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- W2912459817 abstract "From an abstract, informational perspective, protein domains appear analogous to words in natural languages in which the rules of word association are dictated by linguistic rules, or grammar. Such rules exist for protein domains as well, because only a small fraction of all possible domain combinations is viable in evolution. We employ a popular linguistic technique, n -gram analysis, to probe the “proteome grammar”—that is, the rules of association of domains that generate various domain architectures of proteins. Comparison of the complexity measures of “protein languages” in major branches of life shows that the relative entropy difference (information gain) between the observed domain architectures and random domain combinations is highly conserved in evolution and is close to being a universal constant, at ∼1.2 bits. Substantial deviations from this constant are observed in only two major groups of organisms: a subset of Archaea that appears to be cells simplified to the limit, and animals that display extreme complexity. We also identify the n- grams that represent signatures of the major branches of cellular life. The results of this analysis bolster the analogy between genomes and natural language and show that a “quasi-universal grammar” underlies the evolution of domain architectures in all divisions of cellular life. The nearly universal value of information gain by the domain architectures could reflect the minimum complexity of signal processing that is required to maintain a functioning cell." @default.
- W2912459817 created "2019-02-21" @default.
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- W2912459817 date "2019-02-07" @default.
- W2912459817 modified "2023-10-17" @default.
- W2912459817 title "Grammar of protein domain architectures" @default.
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- W2912459817 cites W1969460352 @default.
- W2912459817 cites W1972436629 @default.
- W2912459817 cites W1972628065 @default.
- W2912459817 cites W1973400336 @default.
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- W2912459817 cites W1987101747 @default.
- W2912459817 cites W1988714210 @default.
- W2912459817 cites W1992549770 @default.
- W2912459817 cites W1995875735 @default.
- W2912459817 cites W2000081657 @default.
- W2912459817 cites W2000690799 @default.
- W2912459817 cites W2005528634 @default.
- W2912459817 cites W2009505131 @default.
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- W2912459817 cites W2112792893 @default.
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- W2912459817 cites W2130581715 @default.
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- W2912459817 cites W2131232002 @default.
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- W2912459817 cites W2156372459 @default.
- W2912459817 cites W2161211166 @default.
- W2912459817 cites W2161303529 @default.
- W2912459817 cites W2161762698 @default.
- W2912459817 cites W2162170584 @default.
- W2912459817 cites W2171020662 @default.
- W2912459817 cites W2171477019 @default.
- W2912459817 cites W2192585006 @default.
- W2912459817 cites W2401701515 @default.
- W2912459817 cites W2518553291 @default.
- W2912459817 cites W2540384396 @default.
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- W2912459817 cites W4210623056 @default.
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- W2912459817 doi "https://doi.org/10.1073/pnas.1814684116" @default.
- W2912459817 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6397568" @default.
- W2912459817 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30733291" @default.
- W2912459817 hasPublicationYear "2019" @default.
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