FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912146827> ?p ?o ?g. }

• W2912146827 endingPage "145" @default.
• W2912146827 startingPage "139" @default.
• W2912146827 abstract "Objective The aim of this study was to evaluate the immunostaining of inflammatory, apoptotic, and bone markers, as well as Toll-like-receptors (TLRs) 2 and 4 in the dental pulp in rats treated with zoledronic acid (ZA). Study Design We administered 4 intravascular infusions of saline (control group) or 0.20 mg.kg−1 ZA in Wistar rats (n = 6/group). After 70 days, the 3 rights molars (n = 18/group) were microscopically evaluated (presence of ectasic/dilated blood vessels and inflammatory cells). Immunohistochemistry was performed for tartrate resistant acid phosphatase 5 (TRAP; cell counting), cyclooxygenase-2 (COX-2), interleukin-6 (IL-6), TLR2, TLR4, receptor activator of nuclear kappa B ligand (RANKL), osteoprotegerin (OPG), and caspase-3 (scored 0–3 in odontoblast and nonodontoblast dental pulp cells). Mann-Whitney and Fisher's exact tests and Spearman's correlation were used (GraphPad Prism 5.0). Results There was no alteration in ectasic/dilated blood vessels (P = .101) or inflammatory cells (P = .500), but the number of TRAP-positive cells was reduced in the ZA-group (P = .027). In ZA-group odontoblasts, immunostaining for COX-2 (P = .044), TLR4 (P = .003), OPG (P = .035) and caspase-3 (P = .039) increased, and that for RANKL (P = 0.045) decreased. In nonodontoblast dental pulp cells, RANKL immunostaining decreased (P = .009). In the ZA group, the RANKL/OPG ratio decreased in odontoblast (P = .022) and nonodontoblast dental pulp cells (P = .007). IL-6 did not differ between the groups. Conclusions ZA increases the expression levels of inflammatory, apoptotic markers, and TLR4 and alters bone makers in the dental pulp of rats. The aim of this study was to evaluate the immunostaining of inflammatory, apoptotic, and bone markers, as well as Toll-like-receptors (TLRs) 2 and 4 in the dental pulp in rats treated with zoledronic acid (ZA). We administered 4 intravascular infusions of saline (control group) or 0.20 mg.kg−1 ZA in Wistar rats (n = 6/group). After 70 days, the 3 rights molars (n = 18/group) were microscopically evaluated (presence of ectasic/dilated blood vessels and inflammatory cells). Immunohistochemistry was performed for tartrate resistant acid phosphatase 5 (TRAP; cell counting), cyclooxygenase-2 (COX-2), interleukin-6 (IL-6), TLR2, TLR4, receptor activator of nuclear kappa B ligand (RANKL), osteoprotegerin (OPG), and caspase-3 (scored 0–3 in odontoblast and nonodontoblast dental pulp cells). Mann-Whitney and Fisher's exact tests and Spearman's correlation were used (GraphPad Prism 5.0). There was no alteration in ectasic/dilated blood vessels (P = .101) or inflammatory cells (P = .500), but the number of TRAP-positive cells was reduced in the ZA-group (P = .027). In ZA-group odontoblasts, immunostaining for COX-2 (P = .044), TLR4 (P = .003), OPG (P = .035) and caspase-3 (P = .039) increased, and that for RANKL (P = 0.045) decreased. In nonodontoblast dental pulp cells, RANKL immunostaining decreased (P = .009). In the ZA group, the RANKL/OPG ratio decreased in odontoblast (P = .022) and nonodontoblast dental pulp cells (P = .007). IL-6 did not differ between the groups. ZA increases the expression levels of inflammatory, apoptotic markers, and TLR4 and alters bone makers in the dental pulp of rats." @default.
• W2912146827 created "2019-02-21" @default.
• W2912146827 creator A5001835137 @default.
• W2912146827 creator A5006822208 @default.
• W2912146827 creator A5012881347 @default.
• W2912146827 creator A5014569708 @default.
• W2912146827 creator A5030861045 @default.
• W2912146827 creator A5037951031 @default.
• W2912146827 creator A5056269947 @default.
• W2912146827 creator A5081188886 @default.
• W2912146827 date "2019-08-01" @default.
• W2912146827 modified "2023-10-17" @default.
• W2912146827 title "Chronic treatment with zoledronic acid alters the expression levels of inflammatory, bone, and apoptotic markers and Toll-like receptors 2 and 4 in rat dental pulp" @default.
• W2912146827 cites W1606795972 @default.
• W2912146827 cites W1881952764 @default.
• W2912146827 cites W1888974209 @default.
• W2912146827 cites W1914449464 @default.
• W2912146827 cites W1918195936 @default.
• W2912146827 cites W1970506687 @default.
• W2912146827 cites W1975295083 @default.
• W2912146827 cites W1975953388 @default.
• W2912146827 cites W1979062280 @default.
• W2912146827 cites W1986556213 @default.
• W2912146827 cites W2032158851 @default.
• W2912146827 cites W2033872292 @default.
• W2912146827 cites W2057715814 @default.
• W2912146827 cites W2059013457 @default.
• W2912146827 cites W2064800356 @default.
• W2912146827 cites W2065343929 @default.
• W2912146827 cites W2072686928 @default.
• W2912146827 cites W2079908422 @default.
• W2912146827 cites W2098700462 @default.
• W2912146827 cites W2116095052 @default.
• W2912146827 cites W2117524665 @default.
• W2912146827 cites W2124260947 @default.
• W2912146827 cites W2130964548 @default.
• W2912146827 cites W2139357871 @default.
• W2912146827 cites W2149827038 @default.
• W2912146827 cites W2315155322 @default.
• W2912146827 cites W2474413674 @default.
• W2912146827 cites W2563372119 @default.
• W2912146827 cites W2595907426 @default.
• W2912146827 cites W2729168157 @default.
• W2912146827 cites W2740451320 @default.
• W2912146827 cites W2744529340 @default.
• W2912146827 cites W2757274710 @default.
• W2912146827 doi "https://doi.org/10.1016/j.oooo.2019.01.069" @default.
• W2912146827 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30935783" @default.
• W2912146827 hasPublicationYear "2019" @default.
• W2912146827 type Work @default.
• W2912146827 sameAs 2912146827 @default.
• W2912146827 citedByCount "5" @default.
• W2912146827 countsByYear W29121468272019 @default.
• W2912146827 countsByYear W29121468272020 @default.
• W2912146827 countsByYear W29121468272021 @default.
• W2912146827 countsByYear W29121468272023 @default.
• W2912146827 crossrefType "journal-article" @default.
• W2912146827 hasAuthorship W2912146827A5001835137 @default.
• W2912146827 hasAuthorship W2912146827A5006822208 @default.
• W2912146827 hasAuthorship W2912146827A5012881347 @default.
• W2912146827 hasAuthorship W2912146827A5014569708 @default.
• W2912146827 hasAuthorship W2912146827A5030861045 @default.
• W2912146827 hasAuthorship W2912146827A5037951031 @default.
• W2912146827 hasAuthorship W2912146827A5056269947 @default.
• W2912146827 hasAuthorship W2912146827A5081188886 @default.
• W2912146827 hasConcept C126322002 @default.
• W2912146827 hasConcept C134018914 @default.
• W2912146827 hasConcept C142724271 @default.
• W2912146827 hasConcept C164027704 @default.
• W2912146827 hasConcept C170493617 @default.
• W2912146827 hasConcept C185592680 @default.
• W2912146827 hasConcept C188442228 @default.
• W2912146827 hasConcept C190283241 @default.
• W2912146827 hasConcept C204232928 @default.
• W2912146827 hasConcept C2776070231 @default.
• W2912146827 hasConcept C2776914184 @default.
• W2912146827 hasConcept C2779428903 @default.
• W2912146827 hasConcept C2780426850 @default.
• W2912146827 hasConcept C2781236682 @default.
• W2912146827 hasConcept C4224716 @default.
• W2912146827 hasConcept C55493867 @default.
• W2912146827 hasConcept C71924100 @default.
• W2912146827 hasConcept C88045685 @default.
• W2912146827 hasConceptScore W2912146827C126322002 @default.
• W2912146827 hasConceptScore W2912146827C134018914 @default.
• W2912146827 hasConceptScore W2912146827C142724271 @default.
• W2912146827 hasConceptScore W2912146827C164027704 @default.
• W2912146827 hasConceptScore W2912146827C170493617 @default.
• W2912146827 hasConceptScore W2912146827C185592680 @default.
• W2912146827 hasConceptScore W2912146827C188442228 @default.
• W2912146827 hasConceptScore W2912146827C190283241 @default.
• W2912146827 hasConceptScore W2912146827C204232928 @default.
• W2912146827 hasConceptScore W2912146827C2776070231 @default.
• W2912146827 hasConceptScore W2912146827C2776914184 @default.
• W2912146827 hasConceptScore W2912146827C2779428903 @default.
• W2912146827 hasConceptScore W2912146827C2780426850 @default.
• W2912146827 hasConceptScore W2912146827C2781236682 @default.
• W2912146827 hasConceptScore W2912146827C4224716 @default.

• next