FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2909403202> ?p ?o ?g. }

• W2909403202 endingPage "510" @default.
• W2909403202 startingPage "504" @default.
• W2909403202 abstract "Recent findings have shown that Farnesoid X Receptor (FXR) antagonists might be useful in the treatment of cholestasis and related metabolic disorders. In this paper, we report the discovery of a new chemotype of FXR antagonists featured by a 3,5-disubstituted oxadiazole core. In total, 35 new derivatives were designed and synthesized, and notably, compounds 3f and 13, containing a piperidine ring, displayed the best antagonistic activity against FXR with promising cellular potency (IC50 = 0.58 ± 0.27 and 0.127 ± 0.02 μM, respectively). The excellent pharmacokinetic properties make compound 3f the most promising lead identified in this study." @default.
• W2909403202 created "2019-01-25" @default.
• W2909403202 creator A5026034661 @default.
• W2909403202 creator A5037262184 @default.
• W2909403202 creator A5037630349 @default.
• W2909403202 creator A5038809461 @default.
• W2909403202 creator A5057377004 @default.
• W2909403202 creator A5057417175 @default.
• W2909403202 creator A5057720130 @default.
• W2909403202 creator A5062272837 @default.
• W2909403202 creator A5065995030 @default.
• W2909403202 creator A5072254927 @default.
• W2909403202 creator A5075654355 @default.
• W2909403202 creator A5087263227 @default.
• W2909403202 date "2019-01-10" @default.
• W2909403202 modified "2023-10-18" @default.
• W2909403202 title "Investigation around the Oxadiazole Core in the Discovery of a New Chemotype of Potent and Selective FXR Antagonists" @default.
• W2909403202 cites W1964777932 @default.
• W2909403202 cites W1976621716 @default.
• W2909403202 cites W1997197238 @default.
• W2909403202 cites W2001058921 @default.
• W2909403202 cites W2022401833 @default.
• W2909403202 cites W2042406625 @default.
• W2909403202 cites W2045223517 @default.
• W2909403202 cites W2052667160 @default.
• W2909403202 cites W2053581007 @default.
• W2909403202 cites W2093406272 @default.
• W2909403202 cites W2095520328 @default.
• W2909403202 cites W2101738855 @default.
• W2909403202 cites W2102459969 @default.
• W2909403202 cites W2111160264 @default.
• W2909403202 cites W2171398834 @default.
• W2909403202 cites W2176087009 @default.
• W2909403202 cites W2282020797 @default.
• W2909403202 cites W2519008943 @default.
• W2909403202 cites W2741344135 @default.
• W2909403202 cites W2781916466 @default.
• W2909403202 cites W2799477370 @default.
• W2909403202 cites W2869244062 @default.
• W2909403202 doi "https://doi.org/10.1021/acsmedchemlett.8b00534" @default.
• W2909403202 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6466555" @default.
• W2909403202 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30996787" @default.
• W2909403202 hasPublicationYear "2019" @default.
• W2909403202 type Work @default.
• W2909403202 sameAs 2909403202 @default.
• W2909403202 citedByCount "24" @default.
• W2909403202 countsByYear W29094032022019 @default.
• W2909403202 countsByYear W29094032022020 @default.
• W2909403202 countsByYear W29094032022021 @default.
• W2909403202 countsByYear W29094032022022 @default.
• W2909403202 countsByYear W29094032022023 @default.
• W2909403202 crossrefType "journal-article" @default.
• W2909403202 hasAuthorship W2909403202A5026034661 @default.
• W2909403202 hasAuthorship W2909403202A5037262184 @default.
• W2909403202 hasAuthorship W2909403202A5037630349 @default.
• W2909403202 hasAuthorship W2909403202A5038809461 @default.
• W2909403202 hasAuthorship W2909403202A5057377004 @default.
• W2909403202 hasAuthorship W2909403202A5057417175 @default.
• W2909403202 hasAuthorship W2909403202A5057720130 @default.
• W2909403202 hasAuthorship W2909403202A5062272837 @default.
• W2909403202 hasAuthorship W2909403202A5065995030 @default.
• W2909403202 hasAuthorship W2909403202A5072254927 @default.
• W2909403202 hasAuthorship W2909403202A5075654355 @default.
• W2909403202 hasAuthorship W2909403202A5087263227 @default.
• W2909403202 hasBestOaLocation W29094032022 @default.
• W2909403202 hasConcept C104317684 @default.
• W2909403202 hasConcept C112705442 @default.
• W2909403202 hasConcept C153784791 @default.
• W2909403202 hasConcept C178790620 @default.
• W2909403202 hasConcept C185592680 @default.
• W2909403202 hasConcept C202751555 @default.
• W2909403202 hasConcept C203862802 @default.
• W2909403202 hasConcept C21951064 @default.
• W2909403202 hasConcept C2777278459 @default.
• W2909403202 hasConcept C2777752497 @default.
• W2909403202 hasConcept C2779448499 @default.
• W2909403202 hasConcept C2781462491 @default.
• W2909403202 hasConcept C43617362 @default.
• W2909403202 hasConcept C55493867 @default.
• W2909403202 hasConcept C57992300 @default.
• W2909403202 hasConcept C63932345 @default.
• W2909403202 hasConcept C71240020 @default.
• W2909403202 hasConcept C71924100 @default.
• W2909403202 hasConcept C74187038 @default.
• W2909403202 hasConcept C86339819 @default.
• W2909403202 hasConcept C98274493 @default.
• W2909403202 hasConceptScore W2909403202C104317684 @default.
• W2909403202 hasConceptScore W2909403202C112705442 @default.
• W2909403202 hasConceptScore W2909403202C153784791 @default.
• W2909403202 hasConceptScore W2909403202C178790620 @default.
• W2909403202 hasConceptScore W2909403202C185592680 @default.
• W2909403202 hasConceptScore W2909403202C202751555 @default.
• W2909403202 hasConceptScore W2909403202C203862802 @default.
• W2909403202 hasConceptScore W2909403202C21951064 @default.
• W2909403202 hasConceptScore W2909403202C2777278459 @default.
• W2909403202 hasConceptScore W2909403202C2777752497 @default.
• W2909403202 hasConceptScore W2909403202C2779448499 @default.
• W2909403202 hasConceptScore W2909403202C2781462491 @default.

• next