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• W2942170805 startingPage "216" @default.
• W2942170805 abstract "Analogs of benzothiazole orange (BO) with one, two or three methylbenzothiazolylmethylidene substituents in the 1-methylpyridinium ring were obtained from the respective picolinium, lutidinium or collidinium salts. Fluorescence parameters of the known and new dyes in complexes with various DNA structures, including G-quadruplexes (G4s) and i-motifs (IMs), were analyzed. All dyes efficiently distinguished G4s and ss-DNA. The bi- and tri-substituted derivatives had basically similar distributions of relative fluorescence intensities. The mono-substituted derivatives exhibited enhanced sensitivity to parallel G4s. All dyes were particularly sensitive to a G4 structure with an additional duplex module (the thrombin-binding aptamer TBA31), presumably due to a distinctive binding mode (interaction with the junction between the two modules). In particular, BO showed a strong (160-fold) enhancement in fluorescence quantum yield in complex with TBA31 compared to the free dye. The fluorescence quantum yields of the 2,4-bisubstituted derivative in complex with well-characterized G4s from oncogene promoters were in the range of 0.04–0.28, i.e. comparable to those of ThT. The mono/bi-substituted derivatives should be considered as possible light-up probes for G4 formation." @default.
• W2942170805 created "2019-05-03" @default.
• W2942170805 creator A5006077172 @default.
• W2942170805 creator A5014809547 @default.
• W2942170805 creator A5024185483 @default.
• W2942170805 creator A5054140141 @default.
• W2942170805 creator A5055888137 @default.
• W2942170805 creator A5059337263 @default.
• W2942170805 creator A5071336235 @default.
• W2942170805 date "2019-07-01" @default.
• W2942170805 modified "2023-10-01" @default.
• W2942170805 title "Benzothiazole-based cyanines as fluorescent “light-up” probes for duplex and quadruplex DNA" @default.
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