Matches in SemOpenAlex for { <https://semopenalex.org/work/W2910366994> ?p ?o ?g. }
- W2910366994 abstract "ABSTRACT Over the past decade, new methods and procedures have been developed to generate genetically engineered mouse models of human disease. This At a Glance article highlights several recent technical advances in mouse genome manipulation that have transformed our ability to manipulate and study gene expression in the mouse. We discuss how conventional gene targeting by homologous recombination in embryonic stem cells has given way to more refined methods that enable allele-specific manipulation in zygotes. We also highlight advances in the use of programmable endonucleases that have greatly increased the feasibility and ease of editing the mouse genome. Together, these and other technologies provide researchers with the molecular tools to functionally annotate the mouse genome with greater fidelity and specificity, as well as to generate new mouse models using faster, simpler and less costly techniques." @default.
- W2910366994 created "2019-01-25" @default.
- W2910366994 creator A5059847851 @default.
- W2910366994 creator A5072324344 @default.
- W2910366994 date "2019-01-01" @default.
- W2910366994 modified "2023-10-12" @default.
- W2910366994 title "Generating mouse models for biomedical research: technological advances" @default.
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