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- W2910299820 abstract "There is a growing interest in the role of lipid membrane composition in the physiology and adaptation of bacteria. We demonstrate that a reduction in the anionic phospholipid cardiolipin impairs biofilm formation in Escherichia coli cells. Depleting cardiolipin reduced protein translocation across the inner membrane and activated the Rcs envelope stress response. Consequently, cardiolipin depletion produced cells lacking assembled flagella, which impacted their ability to attach to surfaces and seed the earliest stage in biofilm formation. This study provides empirical evidence for the role of anionic phospholipid homeostasis in protein translocation and its effect on biofilm development and highlights modulation of the membrane composition as a potential method of altering bacterial phenotypes related to adaptation and survival." @default.
- W2910299820 created "2019-01-25" @default.
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- W2910299820 creator A5036170326 @default.
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- W2910299820 date "2019-05-01" @default.
- W2910299820 modified "2023-10-15" @default.
- W2910299820 title "Rcs Phosphorelay Activation in Cardiolipin-Deficient Escherichia coli Reduces Biofilm Formation" @default.
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- W2910299820 doi "https://doi.org/10.1128/jb.00804-18" @default.
- W2910299820 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6456859" @default.
- W2910299820 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30782633" @default.
- W2910299820 hasPublicationYear "2019" @default.
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