W2033075230 @default.
- W2900203670 cites W2034349740 @default.
- W2900203670 cites W2036782042 @default.
- W2900203670 cites W2037071616 @default.
- W2900203670 cites W2038883847 @default.
- W2900203670 cites W2040174668 @default.
- W2900203670 cites W2040438448 @default.
- W2900203670 cites W2040640809 @default.
- W2900203670 cites W2042287841 @default.
- W2900203670 cites W2044332962 @default.
- W2900203670 cites W2047787274 @default.
- W2900203670 cites W2051331973 @default.
- W2900203670 cites W2054071581 @default.
- W2900203670 cites W2055192969 @default.
- W2900203670 cites W2060015303 @default.
- W2900203670 cites W2060636831 @default.
- W2900203670 cites W2061775758 @default.
- W2900203670 cites W2062888033 @default.
- W2900203670 cites W2064671047 @default.
- W2900203670 cites W2065071227 @default.
- W2900203670 cites W2066531673 @default.
- W2900203670 cites W2070201691 @default.
- W2900203670 cites W2074677758 @default.
- W2900203670 cites W2079882627 @default.
- W2900203670 cites W2085990242 @default.
- W2900203670 cites W2086714187 @default.
- W2900203670 cites W2089108474 @default.
- W2900203670 cites W2090011123 @default.
- W2900203670 cites W2091327712 @default.
- W2900203670 cites W2097981132 @default.
- W2900203670 cites W2099211356 @default.
- W2900203670 cites W2099930038 @default.
- W2900203670 cites W2103541662 @default.
- W2900203670 cites W2108850242 @default.
- W2900203670 cites W2110052844 @default.
- W2900203670 cites W2110500887 @default.
- W2900203670 cites W2110842129 @default.
- W2900203670 cites W2112849484 @default.
- W2900203670 cites W2118347957 @default.
- W2900203670 cites W2120901603 @default.
- W2900203670 cites W2121954044 @default.