FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2950702986> ?p ?o ?g. }

• W2950702986 endingPage "85" @default.
• W2950702986 startingPage "85" @default.
• W2950702986 abstract "Dengue infections are still a worldwide burden, especially in Indonesia. There is no specific medication against the dengue virus. Recently, many types of research have been conducted to discover a new drug for dengue virus using natural resource extracts. Indonesia, as a tropical country, has a wide biodiversity. There are several medicinal plants in Indonesia that are believed to possess anti-dengue activity, such as Myristica fatua, Cymbopogon citratus, and Acorus calamus plants. We conducted an in vitro laboratory experiment of several extracts from Indonesian herbs combined with in silico analysis. The extracts were evaluated for safety and antiviral activity in Huh7it-1 cell lines, using a single dose of 20 µg/mL and dose-dependent (5, 10, 20, 40, 80 and 160 µg/mL) of plant extracts against dengue virus serotype 2 (DENV-2) NGC strain. The DMSO 0.1% was used as a negative control. The cytotoxic aspect was assessed by counting the cell viability, while the antiviral activity was calculated by counting the average inhibition. The selectivity index (SI) of plant extracts were performed from a ratio of CC50/EC50 value. In silico analysis was conducted to determine the free energy of binding between NS5 of dengue virus with bioactive compounds contained in Myristica fatua, Cymbopogon citratus and Acorus calamus extract plants. We determined that all extracts were not toxic against Huh7it-1 cell lines. The methanolic extracts of A. calamus, C. citratus, and M. fatua showed inhibition of DENV-2 at a dose of 20 µg/mL to 96.5%, 98.9%, and 122.7%, respectively. The dose-dependent effects showed that M. fatua has the best inhibition activity towards DENV-2. Molecular docking result showed that artesunic acid within M. fatua has the best free energy of binding (−7.2 kcal/mol), followed by homoegonol (−7.1 kcal/mol) which was slightly different from artesunic acid among others. The methanolic extracts of A. calamus, C. citratus, and M. fatua showed prospective anti-dengue activities both in vitro and in silico. Future research should be conducted to find the pure extracts of all useful herbs as a new candidate of antiviral drug." @default.
• W2950702986 created "2019-06-27" @default.
• W2950702986 creator A5001284196 @default.
• W2950702986 creator A5006141468 @default.
• W2950702986 creator A5018331739 @default.
• W2950702986 creator A5020536775 @default.
• W2950702986 creator A5026369599 @default.
• W2950702986 creator A5040437962 @default.
• W2950702986 creator A5042754603 @default.
• W2950702986 creator A5051944458 @default.
• W2950702986 creator A5070576335 @default.
• W2950702986 creator A5074934189 @default.
• W2950702986 date "2019-06-22" @default.
• W2950702986 modified "2023-10-16" @default.
• W2950702986 title "The Antiviral Effect of Indonesian Medicinal Plant Extracts Against Dengue Virus In Vitro and In Silico" @default.
• W2950702986 cites W1899472707 @default.
• W2950702986 cites W1978410163 @default.
• W2950702986 cites W1978569086 @default.
• W2950702986 cites W1986813986 @default.
• W2950702986 cites W2033143477 @default.
• W2950702986 cites W2053490656 @default.
• W2950702986 cites W2056863055 @default.
• W2950702986 cites W2109111344 @default.
• W2950702986 cites W2116358014 @default.
• W2950702986 cites W2131222241 @default.
• W2950702986 cites W2134967712 @default.
• W2950702986 cites W2146594405 @default.
• W2950702986 cites W2149277978 @default.
• W2950702986 cites W2152185680 @default.
• W2950702986 cites W2163446105 @default.
• W2950702986 cites W2213162456 @default.
• W2950702986 cites W2263300094 @default.
• W2950702986 cites W2516001222 @default.
• W2950702986 cites W2565383127 @default.
• W2950702986 cites W2606434274 @default.
• W2950702986 cites W2617742067 @default.
• W2950702986 cites W2625454110 @default.
• W2950702986 cites W2734465900 @default.
• W2950702986 cites W2737571260 @default.
• W2950702986 cites W2748557953 @default.
• W2950702986 cites W2782778341 @default.
• W2950702986 cites W2801821897 @default.
• W2950702986 cites W2897594620 @default.
• W2950702986 doi "https://doi.org/10.3390/pathogens8020085" @default.
• W2950702986 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6631455" @default.
• W2950702986 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31234495" @default.
• W2950702986 hasPublicationYear "2019" @default.
• W2950702986 type Work @default.
• W2950702986 sameAs 2950702986 @default.
• W2950702986 citedByCount "43" @default.
• W2950702986 countsByYear W29507029862020 @default.
• W2950702986 countsByYear W29507029862021 @default.
• W2950702986 countsByYear W29507029862022 @default.
• W2950702986 countsByYear W29507029862023 @default.
• W2950702986 crossrefType "journal-article" @default.
• W2950702986 hasAuthorship W2950702986A5001284196 @default.
• W2950702986 hasAuthorship W2950702986A5006141468 @default.
• W2950702986 hasAuthorship W2950702986A5018331739 @default.
• W2950702986 hasAuthorship W2950702986A5020536775 @default.
• W2950702986 hasAuthorship W2950702986A5026369599 @default.
• W2950702986 hasAuthorship W2950702986A5040437962 @default.
• W2950702986 hasAuthorship W2950702986A5042754603 @default.
• W2950702986 hasAuthorship W2950702986A5051944458 @default.
• W2950702986 hasAuthorship W2950702986A5070576335 @default.
• W2950702986 hasAuthorship W2950702986A5074934189 @default.
• W2950702986 hasBestOaLocation W29507029861 @default.
• W2950702986 hasConcept C134550120 @default.
• W2950702986 hasConcept C159047783 @default.
• W2950702986 hasConcept C195475562 @default.
• W2950702986 hasConcept C2775935906 @default.
• W2950702986 hasConcept C2776100074 @default.
• W2950702986 hasConcept C2777278459 @default.
• W2950702986 hasConcept C2779158651 @default.
• W2950702986 hasConcept C2779627925 @default.
• W2950702986 hasConcept C2779635636 @default.
• W2950702986 hasConcept C533803919 @default.
• W2950702986 hasConcept C556039675 @default.
• W2950702986 hasConcept C59822182 @default.
• W2950702986 hasConcept C71924100 @default.
• W2950702986 hasConcept C86803240 @default.
• W2950702986 hasConceptScore W2950702986C134550120 @default.
• W2950702986 hasConceptScore W2950702986C159047783 @default.
• W2950702986 hasConceptScore W2950702986C195475562 @default.
• W2950702986 hasConceptScore W2950702986C2775935906 @default.
• W2950702986 hasConceptScore W2950702986C2776100074 @default.
• W2950702986 hasConceptScore W2950702986C2777278459 @default.
• W2950702986 hasConceptScore W2950702986C2779158651 @default.
• W2950702986 hasConceptScore W2950702986C2779627925 @default.
• W2950702986 hasConceptScore W2950702986C2779635636 @default.
• W2950702986 hasConceptScore W2950702986C533803919 @default.
• W2950702986 hasConceptScore W2950702986C556039675 @default.
• W2950702986 hasConceptScore W2950702986C59822182 @default.
• W2950702986 hasConceptScore W2950702986C71924100 @default.
• W2950702986 hasConceptScore W2950702986C86803240 @default.
• W2950702986 hasIssue "2" @default.
• W2950702986 hasLocation W29507029861 @default.
• W2950702986 hasLocation W29507029862 @default.
• W2950702986 hasLocation W29507029863 @default.

• next