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- W2912563005 endingPage "1063" @default.
- W2912563005 startingPage "1049" @default.
- W2912563005 abstract "Abstract General anesthetics have been used to ablate consciousness during surgery for more than 150 yr. Despite significant advances in our understanding of their molecular-level pharmacologic effects, comparatively little is known about how anesthetics alter brain dynamics to cause unconsciousness. Consequently, while anesthesia practice is now routine and safe, there are many vagaries that remain unexplained. In this paper, the authors review the evidence that cortical network activity is particularly sensitive to general anesthetics, and suggest that disruption to communication in, and/or among, cortical brain regions is a common mechanism of anesthesia that ultimately produces loss of consciousness. The authors review data from acute brain slices and organotypic cultures showing that anesthetics with differing molecular mechanisms of action share in common the ability to impair neurophysiologic communication. While many questions remain, together, ex vivo and in vivo investigations suggest that a unified understanding of both clinical anesthesia and the neural basis of consciousness is attainable." @default.
- W2912563005 created "2019-02-21" @default.
- W2912563005 creator A5008472209 @default.
- W2912563005 creator A5037469144 @default.
- W2912563005 creator A5043497497 @default.
- W2912563005 creator A5056424021 @default.
- W2912563005 date "2019-06-01" @default.
- W2912563005 modified "2023-10-05" @default.
- W2912563005 title "Understanding the Effects of General Anesthetics on Cortical Network Activity Using <i>Ex Vivo</i> Preparations" @default.
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