FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2937438478> ?p ?o ?g. }

• W2937438478 abstract "Hepatocellular carcinoma (HCC) is now the second-highest cause of cancer death worldwide. Recent studies have discovered a wide range of somatic mutations in HCC. These mutations involve various vital signaling pathways such as: Wnt/β-Catenin, p53, telome-rase reverse transcriptase (TERT), chromatin remodeling, RAS/MAPK signaling, and oxidative stress. However, fusion transcripts have not been broadly explored in HCC.To identify novel fusion transcripts in HCC, in the first phase of our study, we performed targeted RNA sequencing (in HCC and paired non-HCC tissues) on 6 patients with a diagnosis of HCC undergoing liver transplantation.As a result of these studies, we discovered the novel fusion transcript, VTI1A-CFAP46. In the second phase of our study, we measured the expression of wild-type VTI1A in 21 HCC specimens, which showed that 10 of 21 exhibited upregulation of wild-type VTI1A in their tumors. VTI1A (Vesicle Transport via Interaction with t-SNARE homolog 1A) is a member of the Soluble N-ethylmaleimide-Sensitive Factor (NSF) attachment protein receptor (SNARE) gene family, which is essential for membrane trafficking and function in endocytosis, autophagy, and Golgi transport. Notably, it is known that autophagy is involved in HCC.The link between novel fusion transcript VTI1A-CFAP46 and autophagy as a potential therapeutic target in HCC patients deserves further investigation. Moreover, this study shows that fusion transcripts are worthy of additional exploration in HCC." @default.
• W2937438478 created "2019-04-25" @default.
• W2937438478 creator A5008314164 @default.
• W2937438478 creator A5011476548 @default.
• W2937438478 creator A5014834423 @default.
• W2937438478 creator A5019685966 @default.
• W2937438478 creator A5024270187 @default.
• W2937438478 creator A5025711714 @default.
• W2937438478 creator A5026257344 @default.
• W2937438478 creator A5029421561 @default.
• W2937438478 creator A5029759065 @default.
• W2937438478 creator A5032028356 @default.
• W2937438478 creator A5033696694 @default.
• W2937438478 creator A5038289070 @default.
• W2937438478 creator A5044349722 @default.
• W2937438478 creator A5050832231 @default.
• W2937438478 creator A5052352078 @default.
• W2937438478 creator A5078918804 @default.
• W2937438478 creator A5082111369 @default.
• W2937438478 creator A5083832323 @default.
• W2937438478 date "2019-01-01" @default.
• W2937438478 modified "2023-10-18" @default.
• W2937438478 title "Detection of Novel Fusion Transcript VTI1A-CFAP46 in Hepatocellular Carcinoma" @default.
• W2937438478 cites W1525145973 @default.
• W2937438478 cites W1559511540 @default.
• W2937438478 cites W1790423369 @default.
• W2937438478 cites W1810761522 @default.
• W2937438478 cites W1863396492 @default.
• W2937438478 cites W1946257664 @default.
• W2937438478 cites W1970060716 @default.
• W2937438478 cites W1974489853 @default.
• W2937438478 cites W1980719375 @default.
• W2937438478 cites W2011957420 @default.
• W2937438478 cites W2015361583 @default.
• W2937438478 cites W2018080595 @default.
• W2937438478 cites W2018851752 @default.
• W2937438478 cites W2023815439 @default.
• W2937438478 cites W2028319026 @default.
• W2937438478 cites W2034820020 @default.
• W2937438478 cites W2038440796 @default.
• W2937438478 cites W2055402151 @default.
• W2937438478 cites W2058797935 @default.
• W2937438478 cites W2061743943 @default.
• W2937438478 cites W2065425090 @default.
• W2937438478 cites W2068149517 @default.
• W2937438478 cites W2071168599 @default.
• W2937438478 cites W2073689740 @default.
• W2937438478 cites W2079298594 @default.
• W2937438478 cites W2082880246 @default.
• W2937438478 cites W2084787346 @default.
• W2937438478 cites W2088301231 @default.
• W2937438478 cites W2090339804 @default.
• W2937438478 cites W2096460033 @default.
• W2937438478 cites W2097065948 @default.
• W2937438478 cites W2102690338 @default.
• W2937438478 cites W2112044462 @default.
• W2937438478 cites W2114843025 @default.
• W2937438478 cites W2116836791 @default.
• W2937438478 cites W2124985265 @default.
• W2937438478 cites W2126715104 @default.
• W2937438478 cites W2135640980 @default.
• W2937438478 cites W2149441684 @default.
• W2937438478 cites W2158378236 @default.
• W2937438478 cites W2164173382 @default.
• W2937438478 cites W2164241627 @default.
• W2937438478 cites W2165664339 @default.
• W2937438478 cites W2169456326 @default.
• W2937438478 cites W2235737683 @default.
• W2937438478 cites W2346531348 @default.
• W2937438478 cites W2398047035 @default.
• W2937438478 cites W2594488303 @default.
• W2937438478 cites W263822530 @default.
• W2937438478 cites W326741768 @default.
• W2937438478 doi "https://doi.org/10.1159/000496795" @default.
• W2937438478 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6738276" @default.
• W2937438478 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31602373" @default.
• W2937438478 hasPublicationYear "2019" @default.
• W2937438478 type Work @default.
• W2937438478 sameAs 2937438478 @default.
• W2937438478 citedByCount "2" @default.
• W2937438478 countsByYear W29374384782020 @default.
• W2937438478 countsByYear W29374384782022 @default.
• W2937438478 crossrefType "journal-article" @default.
• W2937438478 hasAuthorship W2937438478A5008314164 @default.
• W2937438478 hasAuthorship W2937438478A5011476548 @default.
• W2937438478 hasAuthorship W2937438478A5014834423 @default.
• W2937438478 hasAuthorship W2937438478A5019685966 @default.
• W2937438478 hasAuthorship W2937438478A5024270187 @default.
• W2937438478 hasAuthorship W2937438478A5025711714 @default.
• W2937438478 hasAuthorship W2937438478A5026257344 @default.
• W2937438478 hasAuthorship W2937438478A5029421561 @default.
• W2937438478 hasAuthorship W2937438478A5029759065 @default.
• W2937438478 hasAuthorship W2937438478A5032028356 @default.
• W2937438478 hasAuthorship W2937438478A5033696694 @default.
• W2937438478 hasAuthorship W2937438478A5038289070 @default.
• W2937438478 hasAuthorship W2937438478A5044349722 @default.
• W2937438478 hasAuthorship W2937438478A5050832231 @default.
• W2937438478 hasAuthorship W2937438478A5052352078 @default.
• W2937438478 hasAuthorship W2937438478A5078918804 @default.
• W2937438478 hasAuthorship W2937438478A5082111369 @default.

• next