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• W2937076225 abstract "Five-year survival for pancreatic ductal adenocarcinoma (PDAC) patients remains below 7% due to the lack of effective treatments. Here, we report that combined ablation of EGFR and c-RAF expression results in complete regression of a significant percentage of PDAC tumors driven by Kras/Trp53 mutations in genetically engineered mice. Moreover, systemic elimination of these targets induces toxicities that are well tolerated. Response to this targeted therapy correlates with transcriptional profiles that resemble those observed in human PDACs. Finally, inhibition of EGFR and c-RAF expression effectively blocked tumor progression in nine independent patient-derived xenografts carrying KRAS and TP53 mutations. These results open the door to the development of targeted therapies for PDAC patients." @default.
• W2937076225 created "2019-04-25" @default.
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• W2937076225 date "2019-04-01" @default.
• W2937076225 modified "2023-10-16" @default.
• W2937076225 title "Complete Regression of Advanced Pancreatic Ductal Adenocarcinomas upon Combined Inhibition of EGFR and C-RAF" @default.
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• W2937076225 cites W2128059000 @default.
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• W2937076225 cites W2159707944 @default.
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• W2937076225 cites W2164942973 @default.
• W2937076225 cites W2165480504 @default.
• W2937076225 cites W2179438025 @default.
• W2937076225 cites W2214074259 @default.
• W2937076225 cites W2285093314 @default.
• W2937076225 cites W2307223176 @default.
• W2937076225 cites W2495582206 @default.
• W2937076225 cites W2531470489 @default.
• W2937076225 cites W2586629973 @default.
• W2937076225 cites W2624616322 @default.
• W2937076225 cites W2740325081 @default.
• W2937076225 cites W2742294110 @default.
• W2937076225 cites W2748710555 @default.
• W2937076225 cites W2751545854 @default.
• W2937076225 cites W2769127580 @default.
• W2937076225 cites W2769455020 @default.
• W2937076225 cites W2772812510 @default.
• W2937076225 cites W2785043177 @default.
• W2937076225 cites W2787649310 @default.
• W2937076225 cites W2793975714 @default.
• W2937076225 cites W2807088563 @default.
• W2937076225 cites W2808191072 @default.
• W2937076225 cites W4211122150 @default.
• W2937076225 cites W4244578979 @default.
• W2937076225 cites W4247053599 @default.
• W2937076225 cites W43670395 @default.

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