FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912117958> ?p ?o ?g. }

• W2912117958 endingPage "629" @default.
• W2912117958 startingPage "621" @default.
• W2912117958 abstract "Abstract Preclinical data show that intravesical instillation of Ty21a/Vivotif, a commercial vaccine against typhoid fever, is an effective alternative option to standard Bacillus Calmette–Guérin (BCG) immunotherapy for non–muscle-invasive bladder cancer (NMIBC). Here, we characterized the inflammatory effects of Ty21a on the bladder and investigated the immune mechanisms underlying tumor regression toward the use of this bacterial vaccine in NMIBC patients. MB49 bladder tumor–bearing mice had significantly improved survival after intravesical instillations of Ty21a doses of 106 to 108 colony-forming units. By IHC and morphology, both BCG and Ty21a instillations were associated with bladder inflammation, which was decreased with the use of low, but effective doses of Ty21a. Flow-cytometry analysis showed a significant infiltration of T cells, natural killer (NK) cells, and myeloid cells, compared with controls, after a single dose of Ty21a, whereas this was only observed after multiple doses of BCG. The induced myeloid cells were predominantly neutrophils and Ly6C+CD103+ dendritic cells (DC), the latter being significantly more numerous after instillation of Ty21a than BCG. Ex vivo infection of human leukocytes with Ty21a, but not BCG, similarly significantly increased DC frequency. CD4+ and CD8+ T cells, but not NK cells nor neutrophils, were required for effective bladder tumor regression upon Ty21a treatment. Thus, the generation of antitumor adaptive immunity was identified as a key process underlying Ty21a-mediated treatment efficacy. Altogether, these results demonstrate mechanisms behind intravesical Ty21a therapy and suggest its potential as a safe and effective treatment for NMIBC patients." @default.
• W2912117958 created "2019-02-21" @default.
• W2912117958 creator A5010836672 @default.
• W2912117958 creator A5010884210 @default.
• W2912117958 creator A5015606455 @default.
• W2912117958 creator A5017203921 @default.
• W2912117958 creator A5026829327 @default.
• W2912117958 creator A5030128430 @default.
• W2912117958 creator A5033408456 @default.
• W2912117958 creator A5033918140 @default.
• W2912117958 creator A5043727336 @default.
• W2912117958 creator A5045427753 @default.
• W2912117958 creator A5088567269 @default.
• W2912117958 date "2019-04-01" @default.
• W2912117958 modified "2023-09-24" @default.
• W2912117958 title "Intravesical Ty21a Vaccine Promotes Dendritic Cells and T Cell–Mediated Tumor Regression in the MB49 Bladder Cancer Model" @default.
• W2912117958 cites W1199133249 @default.
• W2912117958 cites W1502222950 @default.
• W2912117958 cites W1578051988 @default.
• W2912117958 cites W1966900148 @default.
• W2912117958 cites W1987591286 @default.
• W2912117958 cites W2011660410 @default.
• W2912117958 cites W2025682062 @default.
• W2912117958 cites W2041308303 @default.
• W2912117958 cites W2041437825 @default.
• W2912117958 cites W2051139585 @default.
• W2912117958 cites W2051227478 @default.
• W2912117958 cites W2056628849 @default.
• W2912117958 cites W2064352891 @default.
• W2912117958 cites W2079709122 @default.
• W2912117958 cites W2087506817 @default.
• W2912117958 cites W2108459650 @default.
• W2912117958 cites W2124573253 @default.
• W2912117958 cites W2149886962 @default.
• W2912117958 cites W2151781453 @default.
• W2912117958 cites W2165948908 @default.
• W2912117958 cites W2168083201 @default.
• W2912117958 cites W2341604280 @default.
• W2912117958 cites W2545733225 @default.
• W2912117958 cites W2560351339 @default.
• W2912117958 cites W2604792316 @default.
• W2912117958 cites W2647469809 @default.
• W2912117958 cites W2777096226 @default.
• W2912117958 cites W2783617985 @default.
• W2912117958 cites W2916183155 @default.
• W2912117958 doi "https://doi.org/10.1158/2326-6066.cir-18-0671" @default.
• W2912117958 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30696629" @default.
• W2912117958 hasPublicationYear "2019" @default.
• W2912117958 type Work @default.
• W2912117958 sameAs 2912117958 @default.
• W2912117958 citedByCount "17" @default.
• W2912117958 countsByYear W29121179582020 @default.
• W2912117958 countsByYear W29121179582021 @default.
• W2912117958 countsByYear W29121179582022 @default.
• W2912117958 crossrefType "journal-article" @default.
• W2912117958 hasAuthorship W2912117958A5010836672 @default.
• W2912117958 hasAuthorship W2912117958A5010884210 @default.
• W2912117958 hasAuthorship W2912117958A5015606455 @default.
• W2912117958 hasAuthorship W2912117958A5017203921 @default.
• W2912117958 hasAuthorship W2912117958A5026829327 @default.
• W2912117958 hasAuthorship W2912117958A5030128430 @default.
• W2912117958 hasAuthorship W2912117958A5033408456 @default.
• W2912117958 hasAuthorship W2912117958A5033918140 @default.
• W2912117958 hasAuthorship W2912117958A5043727336 @default.
• W2912117958 hasAuthorship W2912117958A5045427753 @default.
• W2912117958 hasAuthorship W2912117958A5088567269 @default.
• W2912117958 hasBestOaLocation W29121179581 @default.
• W2912117958 hasConcept C121608353 @default.
• W2912117958 hasConcept C126322002 @default.
• W2912117958 hasConcept C154317977 @default.
• W2912117958 hasConcept C167672396 @default.
• W2912117958 hasConcept C202751555 @default.
• W2912117958 hasConcept C203014093 @default.
• W2912117958 hasConcept C2777701055 @default.
• W2912117958 hasConcept C2780352672 @default.
• W2912117958 hasConcept C502942594 @default.
• W2912117958 hasConcept C55493867 @default.
• W2912117958 hasConcept C71924100 @default.
• W2912117958 hasConcept C86803240 @default.
• W2912117958 hasConcept C8891405 @default.
• W2912117958 hasConceptScore W2912117958C121608353 @default.
• W2912117958 hasConceptScore W2912117958C126322002 @default.
• W2912117958 hasConceptScore W2912117958C154317977 @default.
• W2912117958 hasConceptScore W2912117958C167672396 @default.
• W2912117958 hasConceptScore W2912117958C202751555 @default.
• W2912117958 hasConceptScore W2912117958C203014093 @default.
• W2912117958 hasConceptScore W2912117958C2777701055 @default.
• W2912117958 hasConceptScore W2912117958C2780352672 @default.
• W2912117958 hasConceptScore W2912117958C502942594 @default.
• W2912117958 hasConceptScore W2912117958C55493867 @default.
• W2912117958 hasConceptScore W2912117958C71924100 @default.
• W2912117958 hasConceptScore W2912117958C86803240 @default.
• W2912117958 hasConceptScore W2912117958C8891405 @default.
• W2912117958 hasIssue "4" @default.
• W2912117958 hasLocation W29121179581 @default.
• W2912117958 hasLocation W29121179582 @default.
• W2912117958 hasLocation W29121179583 @default.
• W2912117958 hasLocation W29121179584 @default.

• next