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- W2912321337 abstract "Abstract N -acetylcysteine (NAC) is widely used as a mucolytic agent and as an antidote to paracetamol overdose. NAC serves as a precursor of cysteine and stimulates the synthesis of glutathione in neural cells. Suppressing oxidative stress in the retina may be an effective therapeutic strategy for glaucoma, a chronic neurodegenerative disease of the retinal ganglion cells (RGCs) and optic nerves. Here we examined the therapeutic potential of NAC in two mouse models of normal tension glaucoma, in which excitatory amino-acid carrier 1 ( EAAC1 ) or glutamate/aspartate transporter ( GLAST ) gene was deleted. EAAC1 is expressed in retinal neurons including RGCs, whereas GLAST is mainly expressed in Müller glial cells. Intraperitoneal administration of NAC prevented RGC degeneration and visual impairment in EAAC1-deficient (knockout; KO) mice, but not in GLAST KO mice. In EAAC1 KO mice, oxidative stress and autophagy were suppressed with increased glutathione levels by NAC treatment. Our findings suggest a possibility that systemic administration of NAC may be available for some types of glaucoma patients." @default.
- W2912321337 created "2019-02-21" @default.
- W2912321337 creator A5024953854 @default.
- W2912321337 creator A5032304374 @default.
- W2912321337 creator A5045694734 @default.
- W2912321337 creator A5052128175 @default.
- W2912321337 creator A5059221779 @default.
- W2912321337 creator A5071606551 @default.
- W2912321337 creator A5074292636 @default.
- W2912321337 creator A5078368687 @default.
- W2912321337 date "2019-01-28" @default.
- W2912321337 modified "2023-10-17" @default.
- W2912321337 title "Differential effects of N-acetylcysteine on retinal degeneration in two mouse models of normal tension glaucoma" @default.
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- W2912321337 doi "https://doi.org/10.1038/s41419-019-1365-z" @default.