FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2934884762> ?p ?o ?g. }

• W2934884762 endingPage "219" @default.
• W2934884762 startingPage "199" @default.
• W2934884762 abstract "Background:Gray matter (GM) atrophy in the striatum and across the brain is a consistently reported feature of the Huntington Disease (HD) prodrome. More recently, widespread prodromal white matter (WM) degradation has also been detected. However, longitudinal WM studies are limited and conflicting , and most analyses comparing WM and clinical functioning have also been cross-sectional. Objective:We simultaneously assessed changes in WM and cognitive and motor functioning at various prodromal HD stages. Methods:Data from 1,336 (1,047 prodromal, 289 control) PREDICT-HD participants were analyzed (3,700 sessions). MRI images were used to create GM, WM, and cerebrospinal fluid probability maps. Using source-based morphometry, independent component analysis was applied to WM probability maps to extract covarying spatial patterns and their subject profiles. WM profiles were analyzed in two sets of linear mixed model (LMM) analyses: one to compare WM profiles across groups cross-sectionally and longitudinally, and one to concurrently compare WM profiles and clinical variables cross-sectionally and longitudinally within each group. Results:Findings illustrate widespread prodromal changes in GM-adjacent-WM, with premotor, supplementary motor, middle frontal and striatal changes early in the prodrome that subsequently extend sub-gyrally with progression. Motor functioning agreed most with WM until the near-onset prodromal stage, when Stroop interference was the best WM indicator. Across groups, Trail-Making Test part A outperformed other cognitive variables in its similarity to WM, particularly cross-sectionally. Conclusions:Results suggest that distinct regions coincide with cognitive compared to motor functioning. Furthermore, at different prodromal stages, distinct regions appear to align best with clinical functioning. Thus, the informativeness of clinical measures may vary according to the type of data available (cross-sectional or longitudinal) as well as age and CAG-number." @default.
• W2934884762 created "2019-04-11" @default.
• W2934884762 creator A5005182829 @default.
• W2934884762 creator A5018879276 @default.
• W2934884762 creator A5023066870 @default.
• W2934884762 creator A5028903855 @default.
• W2934884762 creator A5030080051 @default.
• W2934884762 creator A5032850756 @default.
• W2934884762 creator A5048054839 @default.
• W2934884762 creator A5060135772 @default.
• W2934884762 creator A5066292657 @default.
• W2934884762 creator A5082230429 @default.
• W2934884762 creator A5084167572 @default.
• W2934884762 date "2019-04-30" @default.
• W2934884762 modified "2023-10-16" @default.
• W2934884762 title "Concurrent Cross-Sectional and Longitudinal Analyses of Multivariate White Matter Profiles and Clinical Functioning in Pre-Diagnosis Huntington Disease" @default.
• W2934884762 cites W1179800764 @default.
• W2934884762 cites W1490649113 @default.
• W2934884762 cites W1552525306 @default.
• W2934884762 cites W1565019306 @default.
• W2934884762 cites W1591042602 @default.
• W2934884762 cites W1904647953 @default.
• W2934884762 cites W1966491155 @default.
• W2934884762 cites W1978983000 @default.
• W2934884762 cites W1980553836 @default.
• W2934884762 cites W1982422745 @default.
• W2934884762 cites W1989339023 @default.
• W2934884762 cites W1994473527 @default.
• W2934884762 cites W1997669050 @default.
• W2934884762 cites W1998600758 @default.
• W2934884762 cites W2000555003 @default.
• W2934884762 cites W2004460775 @default.
• W2934884762 cites W2006952111 @default.
• W2934884762 cites W2009304595 @default.
• W2934884762 cites W2020488742 @default.
• W2934884762 cites W2021549489 @default.
• W2934884762 cites W2024954481 @default.
• W2934884762 cites W2026801435 @default.
• W2934884762 cites W2027575000 @default.
• W2934884762 cites W2029638099 @default.
• W2934884762 cites W2031417185 @default.
• W2934884762 cites W2032120877 @default.
• W2934884762 cites W2038253384 @default.
• W2934884762 cites W2038560960 @default.
• W2934884762 cites W2038908449 @default.
• W2934884762 cites W2040904602 @default.
• W2934884762 cites W2043416479 @default.
• W2934884762 cites W2065885725 @default.
• W2934884762 cites W2071579169 @default.
• W2934884762 cites W2082207932 @default.
• W2934884762 cites W2084451675 @default.
• W2934884762 cites W2084646748 @default.
• W2934884762 cites W2090664364 @default.
• W2934884762 cites W2095529469 @default.
• W2934884762 cites W2098935457 @default.
• W2934884762 cites W2099567248 @default.
• W2934884762 cites W2100724978 @default.
• W2934884762 cites W2101354696 @default.
• W2934884762 cites W2113441901 @default.
• W2934884762 cites W2113661629 @default.
• W2934884762 cites W2113872322 @default.
• W2934884762 cites W2119331647 @default.
• W2934884762 cites W2119720840 @default.
• W2934884762 cites W2120357670 @default.
• W2934884762 cites W2121642311 @default.
• W2934884762 cites W2124660038 @default.
• W2934884762 cites W2127936094 @default.
• W2934884762 cites W2129248479 @default.
• W2934884762 cites W2129250133 @default.
• W2934884762 cites W2136145485 @default.
• W2934884762 cites W2136468386 @default.
• W2934884762 cites W2166793287 @default.
• W2934884762 cites W2256392690 @default.
• W2934884762 cites W2288009109 @default.
• W2934884762 cites W2308725667 @default.
• W2934884762 cites W2333870512 @default.
• W2934884762 cites W2339309886 @default.
• W2934884762 cites W2487156940 @default.
• W2934884762 cites W2522532977 @default.
• W2934884762 cites W2563388089 @default.
• W2934884762 cites W2588265422 @default.
• W2934884762 cites W2604741857 @default.
• W2934884762 cites W2610225842 @default.
• W2934884762 cites W2727424619 @default.
• W2934884762 cites W2781552969 @default.
• W2934884762 cites W2790990710 @default.
• W2934884762 cites W2809003539 @default.
• W2934884762 cites W4230076583 @default.
• W2934884762 doi "https://doi.org/10.3233/jhd-180332" @default.
• W2934884762 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30932891" @default.
• W2934884762 hasPublicationYear "2019" @default.
• W2934884762 type Work @default.
• W2934884762 sameAs 2934884762 @default.
• W2934884762 citedByCount "1" @default.
• W2934884762 countsByYear W29348847622022 @default.
• W2934884762 crossrefType "journal-article" @default.
• W2934884762 hasAuthorship W2934884762A5005182829 @default.
• W2934884762 hasAuthorship W2934884762A5018879276 @default.

• next