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• W2916615087 endingPage "349" @default.
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• W2916615087 abstract "Probiotics play an important role in maintaining a healthy and stable intestinal microbiota, primarily by preventing infection. Probiotic lactic acid bacteria (LAB) are known to be inhibitory to many bacterial enteric pathogens, including antibiotic-resistant strains. Whilst the positive role that probiotics have on human physiology, specifically in the treatment or prevention of specific infectious diseases of the gastro-intestinal tract (GIT) is known, the precise mechanistic basis of these effects remains a major research goal. In this study, molecular evidence to underpin the protective and anti-listerial effect of Lactobacillus plantarum 423 and Enterococcus mundtii ST4SA against orally administered Listeria monocytogenes EGDe in the GIT of mice is provided. Bacteriocins plantaricin 423 and mundticin ST4SA, produced by L. plantarum 423 and E. mundtii ST4SA, respectively, inhibited the growth of L. monocytogenes in vitro and in vivo. Bacteriocin-negative mutants of L. plantarum 423 and E. mundtii ST4SA failed to exclude L. monocytogenes EGDe from the gastrointestinal tract (GIT) of mice. Furthermore, L. plantarum 423 and E. mundtii ST4SA failed to inhibit recombinant strains of L. monocytogenes EGDe in vivo that expressed the immunity proteins of the two bacteriocins. These results confirmed that bacteriocins plantaricin 423 and mundticin ST4SA acted as anti-infective mediators in vivo. Compared to wild type strains, mutants of L. plantarum 423 and E. mundtii ST4SA, in which the adhesion genes were knocked out, were less effective in the exclusion of L. monocytogenes EGDe from the GIT of mice. This work demonstrates the importance of bacteriocin and adhesion genes as probiotic anti-infective mechanisms." @default.
• W2916615087 created "2019-03-02" @default.
• W2916615087 creator A5000349246 @default.
• W2916615087 creator A5026721681 @default.
• W2916615087 creator A5052217124 @default.
• W2916615087 date "2019-04-19" @default.
• W2916615087 modified "2023-09-26" @default.
• W2916615087 title "Bacteriocin production and adhesion properties as mechanisms for the anti-listerial activity of <i>Lactobacillus plantarum</i> 423 and <i>Enterococcus mundtii</i> ST4SA" @default.
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• W2916615087 doi "https://doi.org/10.3920/bm2018.0141" @default.
• W2916615087 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30773929" @default.
• W2916615087 hasPublicationYear "2019" @default.
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