Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912131337> ?p ?o ?g. }
- W2912131337 endingPage "e1007561" @default.
- W2912131337 startingPage "e1007561" @default.
- W2912131337 abstract "Paramyxoviruses can establish persistent infections both in vitro and in vivo, some of which lead to chronic disease. However, little is known about the molecular events that contribute to the establishment of persistent infections by RNA viruses. Using parainfluenza virus type 5 (PIV5) as a model we show that phosphorylation of the P protein, which is a key component of the viral RNA polymerase complex, determines whether or not viral transcription and replication becomes repressed at late times after infection. If the virus becomes repressed, persistence is established, but if not, the infected cells die. We found that single amino acid changes at various positions within the P protein switched the infection phenotype from lytic to persistent. Lytic variants replicated to higher titres in mice than persistent variants and caused greater infiltration of immune cells into infected lungs but were cleared more rapidly. We propose that during the acute phases of viral infection in vivo, lytic variants of PIV5 will be selected but, as the adaptive immune response develops, variants in which viral replication can be repressed will be selected, leading to the establishment of prolonged, persistent infections. We suggest that similar selection processes may operate for other RNA viruses." @default.
- W2912131337 created "2019-02-21" @default.
- W2912131337 creator A5013025036 @default.
- W2912131337 creator A5017205113 @default.
- W2912131337 creator A5028387451 @default.
- W2912131337 creator A5029522995 @default.
- W2912131337 creator A5039230558 @default.
- W2912131337 creator A5045678778 @default.
- W2912131337 creator A5047283974 @default.
- W2912131337 creator A5056013751 @default.
- W2912131337 creator A5061748052 @default.
- W2912131337 creator A5062361314 @default.
- W2912131337 creator A5073128447 @default.
- W2912131337 creator A5076915144 @default.
- W2912131337 date "2019-02-11" @default.
- W2912131337 modified "2023-09-26" @default.
- W2912131337 title "The switch between acute and persistent paramyxovirus infection caused by single amino acid substitutions in the RNA polymerase P subunit" @default.
- W2912131337 cites W1120694713 @default.
- W2912131337 cites W1556627846 @default.
- W2912131337 cites W1969689219 @default.
- W2912131337 cites W1973413494 @default.
- W2912131337 cites W1982448036 @default.
- W2912131337 cites W1997432096 @default.
- W2912131337 cites W2003574450 @default.
- W2912131337 cites W2008573799 @default.
- W2912131337 cites W2014212971 @default.
- W2912131337 cites W2016781165 @default.
- W2912131337 cites W2019668119 @default.
- W2912131337 cites W2020748617 @default.
- W2912131337 cites W2035909170 @default.
- W2912131337 cites W2037395873 @default.
- W2912131337 cites W2037431531 @default.
- W2912131337 cites W2039852963 @default.
- W2912131337 cites W2040371676 @default.
- W2912131337 cites W2046886534 @default.
- W2912131337 cites W2060380182 @default.
- W2912131337 cites W2073918065 @default.
- W2912131337 cites W2076174740 @default.
- W2912131337 cites W2090061143 @default.
- W2912131337 cites W2093096499 @default.
- W2912131337 cites W2096695176 @default.
- W2912131337 cites W2098918789 @default.
- W2912131337 cites W2101667213 @default.
- W2912131337 cites W2113975414 @default.
- W2912131337 cites W2114168749 @default.
- W2912131337 cites W2117495451 @default.
- W2912131337 cites W2123163123 @default.
- W2912131337 cites W2124913228 @default.
- W2912131337 cites W2131777988 @default.
- W2912131337 cites W2135453176 @default.
- W2912131337 cites W2138665029 @default.
- W2912131337 cites W2150316968 @default.
- W2912131337 cites W2151001361 @default.
- W2912131337 cites W2164891125 @default.
- W2912131337 cites W2169219347 @default.
- W2912131337 cites W2171543911 @default.
- W2912131337 cites W2171685767 @default.
- W2912131337 cites W2174701321 @default.
- W2912131337 cites W2300676094 @default.
- W2912131337 cites W2408165254 @default.
- W2912131337 cites W2475764149 @default.
- W2912131337 cites W2582812171 @default.
- W2912131337 cites W2595587791 @default.
- W2912131337 cites W2618247254 @default.
- W2912131337 cites W2787937367 @default.
- W2912131337 cites W2793807514 @default.
- W2912131337 cites W2808070694 @default.
- W2912131337 cites W4206712614 @default.
- W2912131337 cites W2006326161 @default.
- W2912131337 doi "https://doi.org/10.1371/journal.ppat.1007561" @default.
- W2912131337 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6386407" @default.
- W2912131337 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30742688" @default.
- W2912131337 hasPublicationYear "2019" @default.
- W2912131337 type Work @default.
- W2912131337 sameAs 2912131337 @default.
- W2912131337 citedByCount "19" @default.
- W2912131337 countsByYear W29121313372019 @default.
- W2912131337 countsByYear W29121313372020 @default.
- W2912131337 countsByYear W29121313372021 @default.
- W2912131337 countsByYear W29121313372022 @default.
- W2912131337 crossrefType "journal-article" @default.
- W2912131337 hasAuthorship W2912131337A5013025036 @default.
- W2912131337 hasAuthorship W2912131337A5017205113 @default.
- W2912131337 hasAuthorship W2912131337A5028387451 @default.
- W2912131337 hasAuthorship W2912131337A5029522995 @default.
- W2912131337 hasAuthorship W2912131337A5039230558 @default.
- W2912131337 hasAuthorship W2912131337A5045678778 @default.
- W2912131337 hasAuthorship W2912131337A5047283974 @default.
- W2912131337 hasAuthorship W2912131337A5056013751 @default.
- W2912131337 hasAuthorship W2912131337A5061748052 @default.
- W2912131337 hasAuthorship W2912131337A5062361314 @default.
- W2912131337 hasAuthorship W2912131337A5073128447 @default.
- W2912131337 hasAuthorship W2912131337A5076915144 @default.
- W2912131337 hasBestOaLocation W29121313371 @default.
- W2912131337 hasConcept C104292427 @default.
- W2912131337 hasConcept C104317684 @default.
- W2912131337 hasConcept C153911025 @default.
- W2912131337 hasConcept C159047783 @default.