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- W2914677682 abstract "In this work six PBN-related indanonitrones 1–6 have been designed, synthesized, and their neuroprotection capacity tested in vitro, under OGD conditions, in SH-SY5Y human neuroblastoma cell cultures. As a result, we have identified indanonitrones 1, 3 and 4 (EC50 = 6.64 ± 0.28 μM) as the most neuroprotective agents, and in particular, among them, indanonitrone 4 was also the most potent and balanced nitrone, showing antioxidant activity in three experiments [LOX (100 μM), APPH (51%), DPPH (36.5%)], being clearly more potent antioxidant agent than nitrone PBN. Consequently, we have identified (Z)-5-hydroxy-N-methyl-2,3-dihydro-1H-inden-1-imine oxide (4) as a hit-molecule for further investigation." @default.
- W2914677682 created "2019-02-21" @default.
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- W2914677682 date "2019-05-01" @default.
- W2914677682 modified "2023-10-17" @default.
- W2914677682 title "Synthesis, neuroprotective and antioxidant capacity of PBN-related indanonitrones" @default.
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- W2914677682 doi "https://doi.org/10.1016/j.bioorg.2019.01.071" @default.
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