Matches in SemOpenAlex for { <https://semopenalex.org/work/W2945803920> ?p ?o ?g. }
- W2945803920 endingPage "1724" @default.
- W2945803920 startingPage "1716" @default.
- W2945803920 abstract "Abstract Systemic inflammation is associated with increasing age. Yet, there are limited data about the association between age and systemic inflammation within older adults, and whether older age is also associated with cellular and nuclear signaling markers of inflammation. In community-dwelling older adults (N = 262, 60–88 years), systemic levels of C-reactive protein, interleukin-6, and soluble tumor necrosis factor receptor II; levels of toll-like receptor-4–stimulated monocytic production of interleukin-6 and tumor necrosis factor α; and resting nuclear levels of activated nuclear factor kappa B and signal transducer and activator of transcription (STAT1, STAT3, STAT5) were evaluated. Adjusting for demographic and clinical factors, multivariate linear regression tested the association between age and each inflammatory marker. Age was positively associated with increased levels of interleukin-6 and soluble tumor necrosis factor receptor II (p’s < .05) and with increases in STAT1, STAT3, and STAT5 activation (p’s < .05). However, no relationship was found between age and C-reactive protein, toll-like receptor-4–stimulated interleukin-6/tumor necrosis factor alpha α production, or nuclear factor kappa B. Within a community-dwelling sample of older adults, older age is associated with increases in STAT activation, along with increases of systemic inflammatory cytokines. In older adults, heterogeneity in age-related increases in inflammatory disease risk may be related to individual variability in inflammation." @default.
- W2945803920 created "2019-05-29" @default.
- W2945803920 creator A5004871151 @default.
- W2945803920 creator A5005936736 @default.
- W2945803920 creator A5010333004 @default.
- W2945803920 creator A5011136538 @default.
- W2945803920 creator A5031182685 @default.
- W2945803920 creator A5043625675 @default.
- W2945803920 creator A5057942712 @default.
- W2945803920 creator A5059608732 @default.
- W2945803920 creator A5070840018 @default.
- W2945803920 creator A5091406579 @default.
- W2945803920 date "2019-05-20" @default.
- W2945803920 modified "2023-10-16" @default.
- W2945803920 title "Inflammaging: Age and Systemic, Cellular, and Nuclear Inflammatory Biology in Older Adults" @default.
- W2945803920 cites W1134731694 @default.
- W2945803920 cites W1563577784 @default.
- W2945803920 cites W158003248 @default.
- W2945803920 cites W1599031322 @default.
- W2945803920 cites W1963990081 @default.
- W2945803920 cites W1966789086 @default.
- W2945803920 cites W1970249195 @default.
- W2945803920 cites W1971750634 @default.
- W2945803920 cites W1976810663 @default.
- W2945803920 cites W1981477005 @default.
- W2945803920 cites W1989780776 @default.
- W2945803920 cites W2001720505 @default.
- W2945803920 cites W2002776738 @default.
- W2945803920 cites W2004068229 @default.
- W2945803920 cites W2010136315 @default.
- W2945803920 cites W2015101234 @default.
- W2945803920 cites W2030493262 @default.
- W2945803920 cites W2042353763 @default.
- W2945803920 cites W2042636372 @default.
- W2945803920 cites W2048105346 @default.
- W2945803920 cites W2052233887 @default.
- W2945803920 cites W2053623710 @default.
- W2945803920 cites W2054893928 @default.
- W2945803920 cites W2058544138 @default.
- W2945803920 cites W2062286859 @default.
- W2945803920 cites W2069798327 @default.
- W2945803920 cites W2071174103 @default.
- W2945803920 cites W2078730804 @default.
- W2945803920 cites W2079357798 @default.
- W2945803920 cites W2082402714 @default.
- W2945803920 cites W2087852931 @default.
- W2945803920 cites W2098432330 @default.
- W2945803920 cites W2101821254 @default.
- W2945803920 cites W2103807332 @default.
- W2945803920 cites W2108700752 @default.
- W2945803920 cites W2114449856 @default.
- W2945803920 cites W2116558079 @default.
- W2945803920 cites W2118424059 @default.
- W2945803920 cites W2118451050 @default.
- W2945803920 cites W2118767323 @default.
- W2945803920 cites W2123105952 @default.
- W2945803920 cites W2129155846 @default.
- W2945803920 cites W2130766522 @default.
- W2945803920 cites W2131056323 @default.
- W2945803920 cites W2132173287 @default.
- W2945803920 cites W2140500533 @default.
- W2945803920 cites W2142179136 @default.
- W2945803920 cites W2148230248 @default.
- W2945803920 cites W2150748567 @default.
- W2945803920 cites W2158033629 @default.
- W2945803920 cites W2159914115 @default.
- W2945803920 cites W2167409896 @default.
- W2945803920 cites W2173367702 @default.
- W2945803920 cites W2215361131 @default.
- W2945803920 cites W2259579158 @default.
- W2945803920 cites W2316821288 @default.
- W2945803920 cites W2738513284 @default.
- W2945803920 cites W2777892103 @default.
- W2945803920 cites W2803474895 @default.
- W2945803920 cites W2894635092 @default.
- W2945803920 cites W91255988 @default.
- W2945803920 doi "https://doi.org/10.1093/gerona/glz130" @default.
- W2945803920 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6777092" @default.
- W2945803920 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31107949" @default.
- W2945803920 hasPublicationYear "2019" @default.
- W2945803920 type Work @default.
- W2945803920 sameAs 2945803920 @default.
- W2945803920 citedByCount "38" @default.
- W2945803920 countsByYear W29458039202019 @default.
- W2945803920 countsByYear W29458039202020 @default.
- W2945803920 countsByYear W29458039202021 @default.
- W2945803920 countsByYear W29458039202022 @default.
- W2945803920 countsByYear W29458039202023 @default.
- W2945803920 crossrefType "journal-article" @default.
- W2945803920 hasAuthorship W2945803920A5004871151 @default.
- W2945803920 hasAuthorship W2945803920A5005936736 @default.
- W2945803920 hasAuthorship W2945803920A5010333004 @default.
- W2945803920 hasAuthorship W2945803920A5011136538 @default.
- W2945803920 hasAuthorship W2945803920A5031182685 @default.
- W2945803920 hasAuthorship W2945803920A5043625675 @default.
- W2945803920 hasAuthorship W2945803920A5057942712 @default.
- W2945803920 hasAuthorship W2945803920A5059608732 @default.
- W2945803920 hasAuthorship W2945803920A5070840018 @default.